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公开(公告)号：US12188937B2
公开(公告)日：2025-01-07
申请号：US16977270
申请日：2019-11-29
Inventor： Zijian Zhao , Siyi Yin
IPC: G01N33/574 , C07C233/36 , C07K7/04 , C40B40/10 , G01N33/68
Abstract: Embodiments disclosed herein provide a peptoid compound comprising a structure shown in Formula I and a detection chip having the peptoid compound coupled onto its surface. The peptoid compound has a strong binding ability with EpCAM protein on the surface of circulating tumor cells. The diagnostic technology of colorectal adenocarcinoma, gastric adenocarcinoma, breast cancer, ovarian cancer, lung adenocarcinoma, prostate cancer, pancreatic cancer, stem cell cancer, retinoblastoma, or primary esophageal squamous cell carcinoma based on the peptoid compound can realize rapid detection or diagnosis. In addition, the peptoid compound can be made by a simple synthesis method with high preparation efficiency and low production cost.
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公开(公告)号：US10941180B2
公开(公告)日：2021-03-09
申请号：US16248263
申请日：2019-01-15
Applicant: BOE Technology Group Co., Ltd.
Inventor： Zijian Zhao
Abstract: The present disclosure relates to a peptoid compound, and a derivative, a salt, a preparation method and use thereof. The peptoid compound includes the following subunits: 4-phenylphenethylamine, monoprotected ethylenediamine, monoprotected tetramethylenediamine, 3,4-methylenedioxybenzylamine, isobutylamine, and R(+)-α-methylbenzylamine, in which molecular formulas of the subunits are as follows: in which P is independently an amino protecting group.
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公开(公告)号：US11883822B2
公开(公告)日：2024-01-30
申请号：US17254984
申请日：2020-03-31
Inventor： Zijian Zhao , Mengjun Hou , Yudan Yin
CPC classification number: B01L3/502784 , B01L7/525 , G01N21/6456 , G01N21/6486 , B01L2200/148 , B01L2300/0816 , B01L2300/0867 , B01L2300/1827 , B01L2400/0487
Abstract: A reaction device for a detection chip and a reaction system are provided. The reaction device includes a chip carrier and an electrical signal control unit. The chip carrier is configured to place and fix the detection chip; and the electrical signal control unit is configured to apply an electrical signal to the detection chip so as to drive a heating electrode of the detection chip.
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公开(公告)号：US11691150B2
公开(公告)日：2023-07-04
申请号：US16753950
申请日：2019-09-30
Inventor： Zhihong Wu , Zijian Zhao
IPC: B01L3/00 , C12Q1/6869
CPC classification number: B01L3/508 , C12Q1/6869 , B01L2200/12 , B01L2300/0819 , B01L2300/12 , B01L2400/0415
Abstract: A biological chip, a manufacturing method thereof, an operation method thereof, and a biological detection system are provided. The biological chip includes a base substrate and a plurality of working units. The plurality of the working units are arranged on the base substrate; each of the working units includes a working element configured to be in contact with a target substance; and the working element includes a metal electrode and an electric-field-controllable surface modification layer on a surface of the metal electrode.
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公开(公告)号：US12280369B2
公开(公告)日：2025-04-22
申请号：US18112671
申请日：2023-02-22
Inventor： Zhihong Wu , Zijian Zhao , Yudan Yin , Mengjun Hou , Kang Peng
Abstract: A detection chip, a using method for the same, and a reaction system. The detection chip includes a first substrate, a micro-cavity defining layer, and a heating electrode. The micro-cavity defining layer is on the first substrate and defines a plurality of micro-reaction chambers. The heating electrode is on the first substrate and is closer to the first substrate than the micro-cavity defining layer, and is configured to heat a plurality of micro-reaction chambers. The orthographic projection of the plurality of micro-reaction chambers on the first substrate is within the orthographic projection of the heating electrode on the first substrate.
