公开(公告)号：US20180362508A1

公开(公告)日：2018-12-20

申请号：US16061365

申请日：2016-12-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Michael C. Myers ,  R. Michael Lawrence ,  Donna M. Bilder ,  Wei Meng ,  Zulan Pi ,  Robert Paul Brigance ,  Heather Finlay

IPC: C07D403/04 ,  C07D413/14 ,  C07D413/04 ,  C07D417/14

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments, in particular for treating cardiovascular disorders.

公开(公告)号：US20240417369A1

公开(公告)日：2024-12-19

申请号：US18700868

申请日：2022-10-28

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Donald J. P. Pinto ,  Shun Su ,  Arvind Mathur ,  Michael C. Myers ,  Jianqing Li ,  Kumar Balashanmuga Pabbisetty ,  Scott A. Shaw

IPC: C07C235/14 ,  A61K31/167 ,  A61K31/17 ,  A61K31/192 ,  A61K31/424 ,  C07C235/74 ,  C07C235/84 ,  C07C275/34 ,  C07D498/04

Abstract: The disclosure relates to compounds of Formula (I), which are RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such as lung disease (e.g., idiopathic pulmonary fibrosis), kidney disease (e.g., chronic kidney disease), or hepatic disease (e.g., non-alcoholic steatohepatitis and portal hypertension).

公开(公告)号：US10590113B2

公开(公告)日：2020-03-17

申请号：US16122975

申请日：2018-09-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Zulan Pi ,  Donna M. Bilder ,  Robert Paul Brigance ,  Heather Finlay ,  Wen Jiang ,  James A. Johnson ,  R. Michael Lawrence ,  Wei Meng ,  Michael C. Myers ,  Monique Phillips ,  George O. Tora ,  Xiaojun Zhang

IPC: A61K31/505 ,  C07D403/06 ,  C07D401/06 ,  C07D403/14 ,  C07D239/557 ,  C07D239/54 ,  C07D239/545 ,  C07D401/14 ,  C07D403/02 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

公开(公告)号：US20190256570A1

公开(公告)日：2019-08-22

申请号：US16287342

申请日：2019-02-27

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Gene M. Dubowchik ,  Olafur S. Gudmundsson ,  Xiaojun Han ,  R. Michael Lawrence ,  Dasa Lipovsek ,  Cort S. Madsen ,  Claudio Mapelli ,  Paul E. Morin ,  Michael C. Myers

IPC: C07K14/64 ,  C07K1/107

Abstract: The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.

公开(公告)号：US20180222960A1

公开(公告)日：2018-08-09

申请号：US15891492

申请日：2018-02-08

Applicant: Bristol-Myers Squibb Company

Inventor： Gene M. DUBOWCHIK ,  Olafur S. Gudmundsson ,  Xiaojun Han ,  R. Michael Lawrence ,  Dasa Lipovsek ,  Cort S. Madsen ,  Claudio Mapelli ,  Paul E. Morin ,  Michael C. Myers

IPC: C07K14/64 ,  C07K1/107 ,  A61P9/00 ,  A61K47/64

CPC classification number: C07K14/64 ,  A61K38/00 ,  A61K45/06 ,  A61K47/64 ,  A61P9/00 ,  C07K1/1077

Abstract: The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.

公开(公告)号：US12168655B2

公开(公告)日：2024-12-17

申请号：US17836596

申请日：2022-06-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Wei Meng ,  Hannguang J. Chao ,  Heather Finlay ,  R. Michael Lawrence ,  Michael C. Myers

IPC: C07D413/10 ,  C07D239/54 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

公开(公告)号：US12097242B2

公开(公告)日：2024-09-24

申请号：US17721569

申请日：2022-04-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Gene M. Dubowchik ,  Olafur S. Gudmundsson ,  Xiaojun Han ,  R. Michael Lawrence ,  Dasa Lipovsek ,  Cort S. Madsen ,  Claudio Mapelli ,  Paul E. Morin ,  Michael C. Myers

IPC: A61K38/22 ,  A61K38/18 ,  C07K1/107 ,  C07K14/64 ,  A61K38/00 ,  A61K45/06 ,  A61K47/64 ,  A61P9/00

CPC classification number: A61K38/18 ,  A61K38/2221 ,  C07K1/1077 ,  C07K14/64 ,  A61K38/00 ,  A61K45/06 ,  A61K47/64 ,  A61P9/00

Abstract: The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.

公开(公告)号：US11364281B2

公开(公告)日：2022-06-21

申请号：US17198939

申请日：2021-03-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Gene M. Dubowchik ,  Olafur S. Gudmundsson ,  Xiaojun Han ,  R. Michael Lawrence ,  Dasa Lipovsek ,  Cort S. Madsen ,  Claudio Mapelli ,  Paul E. Morin ,  Michael C. Myers

IPC: A61K38/22 ,  A61K38/18 ,  C07K14/64 ,  C07K1/107 ,  A61K38/00 ,  A61K47/64 ,  A61P9/00 ,  A61K45/06

Abstract: The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.

公开(公告)号：US10669261B2

公开(公告)日：2020-06-02

申请号：US16061365

申请日：2016-12-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Michael C. Myers ,  R. Michael Lawrence ,  Donna M. Bilder ,  Wei Meng ,  Zulan Pi ,  Robert Paul Brigance ,  Heather Finlay

IPC: A61K31/506 ,  A61K31/513 ,  C07D403/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P9/00

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments, in particular for treating cardiovascular disorders.

公开(公告)号：US10392347B2

公开(公告)日：2019-08-27

申请号：US15767364

申请日：2016-10-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Soong-Hoon Kim ,  Hannguang J. Chao ,  Heather Finlay ,  Ji Jiang ,  James A. Johnson ,  R. Michael Lawrence ,  Michael C. Myers ,  Monique Phillips ,  George O. Tora ,  Wei Meng

IPC: C07D213/82 ,  C07D401/06 ,  C07D401/14 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D491/107 ,  C07D498/10 ,  C07D401/12 ,  C07D471/10

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.