公开(公告)号：US11878975B2

公开(公告)日：2024-01-23

申请号：US16955097

申请日：2018-12-18

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  John L. Gilmore ,  Tasir Shamsul Haque ,  Trevor C. Sherwood ,  Brian K. Whiteley ,  Shoshana L. Posy ,  Sreekantha Ratna Kumar ,  Laxman Pasunoori ,  Srinivasan Kunchithapatham Duraisamy ,  Subramanya Hegde ,  Rushith Kumar Anumula ,  Pitani Veera Venkata Srinivas

IPC分类号： C07D471/08 ,  C07D487/08 ,  C07D519/00 ,  C07D471/04 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/02 ,  C07D487/04 ,  C07D491/08

CPC分类号： C07D471/04 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/02 ,  C07D487/04 ,  C07D491/08

摘要： Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US11447466B2

公开(公告)日：2022-09-20

申请号：US16635593

申请日：2018-08-03

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Tasir Shamsul Haque ,  Brian K. Whiteley ,  John L. Gilmore

IPC分类号： A61K31/4545 ,  A61P29/00 ,  A61P37/00 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

摘要： Disclosed are compounds of Formula (I) or a salt thereof, wherein: Y is Formula (II), or Formula (III); R1, R2, R2a, R2b, R2c, R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US20200038374A1

公开(公告)日：2020-02-06

申请号：US16653297

申请日：2019-10-15

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Tasir Shamsul Haque ,  Louis J. Lombardo ,  John E. Macor ,  Christopher P. Mussari ,  Laxman Pasunoori ,  Sreekantha Ratna Kumar ,  Trevor C. Sherwood ,  Shoshana L. Posy ,  Ramesh Kumar Sistla ,  Subramanya Hegde ,  Anupama Kandhi Ramachandra Reddy

IPC分类号： A61K31/4196 ,  C07D249/00 ,  A61K31/437 ,  A61K31/4427 ,  A61K45/06 ,  C07D471/04

摘要： Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US11672780B2

公开(公告)日：2023-06-13

申请号：US17113495

申请日：2020-12-07

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Tasir Shamsul Haque ,  Louis J. Lombardo ,  John E. Macor ,  Christopher P. Mussari ,  Laxman Pasunoori ,  Sreekantha Ratna Kumar ,  Trevor C. Sherwood ,  Shoshana L. Posy ,  Ramesh Kumar Sistla ,  Subramanya Hegde ,  Anupama Kandhi Ramachandra Reddy

IPC分类号： A61K31/4196 ,  A61K31/437 ,  A61K31/4427 ,  A61K45/06 ,  C07D471/04 ,  C07D249/00

CPC分类号： A61K31/4196 ,  A61K31/437 ,  A61K31/4427 ,  A61K45/06 ,  C07D249/00 ,  C07D471/04

摘要： Disclosed are compounds of Formula (I)




or a salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US10660877B2

公开(公告)日：2020-05-26

申请号：US16330964

申请日：2017-09-08

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Tasir Shamsul Haque ,  Louis J. Lombardo ,  John E. Macor ,  Christopher P. Mussari ,  Laxman Pasunoori ,  Michael A. Poss ,  Sreekantha Ratna Kumar ,  Shoshana L. Posy ,  David R. Tortolani ,  Brian K. Whiteley ,  Ramesh Kumar Sistla ,  Subramanya Hegde ,  Anupama Kandhi Ramachandra Reddy

IPC分类号： A61K31/404 ,  A61P37/06 ,  A61P29/00 ,  A61K9/00 ,  C07D401/14

摘要： Disclosed are compounds of Formula (I) N-oxide, or salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US20210253593A1

公开(公告)日：2021-08-19

申请号：US16763670

申请日：2018-11-13

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  Trevor C. Sherwood ,  John L. Gilmore ,  Tasir Shamsul Haque ,  Brian K. Whiteley ,  David R. Tortolani ,  Shoshana L. Posy ,  John E. Macor ,  Louis J. Lombardo ,  Ramesh Kumar Sistla ,  Anupama Kandhi Ramachandra Reddy ,  Subramanya Hegde ,  Laxman Pasunoori ,  Sreekantha Ratna Kumar

IPC分类号： C07D498/04 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D417/14 ,  C07D405/14 ,  C07D513/04 ,  C07D401/14 ,  C07D495/04

摘要： Disclosed are compounds of Formula (I) or salts thereof, wherein Ring Het, R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US20210085651A1

公开(公告)日：2021-03-25

申请号：US17113495

申请日：2020-12-07

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Tasir Shamsul Haque ,  Louis J. Lombardo ,  John E. Macor ,  Christopher P. Mussari ,  Laxman Pasunoori ,  Sreekantha Ratna Kumar ,  Trevor C. Sherwood ,  Shoshana L. Posy ,  Ramesh Kumar Sistla ,  Subramanya Hegde ,  Anupama Kandhi Ramachandra Reddy

IPC分类号： A61K31/4196 ,  C07D249/00 ,  A61K31/437 ,  A61K31/4427 ,  A61K45/06 ,  C07D471/04

摘要： Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US20200339581A1

公开(公告)日：2020-10-29

申请号：US16955166

申请日：2018-12-19

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  David R. Tortolani ,  Tasir Shamsul Haque ,  Shoshana L. Posy

IPC分类号： C07D471/10 ,  C07D401/14 ,  C07D403/04 ,  C07D471/04 ,  C07D209/12 ,  C07D413/12 ,  C07D409/14

摘要： Disclosed are compounds of Formula (I) or salts thereof, wherein G, R1, R5, R7, R8, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US20200331920A1

公开(公告)日：2020-10-22

申请号：US16954543

申请日：2018-12-18

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  Trevor C. Sherwood ,  Tasir Shamsul Haque ,  Shoshana L. Posy ,  Sreekantha Ratna Kumar ,  Laxman Pasunoori ,  Subramanya Hegde ,  Rushith Kumar Anumula

IPC分类号： C07D487/04 ,  C07D403/10 ,  C07D491/08 ,  C07D209/42 ,  C07D405/14 ,  C07D401/12 ,  C07D417/14 ,  C07D401/14 ,  C07D401/10 ,  C07D417/12 ,  C07D403/14

摘要： N-oxides, or salts thereof, wherein G, L2, R1, R5, R9, R10, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmunediseases.

公开(公告)号：US20200239437A1

公开(公告)日：2020-07-30

申请号：US16635593

申请日：2018-08-03

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Tasir Shamsul Haque ,  Brian K. Whiteley ,  John L. Gilmore

IPC分类号： C07D401/14 ,  C07D405/14 ,  C07D409/14

摘要： Disclosed are compounds of Formula (I) or a salt thereof, wherein: Y is Formula (II), or Formula (III); R1, R2, R2a, R2b, R2c, R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.