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公开(公告)号：US12012374B2
公开(公告)日：2024-06-18
申请号：US17610548
申请日：2020-05-07
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lalgudi S. Harikrishnan , Muthoni G. Kamau , Brian E. Fink
IPC: C07D207/12 , C07C317/22 , C07D401/06 , C07D403/06 , C07D407/06 , C07D409/06 , C07D417/06
CPC classification number: C07C317/22 , C07D207/12 , C07D401/06 , C07D403/06 , C07D407/06 , C07D409/06 , C07D417/06
Abstract: The present invention is directed to compounds of the formula wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US11660311B2
公开(公告)日：2023-05-30
申请号：US16754301
申请日：2018-10-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Brian E. Fink , Dharmpal S. Dodd , Yufen Zhao , Lan-Ying Qin , Zheming Ruan , Lalgudi S. Harikrishnan , Muthoni G. Kamau
IPC: C07H21/04 , A61K31/7084 , A61K39/395
CPC classification number: A61K31/7084 , A61K39/3955 , C07H21/04
Abstract: The present invention is directed to compounds of the formula (I), wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20180250303A1
公开(公告)日：2018-09-06
申请号：US15754311
申请日：2016-08-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Robert M. Borzilleri , Brian E. Fink , Lalgudi S. Harikrishnan , Upender Velaparthi , Vishweshwaraiah Baligar , Hasibur Rahaman , Jayakumar Sankara Warrier
CPC classification number: A61K31/52 , A61K2121/00 , A61P35/02 , C07D473/34
Abstract: The invention relates generally to compounds of formula (I) that modulate the activity of TGFβR-1 and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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公开(公告)号：US11339185B2
公开(公告)日：2022-05-24
申请号：US16683667
申请日：2019-11-14
Applicant: Bristol-Myers Squibb Company
Inventor： Brian E. Fink , Dharmpal S. Dodd , Steven J. Walker , Libing Chen , Yufen Zhao , Zheming Ruan , Lan-Ying Qin , Peter Kinam Park , Muthoni G. Kamau , Lalgudi S. Harikrishnan
IPC: C07H19/213 , A61P35/00 , C07H21/02 , C07H21/00 , C07K16/28
Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US10744150B2
公开(公告)日：2020-08-18
申请号：US16047071
申请日：2018-07-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Brian E. Fink , Dharmpal S. Dodd , Lan-ying Qin , Zheming Ruan , Yufen Zhao , Lalgudi S. Harikrishnan , Muthoni G. Kamau , Steven J. Walker
IPC: C07H19/20 , C07H19/23 , C07H19/207 , C07H19/14 , C07H21/04 , A61K31/7084 , A61P35/02 , A61P35/00 , A61K45/06
Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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Patent Agency Ranking
公开(公告)号：US10683290B2
公开(公告)日：2020-06-16
申请号：US15573141
申请日：2016-05-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Claude A. Quesnelle , Lalgudi S. Harikrishnan , Matthew D. Hill
IPC: C07D471/04 , A61P35/02
Abstract: The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US10292985B2
公开(公告)日：2019-05-21
申请号：US15755636
申请日：2016-08-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Robert M. Borzilleri , Brian E. Fink , Lalgudi S. Harikrishnan , Jayakumar Sankara Warrier
IPC: C07D487/04 , C07D519/00 , A61P35/00 , A61K31/53 , A61K35/02
Abstract: The invention relates generally to compounds that modulate the activity of TGFBETA R-1 and TGFBETA R-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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公开(公告)号：US20180127413A1
公开(公告)日：2018-05-10
申请号：US15573141
申请日：2016-05-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Claude A. QUESNELLE , Lalgudi S. Harikrishnan , Matthew D. Hill
IPC: C07D471/04 , A61P35/02
Abstract: The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20200079815A1
公开(公告)日：2020-03-12
申请号：US16683667
申请日：2019-11-14
Applicant: Bristol-Myers Squibb Company
Inventor： Brian E. FINK , Dharmpal S. Dodd , Steven J. Walker , Libing Chen , Yufen Zhao , Zheming Ruan , Lan-Ying Qin , Peter Kinam Park , Muthoni G, Kamau , Lalgudi S. Harikrishnan
IPC: C07H19/213 , A61P35/00 , C07H21/02 , C07H21/00
Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20190248828A1
公开(公告)日：2019-08-15
申请号：US16272172
申请日：2019-02-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Brian E. Fink , Dharmpal S. Dodd , Steven J. Walker , Libing Chen , Yufen Zhao , Zheming Ruan , Lan-Ying Qin , Peter Kinam Park , Muthoni G. Kamau , Lalgudi S. Harikrishnan
IPC: C07H19/213 , A61P35/00
Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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