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公开(公告)号：US20230322726A1
公开(公告)日：2023-10-12
申请号：US18125826
申请日：2023-03-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , John Lloyd , Heather Finlay , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee , Ashokkumar Adisechan
IPC: C07D401/14 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D405/12 , C07D471/04 , C07D513/04
CPC classification number: C07D401/14 , A61K31/517 , A61K31/549 , A61K31/5377 , A61K45/06 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
Abstract: A compound of formula I
wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.-
公开(公告)号：US10590113B2
公开(公告)日：2020-03-17
申请号：US16122975
申请日：2018-09-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zulan Pi , Donna M. Bilder , Robert Paul Brigance , Heather Finlay , Wen Jiang , James A. Johnson , R. Michael Lawrence , Wei Meng , Michael C. Myers , Monique Phillips , George O. Tora , Xiaojun Zhang
IPC: A61K31/505 , C07D403/06 , C07D401/06 , C07D403/14 , C07D239/557 , C07D239/54 , C07D239/545 , C07D401/14 , C07D403/02 , C07D417/14 , C07D471/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US09822096B2
公开(公告)日：2017-11-21
申请号：US15249710
申请日：2016-08-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , Heather Finlay , James Neels , Naveen Kumar Dhondi , Ashokkumar Adisechan
IPC: C07D401/14 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D405/12 , C07D471/04 , C07D513/04
CPC classification number: C07D401/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
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公开(公告)号：US20160362396A1
公开(公告)日：2016-12-15
申请号：US15249710
申请日：2016-08-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , Heather Finlay , James Neels , Naveen Kumar , Ashokkumar Adisechan
IPC: C07D401/14 , A61K45/06 , C07D413/14 , A61K31/517
CPC classification number: C07D401/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
Abstract translation: 其中A，X，Y，Z，R 1和R 24在本文中描述。 这些化合物可用作钾通道功能的抑制剂和治疗和预防心律失常，IKur相关疾病以及由离子通道功能介导的其它病症。
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5.发明授权公开(公告)号：US09120794B2
公开(公告)日：2015-09-01
申请号：US14575171
申请日：2014-12-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lynn Abell , Leonard Adam , Cullen L. Cavallaro , Heather Finlay , Todd J. Friends , Jon J. Hangeland , Ji Jang , R. Michael Lawrence , John Lloyd , Zulan Pi , George O. Tora , Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang
IPC: C07D471/04 , C07D403/12 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/12 , C07D417/04 , C07D417/06 , C07D207/28 , C07D207/38 , C07D417/12 , C07D487/04 , C07D413/06
CPC classification number: C07D471/04 , C07D207/28 , C07D207/38 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D487/04
Abstract: The present invention provides compounds of Formula (I) or Formula (III): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）或式（III）的化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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Patent Agency Ranking
6.发明授权Amide, urea or sulfone amide linked benzothiazole inhibitors of endothelial lipase 有权酰胺，尿素或砜酰胺连接苯并噻唑抑制剂的内皮脂肪酶公开(公告)号：US08987314B2
公开(公告)日：2015-03-24
申请号：US13944921
申请日：2013-07-18
Applicant: Bristol-Myers Squibb Company
Inventor： Heather Finlay , Ji Jiang , Soong-Hoon Kim , Brandon Parkhurst , Jennifer X. Qiao , Tammy C. Wang , Zulan Pi , George O. Tora , John Lloyd , James A. Johnson
IPC: C07D277/64 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14 , A61K31/428 , A61P9/10
CPC classification number: C07D277/64 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US20140303168A1
公开(公告)日：2014-10-09
申请号：US14200063
申请日：2014-03-07
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Heather Finlay , Ashok Kumar Adisechan , Prashantha Gunaga , John Lloyd , Pothukanuri Srinivasu
IPC: C07D405/14 , C07D403/04 , C07D401/04 , A61K31/506 , C07D401/14 , A61K31/502
CPC classification number: C07D405/14 , A61K31/502 , A61K31/506 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04
Abstract: A compound of formula (I) wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
Abstract translation: 其中A，R1，R3和R24的式（I）化合物在此描述。 这些化合物可用作钾通道功能的抑制剂和治疗和预防心律失常，IKur相关疾病以及由离子通道功能介导的其它病症。
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8.发明申请公开(公告)号：US20140221357A1
公开(公告)日：2014-08-07
申请号：US14346745
申请日：2012-09-25
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lynn Abell , Leonard Adam , Cullen L. Cavallaro , Heather Finlay , Todd J. Friends , Jon J. Hangeland , Ji Jiang , R. Michael Lawrence , John Lloyd , Zulan Pi , George O. Tora , Jennifer X. Qiao , Carol Hui Hu , Tammy C. Wang
IPC: C07D207/38 , C07D417/12 , C07D471/04 , C07D417/04 , C07D401/12 , C07D403/12 , C07D403/04 , C07D487/04 , C07D403/06
CPC classification number: C07D471/04 , C07D207/28 , C07D207/38 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D487/04
Abstract: The present invention provides compounds of Formula (I) or Formula (III): [INSERT CHEMICAL STRUCTURE HERE] (I) [INSERT CHEMICAL STRUCTURE HERE] (III) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供式（I）或式（III）的化合物：[INSERT CHEMICAL Structure这里]（I）如本说明书中定义的[INSERT CHEMICAL STRUCTURE HERE]（III）和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US20220324836A1
公开(公告)日：2022-10-13
申请号：US17231088
申请日：2021-04-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , John Lloyd , Heather Finlay , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee , Ashokkumar Adisechan
IPC: C07D401/14 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D405/12 , C07D471/04 , C07D513/04
Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
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公开(公告)号：US20220315569A1
公开(公告)日：2022-10-06
申请号：US17836596
申请日：2022-06-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Wei Meng , Hannguang J. Chao , Heather Finlay , R. Michael Lawrence , Michael C. Myers
IPC: C07D413/10 , C07D239/54 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D413/06 , C07D417/06 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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