Invention Grant
- Patent Title: Substituted indole compounds useful as TLR inhibitors
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Application No.: US16955097Application Date: 2018-12-18
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Publication No.: US11878975B2Publication Date: 2024-01-23
- Inventor: Alaric J. Dyckman , Dharmpal S. Dodd , Christopher P. Mussari , John L. Gilmore , Tasir Shamsul Haque , Trevor C. Sherwood , Brian K. Whiteley , Shoshana L. Posy , Sreekantha Ratna Kumar , Laxman Pasunoori , Srinivasan Kunchithapatham Duraisamy , Subramanya Hegde , Rushith Kumar Anumula , Pitani Veera Venkata Srinivas
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary Greenblatt
- International Application: PCT/US2018/066149 2018.12.18
- International Announcement: WO2019/126113A 2019.06.27
- Date entered country: 2020-06-18
- Main IPC: C07D471/08
- IPC: C07D471/08 ; C07D487/08 ; C07D519/00 ; C07D471/04 ; C07D401/04 ; C07D401/10 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D417/14 ; C07D453/02 ; C07D487/04 ; C07D491/08

Abstract:
Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
Public/Granted literature
- US20200308172A1 SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR INHIBITORS Public/Granted day:2020-10-01
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