公开(公告)号：US20180297954A1

公开(公告)日：2018-10-18

申请号：US15767364

申请日：2016-10-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Soong-Hoon Kim ,  Hannguang J. Chao ,  Heather Finlay ,  Ji Jang ,  James A. Johnson ,  R. Michael Lawrence ,  Michael C. Myers ,  Monique Phillips ,  George O. Tora ,  Wei Meng

IPC: C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D401/06 ,  C07D405/14 ,  C07D417/14 ,  C07D417/12 ,  C07D498/10 ,  C07D413/12 ,  C07D491/107 ,  C07D471/10

CPC classification number: C07D213/82 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/10 ,  C07D491/107 ,  C07D498/10

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, O and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

公开(公告)号：US09120794B2

公开(公告)日：2015-09-01

申请号：US14575171

申请日：2014-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Lynn Abell ,  Leonard Adam ,  Cullen L. Cavallaro ,  Heather Finlay ,  Todd J. Friends ,  Jon J. Hangeland ,  Ji Jang ,  R. Michael Lawrence ,  John Lloyd ,  Zulan Pi ,  George O. Tora ,  Jennifer X. Qiao ,  Carol Hui Hu ,  Tammy C. Wang

IPC: C07D471/04 ,  C07D403/12 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/06 ,  C07D405/12 ,  C07D417/04 ,  C07D417/06 ,  C07D207/28 ,  C07D207/38 ,  C07D417/12 ,  C07D487/04 ,  C07D413/06

CPC classification number: C07D471/04 ,  C07D207/28 ,  C07D207/38 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D487/04

Abstract: The present invention provides compounds of Formula (I) or Formula (III): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.

Abstract translation: 本发明提供式（I）或式（III）的化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。