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Patent Agency Ranking
公开(公告)号：US11654435B2
公开(公告)日：2023-05-23
申请号：US16753115
申请日：2019-03-29
Inventor： Zijian Zhao , Siyi Yin , Yudan Yin
CPC classification number: B01L7/52 , B01L3/50273 , B01L3/502715 , C12Q1/686 , B01L2300/08 , B01L2300/165 , B01L2300/1805 , B01L2400/088
Abstract: The detection chip includes a first substrate, a micro-cavity defining layer, a hydrophilic layer, and a hydrophobic layer. The micro-cavity defining layer is on the first substrate and defines a plurality of micro-reaction chambers. Each of the plurality of micro-reaction chambers includes a reaction trap, and the reaction trap includes a sidewall and a bottom. The micro-cavity defining layer includes a spacing region between the plurality of micro-reaction chambers, and the spacing region includes a first region adjacent to the sidewall, and a second region non-adjacent to the sidewall. The hydrophilic layer covers the sidewall and the bottom of each of the plurality of micro-reaction chambers, and the hydrophobic layer covers the second region.
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公开(公告)号：US11370813B2
公开(公告)日：2022-06-28
申请号：US16642572
申请日：2019-10-10
Inventor： Zijian Zhao
Abstract: The embodiments disclosed herein provide a peptoid, which is a compound of Formula I or a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof. N—R4, N—R3, N—R2, and N—R1 in Formula I are respectively. The peptoid has a strong binding ability with EGFR protein. It can be used not only for targeted treatment of diseases associated with EGFR protein, but also for imaging detection or prognosis monitoring of diseases associated with EGFR protein.
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公开(公告)号：US12036555B2
公开(公告)日：2024-07-16
申请号：US17736817
申请日：2022-05-04
Applicant: BOE TECHNOLOGY GROUP CO., LTD.
Inventor： Zhihong Wu , Defeng Mao , Zijian Zhao , Yudan Yin
CPC classification number: B01L3/502761 , B32B3/30 , B32B37/18 , B01L2200/027 , B01L2200/0652 , B01L2200/12
Abstract: A microfluidic particle sorting apparatus for capturing targets from fluid containing the targets is disclosed. The apparatus includes an inlet for receiving the fluid; a sorting chamber allowing the fluid to flow through; a first outlet for discharging the fluid after flowing through the sorting chamber; a capturing structure for capturing the cells, wherein the capturing structure is upstream of the first outlet, and includes obstacles in an array, each extending through the sorting chamber in a lateral direction with respect to a fluid flow of the fluid; and a second outlet upstream of the capturing structure comprising a plurality of openings; wherein a gap between two adjacent obstacles is equal to or greater than each opening of the second outlet.
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公开(公告)号：US11971413B2
公开(公告)日：2024-04-30
申请号：US16753970
申请日：2019-10-10
Inventor： Zijian Zhao
IPC: C07K7/06 , A61K38/00 , C07K1/06 , G01N33/543 , G01N33/574 , G01N33/58
CPC classification number: G01N33/57492 , C07K1/061 , C07K7/06 , G01N33/54366 , G01N33/582 , A61K38/00
Abstract: The embodiments disclosed herein provide a peptoid, which is a compound of Formula I or a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof. N—R4, N—R3, N—R2, and N—R1 in Formula I are
respectively. The peptoid has a strong binding ability with an EpCAM protein. It can be used as molecular probes for diseases associated with an EpCAM protein, to achieve targeted therapy, in vivo imaging diagnosis and prognosis monitoring of the diseases associated with the EpCAM protein at low cost, high accuracy and high efficiency.-
公开(公告)号：US11338292B2
公开(公告)日：2022-05-24
申请号：US16624813
申请日：2019-03-12
Applicant: BOE TECHNOLOGY GROUP CO., LTD.
Inventor： Zhihong Wu , Defeng Mao , Zijian Zhao , Yudan Yin
Abstract: A microfluidic particle sorting apparatus for capturing targets from fluid containing the targets is disclosed. The apparatus includes an inlet for receiving the fluid; a sorting chamber allowing the fluid to flow through; a first outlet for discharging the fluid after flowing through the sorting chamber; a capturing structure for capturing the cells, wherein the capturing structure is upstream of the first outlet, and includes obstacles in an array, each extending through the sorting chamber in a lateral direction with respect to a fluid flow of the fluid; and a second outlet upstream of the capturing structure comprising a plurality of openings; wherein a gap between two adjacent obstacles is equal to or greater than each opening of the second outlet.
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