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公开(公告)号：US20160318928A1
公开(公告)日：2016-11-03
申请号：US15107652
申请日：2014-12-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Derek J. Norris , George V. Delucca , Ashvinikumar V. Gavai , Claude A. Quesnelle , Patrice Gill , Daniel O'Malley , Wayne Vaccaro , Francis Y. Lee , Mikkel V. DeBenedetto , Andrew P. Degnan , Haiquan Fang , Matthew D. Hill , Hong Huang , William D. Schmitz , John E. Starrett, JR. , Wen-Ching Han , John S. Tokarski , Sunil Kumar Mandal
IPC: C07D471/04 , A61K31/501 , A61K31/506 , A61K31/437 , A61K31/444
CPC classification number: C07D471/04 , A61K31/437 , A61K31/444 , A61K31/501 , A61K31/506
Abstract: The present invention is directed to tricyclic compounds (I), pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20140256700A1
公开(公告)日：2014-09-11
申请号：US14190477
申请日：2014-02-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Michael A. Poss , David R. Tortolani , Dharmpal S. Dodd , Christopher P. Mussari , John S. Tokarski , Ashvinikumar V. Gavai , Yufen Zhao , George V. Delucca , Daniel O'Malley , Derek J. Norris , Patrice Gill , Claude A. Quesnelle , Wen-Ching Han
IPC: A61K31/553 , A61K31/5377 , C07D417/14 , C07D413/14 , A61K31/422 , A61K31/4192 , A61K31/496 , A61K31/427 , A61K31/5355 , A61K31/541 , C07D405/14 , C07D413/04 , A61K31/454
CPC classification number: A61K31/553 , A61K31/4192 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14
Abstract: The present invention is directed to carbazole compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
Abstract translation: 本发明涉及咔唑化合物，包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US20180079758A1
公开(公告)日：2018-03-22
申请号：US15809437
申请日：2017-11-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Douglas G. Batt , Myra Beaudoin Bertrand , George V. Delucca , Michael A. Galella , Soo Sung Ko , Charles M. Langevine , Qingjie Liu , Qing Shi , Anurag S. Srivastava , Joseph A. Tino , Scott Hunter Watterson
IPC: C07D513/04 , C07D471/04 , C07D403/10 , C07D209/88 , C07D239/70
CPC classification number: C07D513/04 , C07B2200/07 , C07B2200/13 , C07D209/88 , C07D239/70 , C07D403/10 , C07D471/04
Abstract: Disclosed are compounds of Formula (I) wherein: the two dotted lines represent either two single or two double bonds; Q is: R1 is F, Cl, —CN, or —CH3; R2 is Cl or —CH3; R3 is —C(CH3)2OH or —CH2CH2OH; Ra is H or —CH3; each Rb is independently F, Cl, —CH3, and/or —OCH3; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
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公开(公告)号：US20160176864A1
公开(公告)日：2016-06-23
申请号：US14580355
申请日：2014-12-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Derek J. Norris , George V. Delucca , Ashvinikumar V. Gavai , Claude A. Quesnelle , Patrice Gill , Daniel O'Malley , Wayne Vaccaro , Francis Y. Lee , Mikkel V. DeBenedetto , Andrew P. Degnan , Haiquan Fang , Matthew D. Hill , Hong Huang , William D. Schmitz , John E. Starrett, JR. , Wen-Ching Han , John S. Tokarski , Sunil Kumar Mandal
IPC: C07D471/04 , A61K31/437
CPC classification number: C07D471/04 , A61K31/437 , A61K45/06 , A61K2300/00
Abstract: The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US10106559B2
公开(公告)日：2018-10-23
申请号：US15809437
申请日：2017-11-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Douglas G. Batt , Myra Beaudoin Bertrand , George V. Delucca , Michael A. Galella , Soo Sung Ko , Charles M. Langevine , Qingjie Liu , Qing Shi , Anurag S. Srivastava , Joseph A. Tino , Scott Hunter Watterson
