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公开(公告)号：US20160009701A1
公开(公告)日：2016-01-14
申请号：US14770230
申请日：2014-02-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Michael A. Poss , David R. Tortolani , Ashok Vinayak Purandare , John S. Tokarski , Christopher P. Mussari , Muthoni G. Kamau , Dharmpal S. Dodd , Ashvinikumar V. Gavai , Daniel O'Malley , Tram N. Huynh , Wayne Vaccaro , Lalgudi S. Harikrishnan
IPC: C07D413/10 , A61K31/5377 , C07D413/14 , A61K31/422 , A61K31/5355 , A61K31/553 , C07D417/14 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/541
CPC classification number: C07D413/10 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K31/553 , C07D413/04 , C07D413/14 , C07D417/14
Abstract: The present invention is directed to carbazole compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
Abstract translation: 本发明涉及咔唑化合物，包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US09725449B2
公开(公告)日：2017-08-08
申请号：US15150492
申请日：2016-05-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Derek J. Norris , Wayne Vaccaro , Mikkel V. DeBenedetto , Andrew P. Degnan , George V. Delucca , Jeffrey A. Deskus , Wen-Ching Han , Godwin Kwame Kumi , William D. Schmitz , John E. Starrett, Jr. , Matthew D. Hill , Hong Huang
IPC: C07D471/14 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/554 , A61K31/675 , A61K31/683 , C07D519/00 , C07F9/6561
CPC classification number: C07D471/14 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/554 , A61K31/675 , A61K31/683 , C07D519/00 , C07F9/6561
Abstract: The present invention is directed to tricyclic compounds of the formula wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US10053454B2
公开(公告)日：2018-08-21
申请号：US14770230
申请日：2014-02-27
Applicant: Bristol-Myers Squibb Company
Inventor： Michael A. Poss , David R. Tortolani , Ashok Vinayak Purandare , John S. Tokarski , Christopher P. Mussari , Muthoni G. Kamau , Dharmpal S. Dodd , Ashvinikumar V. Gavai , Daniel O'Malley , Tram N. Huynh , Wayne Vaccaro , Lalgudi S. Harikrishnan
IPC: C07D413/04 , C07D413/10 , C07D413/14 , C07D417/14 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K31/553
CPC classification number: C07D413/10 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K31/553 , C07D413/04 , C07D413/14 , C07D417/14
Abstract: The present invention is directed to carbazole compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：US20160318928A1
公开(公告)日：2016-11-03
申请号：US15107652
申请日：2014-12-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Derek J. Norris , George V. Delucca , Ashvinikumar V. Gavai , Claude A. Quesnelle , Patrice Gill , Daniel O'Malley , Wayne Vaccaro , Francis Y. Lee , Mikkel V. DeBenedetto , Andrew P. Degnan , Haiquan Fang , Matthew D. Hill , Hong Huang , William D. Schmitz , John E. Starrett, JR. , Wen-Ching Han , John S. Tokarski , Sunil Kumar Mandal
IPC: C07D471/04 , A61K31/501 , A61K31/506 , A61K31/437 , A61K31/444
CPC classification number: C07D471/04 , A61K31/437 , A61K31/444 , A61K31/501 , A61K31/506
Abstract: The present invention is directed to tricyclic compounds (I), pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20160108050A1
公开(公告)日：2016-04-21
申请号：US14976476
申请日：2015-12-21
Applicant: Bristol-Myers Squibb Company
Inventor： Ashok Vinayak Purandare , Brian E. Fink , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer lnghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann , Yong Zhang , Libing Chen , Bin Chen , John S. Tokarski , Ashvinikumar V. Gavai
IPC: C07D487/04 , C07F9/6561 , C07F7/18 , C07D519/00
CPC classification number: C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
