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公开(公告)号：US12269030B2
公开(公告)日：2025-04-08
申请号：US17631461
申请日：2021-03-03
Applicant: BOE Technology Group Co., Ltd.
Inventor： Yudan Yin , Jing Yu , Haonan Liu , Zhukai Liu
Abstract: Disclosed are a detection chip and a modification method therefor. A surface activation treatment is performed on a hydrophilic layer of the detection chip, such that a hydroxy-containing modification group is formed on a surface of the hydrophilic layer; and a solution containing an oxy compound is then used to perform a surface epoxidation treatment on the hydrophilic layer in order to form an epoxy-containing modification group on the surface of the hydrophilic layer.
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公开(公告)号：US11904316B2
公开(公告)日：2024-02-20
申请号：US17255981
申请日：2020-05-15
Applicant: BOE TECHNOLOGY GROUP CO., LTD.
Inventor： Yudan Yin
IPC: B01L1/00 , B01L3/00 , B01L9/00 , G01N33/543
CPC classification number: B01L3/502715 , B01L9/527 , G01N33/54346 , B01L2200/10 , B01L2300/161
Abstract: The present disclosure provides a microfluidic chip, including: a support and an NFC coil in the support, and a flow path is provided in the support and is isolated from the NFC coil; the flow path includes at least one detection window region with a stationary phase therein, and the stationary phase is used to specifically capture a target analyte, the detection window region at least partially overlaps with the NFC coil in a thickness direction of the support. The present disclosure further provides a detection method of the microfluidic chip and a micro total analysis system. The present disclosure can quickly and immediately obtain a detection result.
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公开(公告)号：US11883822B2
公开(公告)日：2024-01-30
申请号：US17254984
申请日：2020-03-31
Inventor： Zijian Zhao , Mengjun Hou , Yudan Yin
CPC classification number: B01L3/502784 , B01L7/525 , G01N21/6456 , G01N21/6486 , B01L2200/148 , B01L2300/0816 , B01L2300/0867 , B01L2300/1827 , B01L2400/0487
Abstract: A reaction device for a detection chip and a reaction system are provided. The reaction device includes a chip carrier and an electrical signal control unit. The chip carrier is configured to place and fix the detection chip; and the electrical signal control unit is configured to apply an electrical signal to the detection chip so as to drive a heating electrode of the detection chip.
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公开(公告)号：US12036555B2
公开(公告)日：2024-07-16
申请号：US17736817
申请日：2022-05-04
Applicant: BOE TECHNOLOGY GROUP CO., LTD.
Inventor： Zhihong Wu , Defeng Mao , Zijian Zhao , Yudan Yin
CPC classification number: B01L3/502761 , B32B3/30 , B32B37/18 , B01L2200/027 , B01L2200/0652 , B01L2200/12
Abstract: A microfluidic particle sorting apparatus for capturing targets from fluid containing the targets is disclosed. The apparatus includes an inlet for receiving the fluid; a sorting chamber allowing the fluid to flow through; a first outlet for discharging the fluid after flowing through the sorting chamber; a capturing structure for capturing the cells, wherein the capturing structure is upstream of the first outlet, and includes obstacles in an array, each extending through the sorting chamber in a lateral direction with respect to a fluid flow of the fluid; and a second outlet upstream of the capturing structure comprising a plurality of openings; wherein a gap between two adjacent obstacles is equal to or greater than each opening of the second outlet.
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公开(公告)号：US11338292B2
公开(公告)日：2022-05-24
申请号：US16624813
申请日：2019-03-12
Applicant: BOE TECHNOLOGY GROUP CO., LTD.
Inventor： Zhihong Wu , Defeng Mao , Zijian Zhao , Yudan Yin
Abstract: A microfluidic particle sorting apparatus for capturing targets from fluid containing the targets is disclosed. The apparatus includes an inlet for receiving the fluid; a sorting chamber allowing the fluid to flow through; a first outlet for discharging the fluid after flowing through the sorting chamber; a capturing structure for capturing the cells, wherein the capturing structure is upstream of the first outlet, and includes obstacles in an array, each extending through the sorting chamber in a lateral direction with respect to a fluid flow of the fluid; and a second outlet upstream of the capturing structure comprising a plurality of openings; wherein a gap between two adjacent obstacles is equal to or greater than each opening of the second outlet.