IPC: C07D513/04 , C07D471/04 , C07D403/10 , C07D239/70 , C07D209/88
Abstract: Disclosed are compounds of Formula (I) wherein: the two dotted lines represent either two single or two double bonds; Q is: R1 is F, Cl, —CN, or —CH3; R2 is Cl or —CH3; R3 is —C(CH3)2OH or —CH2CH2OH; Ra is H or —CH3; each Rb is independently F, Cl, —CH3, and/or —OCH3; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
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Patent Agency Ranking
公开(公告)号：US09725449B2
公开(公告)日：2017-08-08
申请号：US15150492
申请日：2016-05-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Derek J. Norris , Wayne Vaccaro , Mikkel V. DeBenedetto , Andrew P. Degnan , George V. Delucca , Jeffrey A. Deskus , Wen-Ching Han , Godwin Kwame Kumi , William D. Schmitz , John E. Starrett, Jr. , Matthew D. Hill , Hong Huang
IPC: C07D471/14 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/554 , A61K31/675 , A61K31/683 , C07D519/00 , C07F9/6561
CPC classification number: C07D471/14 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/554 , A61K31/675 , A61K31/683 , C07D519/00 , C07F9/6561
Abstract: The present invention is directed to tricyclic compounds of the formula wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20160194338A1
公开(公告)日：2016-07-07
申请号：US15067915
申请日：2016-03-11
Applicant: Bristol-Myers Squibb Company
Inventor： Douglas G. Batt , Myra Beaudoin Bertrand , George V. Delucca , Michael A. Galella , Soo Sung Ko , Charles M. Langevine , Qingjie Liu , Qing Shi , Anurag S. Srivastava
IPC: C07D513/04 , C07D471/04 , C07D403/10
CPC classification number: C07D513/04 , C07B2200/07 , C07B2200/13 , C07D209/88 , C07D239/70 , C07D403/10 , C07D471/04
Abstract: Disclosed are compounds of Formula (I) wherein: the two dotted lines represent either two single or two double bonds; Q is: R1 is F, Cl, —CN, or —CH3; R2 is C1 or —CH3; R3 is —C(CH3)2OH or —CH2CH2OH; Ra is H or —CH3; each Rb is independently F, Cl, —CH3, and/or —OCH3; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
Abstract translation: 公开了式（I）的化合物，其中：两条虚线表示两个单键或双键; Q是：R1是F，Cl，-CN或-CH3; R2是C1或-CH3; R3是-C（CH3）2OH或-CH2CH2OH; Ra为H或-CH 3; 每个R b独立地是F，Cl，-CH 3和/或-OCH 3; 并且n为0,1或2.还公开了使用这种化合物作为Bruton酪氨酸激酶（Btk）的抑制剂的方法和包含这些化合物的药物组合物。 这些化合物可用于治疗，预防或减缓各种治疗领域（例如自身免疫疾病和血管疾病）中的疾病或病症的进展。
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公开(公告)号：US20170327498A1
公开(公告)日：2017-11-16
申请号：US15661373
申请日：2017-07-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Derek J. Norris , George V. Delucca , Ashvinikumar V. Gavai , Francis Y. Lee , John S. Tokarski
IPC: C07D471/04 , A61K31/437
CPC classification number: C07D471/04 , A61K31/437 , A61K45/06 , A61K2300/00
Abstract: The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US09458156B2
公开(公告)日：2016-10-04
申请号：US14580355
申请日：2014-12-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Derek J. Norris , George V. Delucca , Ashvinikumar V. Gavai , Francis Y. Lee , John S. Tokarski
IPC: C07D471/04 , A61K31/437
CPC classification number: C07D471/04 , A61K31/437 , A61K45/06 , A61K2300/00
Abstract: The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
Abstract translation: 本发明涉及三环化合物，包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US10112941B2
公开(公告)日：2018-10-30
申请号：US15661373
申请日：2017-07-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Derek J. Norris , George V. Delucca , Ashvinikumar V. Gavai , Francis Y. Lee , John S. Tokarski
IPC: C07D471/04 , A61K31/437
Abstract: The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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