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Patent Agency Ranking
公开(公告)号：US09751879B2
公开(公告)日：2017-09-05
申请号：US15219611
申请日：2016-07-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Derek J. Norris , George V. Delucca , Ashvinikumar V. Gavai , Claude A. Quesnelle , Patrice Gill , Daniel O'Malley , Wayne Vaccaro , Francis Y. Lee , Mikkel V. DeBenedetto , Andrew P. Degnan , Haiquan Fang , Matthew D. Hill , Hong Huang , William D. Schmitz , John E. Starrett, Jr. , Wen-Ching Han , John S. Tokarski , Sunil Kumar Mandal
IPC: C07D471/04 , A61K31/437
CPC classification number: C07D471/04 , A61K31/437 , A61K45/06 , A61K2300/00
Abstract: The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20160333013A1
公开(公告)日：2016-11-17
申请号：US15150492
申请日：2016-05-10
Applicant: Bristol-Myers Squibb Company
Inventor： Derek J. Norris , Wayne Vaccaro , Mikkel V. DeBenedetto , Andrew P. Degnan , George V. Delucca , Jeffrey A. Deskus , Wen-Ching Han , Godwin Kwame Kumi , William D. Schmitz , John E. Starrett, JR. , Matthew D. Hill , Hong Huang
IPC: C07D471/14 , A61K31/5377 , A61K31/496 , A61K31/444 , A61K31/541 , A61K31/675 , A61K31/4545 , C07D519/00 , A61K31/439 , A61K31/554 , C07F9/6561 , A61K31/683 , A61K31/4375 , A61K31/519
CPC classification number: C07D471/14 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/554 , A61K31/675 , A61K31/683 , C07D519/00 , C07F9/6561
Abstract: The present invention is directed to tricyclic compounds of the formula wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
Abstract translation: 其中所有取代基在本文中定义，以及包含本发明化合物的药学上可接受的组合物以及使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US20160326173A1
公开(公告)日：2016-11-10
申请号：US15219611
申请日：2016-07-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Derek J. Norris , George V. Delucca , Ashvinikumar V. Gavai , Claude A. Quesnelle , Patrice Gill , Daniel O'Malley , Wayne Vaccaro , Francis Y. Lee , Mikkel V. DeBenedetto , Andrew P. Degnan , Haiquan Fang , Matthew D. Hill , Hong Huang , William D. Schmitz , John E. Starrett, JR. , Wen-Ching Han , John S. Tokarski , Sunil Kumar Mandal
IPC: C07D471/04 , A61K31/437
CPC classification number: C07D471/04 , A61K31/437 , A61K45/06 , A61K2300/00
Abstract: The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
Abstract translation: 本发明涉及三环化合物，包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US20150210697A1
公开(公告)日：2015-07-30
申请号：US14414152
申请日：2013-07-12
Applicant: Bristol-Myers Squibb Company
Inventor： Ashok Vinayak Purandare , Brian E. Fink , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer Inghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann , Yong Zhang , Libing Chen , Bin Chen , John S. Tokarski , Ashvinikumar V. Gavai
IPC: C07D487/04 , C07F7/18 , C07D487/10 , C07D487/08 , C07D471/10
CPC classification number: C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
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公开(公告)号：US08940736B2
公开(公告)日：2015-01-27
申请号：US13940619
申请日：2013-07-12
Applicant: Bristol-Myers Squibb Company
Inventor： Ashok Vinayak Purandare , Brian E. Fink , Ashvinikumar V. Gavai , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer Inghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann
IPC: A61K31/535 , A01N43/00 , A61K31/00 , A01N57/00 , A61K31/675 , C07D413/00 , C07D487/00 , C07D243/08 , A61K31/53 , A61K45/06 , A61K31/5377 , C07D471/10 , C07D487/10 , C07D498/04 , A61K31/551 , C07D487/04 , A61K31/5383 , C07F9/6521
CPC classification number: C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）咪唑三嗪抑制蛋白激酶活性，从而使它们用作抗癌剂。
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