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Patent Agency Ranking
6.发明授权公开(公告)号：US11591370B2
公开(公告)日：2023-02-28
申请号：US16646320
申请日：2019-08-22
Inventor： Zijian Zhao , Yudan Yin
Abstract: A peptoid compound, a manufacturing method of a peptoid compound, an oligomer, a pharmaceutical composition, use of the pharmaceutical composition in the preparation of a medicament for detecting or diagnosing a disease related to tyrosine kinase HER2, and a kit for identifying circulating tumor cells are provided, the peptoid compound includes: a cysteine (Cys) subunit, a butanediamine (Nlys) subunit, a 3,4-methylenedioxybenzylamine (Npip) subunit, a 3-aminopropanic acid (Nce) subunit and a 1-naphthylamine (Na) subunit, and both the peptoid compound and the oligomer have a strong ability to bind to HER2 protein on surfaces of circulating tumor cells (CTCs), and a technology of diagnosing breast cancer on the basis of the peptoid compound can realize non-invasive and label-free rapid diagnosis, in addition, the methods for synthesizing the peptoid compound and the oligomer are simple, the preparation efficiency is high, and the production cost is low.
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公开(公告)号：US11559476B2
公开(公告)日：2023-01-24
申请号：US16913323
申请日：2020-06-26
Applicant: BOE Technology Group Co., Ltd.
Inventor： Yudan Yin
Abstract: The present application provides a method for preparing a hydrogel and the obtained hydrogel. The method including: forming a first part by mixing a first single-stranded nucleotide with a first liposome, and forming a second part by mixing a second single-stranded nucleotide with a second liposome, wherein the first single-stranded nucleotide and the second single-stranded nucleotide have complementary sticky ends; forming a hydrogel by mixing the first part and the second part.
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公开(公告)号：US12280369B2
公开(公告)日：2025-04-22
申请号：US18112671
申请日：2023-02-22
Inventor： Zhihong Wu , Zijian Zhao , Yudan Yin , Mengjun Hou , Kang Peng
Abstract: A detection chip, a using method for the same, and a reaction system. The detection chip includes a first substrate, a micro-cavity defining layer, and a heating electrode. The micro-cavity defining layer is on the first substrate and defines a plurality of micro-reaction chambers. The heating electrode is on the first substrate and is closer to the first substrate than the micro-cavity defining layer, and is configured to heat a plurality of micro-reaction chambers. The orthographic projection of the plurality of micro-reaction chambers on the first substrate is within the orthographic projection of the heating electrode on the first substrate.
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公开(公告)号：US11913947B2
公开(公告)日：2024-02-27
申请号：US17355338
申请日：2021-06-23
Applicant: BOE TECHNOLOGY GROUP CO., LTD.
Inventor： Haonan Liu , Yudan Yin , Ding Ding
IPC: G01N33/68 , G01N21/33 , G01N21/64 , G01N33/52 , C07C309/65 , C07C309/73 , A01N1/02 , G01N1/40 , G01N33/543 , B01L3/00
CPC classification number: G01N33/5438 , B01L3/502707 , B01L3/502715 , B01L2200/12 , B01L2300/0819 , B01L2300/12 , B01L2300/165
Abstract: The present disclosure provides a digital immunochip and a manufacture method thereof. The digital immunochip includes a first substrate and a second substrate which are opposite to each other. The first substrate includes: a first base substrate; at least one driving electrode on the first base substrate and configured to drive an object to be detected to move; a dielectric layer on a side of the at least one driving electrode away from the first base substrate and covering the at least one driving electrode; and a first hydrophobic layer on a side of the dielectric layer away from the first base substrate. The second substrate includes: a second base substrate; and an immunoassay substance on a side of the second base substrate proximal to the first hydrophobic layer of the first substrate and including an antigen or an antibody.
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公开(公告)号：US11654435B2
公开(公告)日：2023-05-23
申请号：US16753115
申请日：2019-03-29
Inventor： Zijian Zhao , Siyi Yin , Yudan Yin
CPC classification number: B01L7/52 , B01L3/50273 , B01L3/502715 , C12Q1/686 , B01L2300/08 , B01L2300/165 , B01L2300/1805 , B01L2400/088
Abstract: The detection chip includes a first substrate, a micro-cavity defining layer, a hydrophilic layer, and a hydrophobic layer. The micro-cavity defining layer is on the first substrate and defines a plurality of micro-reaction chambers. Each of the plurality of micro-reaction chambers includes a reaction trap, and the reaction trap includes a sidewall and a bottom. The micro-cavity defining layer includes a spacing region between the plurality of micro-reaction chambers, and the spacing region includes a first region adjacent to the sidewall, and a second region non-adjacent to the sidewall. The hydrophilic layer covers the sidewall and the bottom of each of the plurality of micro-reaction chambers, and the hydrophobic layer covers the second region.
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