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公开(公告)号：US20160362652A1
公开(公告)日：2016-12-15
申请号：US15245524
申请日：2016-08-24
Applicant: BIOVEST INTERNATIONAL, INC.
Inventor： DARRELL PAUL PAGE , ROBERT J. WOJCIECHOWSKI , MARTIN PEDER CREP
Abstract: An extra-capillary fluid cycling unit for maintaining and cycling fluid volumes in a cell culture chamber includes a housing and a first flexible reservoir extra-capillary fluid reservoir disposed in the housing. The extra-capillary fluid reservoir is in fluid communication with a cell culture chamber. A second flexible reservoir is also located in the housing, the second flexible reservoir being in fluid communication with a pressure source. A sensor plate is movably disposed in the housing between the extra-capillary reservoir and the second reservoir, wherein the second reservoir is pressurized to move the sensor plate in relation to the extra-capillary reservoir to cause fluid cycling and maintain fluid volumes in the cell growth chamber.
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2.发明申请公开(公告)号：US20160362650A1
公开(公告)日：2016-12-15
申请号：US15245601
申请日：2016-08-24
Applicant: BIOVEST INTERNATIONAL, INC.
Inventor： ROBERT J. WOJCIECHOWSKI , DARRELL P. PAGE , KARL PATRICK BONGERS , SCOTT WANIGER , BEVERLY NORRIS , MARK HIRSCHEL , THIEM CHAN DUONG WONG , GRANT ADAMS , MARTIN PEDER CREP , MICHAEL J. GRAMER
IPC: C12M1/00 , C12M3/00 , C12M1/36 , F04B43/00 , C12M1/26 , A61K35/12 , F04B43/12 , C12M1/34 , C12M1/02
Abstract: A cell culture system for the production of cells and cell derived products includes a reusable instrumentation base device incorporating hardware to support cell culture growth. A disposable cultureware module including a cell growth chamber is removably attachable to the instrumentation base device. The base device includes microprocessor control and a pump for circulating cell culture medium through the cell growth chamber. The cultureware module is removably attached to the instrumentation base device. Cells are introduced into the cell growth chamber and a source of medium is fluidly attached to the cultureware module. Operating parameters are programmed into the microprocessor control. The pump is operated to circulate the medium through the cell growth chamber to grow cells or cell products therein. The grown cells or cell products are harvested from the cell growth chamber and the cultureware module is then disposed.
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公开(公告)号：US20180155752A1
公开(公告)日：2018-06-07
申请号：US15885608
申请日：2018-01-31
Applicant: BIOVEST INTERNATIONAL, INC.
Inventor： MARK HIRSCHEL , ROBERT J. WOJCIECHOWSKI , GRANT ADAMS , DARRELL P. PAGE , KIMBERLY ARNESON , JEFF JORGENSEN , SCOTT WANIGER
CPC classification number: C12P21/00 , A61K39/00 , C07K16/065 , C12M41/48
Abstract: The subject invention pertains to methods and apparatus for the production and purification of cell products, such as immunoglobulins. One aspect of the invention is an integrated cell culture and purification apparatus for the growth and maintenance of cells and the harvest and purification of cell products, such as immunoglobulins. Thus, the apparatus integrates a cell culture function with a purification function. Other aspects of the invention pertain to an automated method for producing immunogenic compositions such as vaccines.
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Patent Agency Ranking
公开(公告)号：US20150111252A1
公开(公告)日：2015-04-23
申请号：US14516868
申请日：2014-10-17
Applicant: BIOVEST INTERNATIONAL, INC.
Inventor： MARK HIRSCHEL , ROBERT J. WOJCIECHOWSKI , MICHAEL J. GRAMER , GRANT ADAMS , DARRELL P. PAGE , CHAD SINKLER , KEVIN TACHENY , KIMBERLY ARNESON , JEFF JORGENSEN , SCOTT WANIGER
IPC: C12P21/00
CPC classification number: C12P21/00 , A61K39/00 , C07K16/065 , C12M41/48
Abstract: The subject invention pertains to methods and apparatus for the production and purification of cell products, such as immunoglobulins. One aspect of the invention is an integrated cell culture and purification apparatus for the growth and maintenance of cells and the harvest and purification of cell products, such as immunoglobulins. Thus, the apparatus integrates a cell culture function with a purification function. Other aspects of the invention pertain to an automated method for producing immunogenic compositions such as vaccines.
Abstract translation: 本发明涉及用于细胞产物如免疫球蛋白的生产和纯化的方法和装置。 本发明的一个方面是用于细胞生长和维持以及细胞产物如免疫球蛋白的收获和纯化的综合细胞培养和纯化装置。 因此，该装置将细胞培养功能与纯化功能相结合。 本发明的其它方面涉及用于产生免疫原性组合物如疫苗的自动化方法。
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公开(公告)号：US20130058907A1
公开(公告)日：2013-03-07
申请号：US13664048
申请日：2012-10-30
Applicant: Biovest International, Inc.
Inventor： ROBERT J. WOJCIECHOWSKI , DARRELL P. PAGE , KARL PATRICK BONGERS , SCOTT WANIGER , BEVERLY NORRIS , MARK HIRSCHEL , THIEM CHAN DUONG WONG , GRANT ADAMS , MARTIN PEDER CREP , MICHAEL J. GRAMER
CPC classification number: C12M41/40 , A61K35/12 , C12M23/26 , C12M23/28 , C12M23/34 , C12M23/44 , C12M23/58 , C12M25/10 , C12M27/00 , C12M29/00 , C12M29/10 , C12M29/18 , C12M33/14 , C12M41/20 , C12M41/26 , C12M41/34 , C12M41/38 , C12M41/48 , C12M47/04 , C12M47/10 , C12M47/12 , C12M47/20 , C12Q3/00 , F04B43/0072 , F04B43/09 , F04B43/12 , F04B43/1292
Abstract: A cell culture system for the production of cells and cell derived products includes a reusable instrumentation base device incorporating hardware to support cell culture growth. A disposable cultureware module including a cell growth chamber is removably attachable to the instrumentation base device. The base device includes microprocessor control and a pump for circulating cell culture medium through the cell growth chamber. The cultureware module is removably attached to the instrumentation base device. Cells are introduced into the cell growth chamber and a source of medium is fluidly attached to the cultureware module. Operating parameters are programmed into the microprocessor control. The pump is operated to circulate the medium through the cell growth chamber to grow cells or cell products therein. The grown cells or cell products are harvested from the cell growth chamber and the cultureware module is then disposed.
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6.发明申请公开(公告)号：US20180155668A1
公开(公告)日：2018-06-07
申请号：US15885186
申请日：2018-01-31
Applicant: BIOVEST INTERNATIONAL, INC.
Inventor： MARK HIRSCHEL , ROBERT J. WOJCIECHOWSKI , KIM ARNESON
CPC classification number: C12M23/44 , C12M23/00 , C12M23/42 , C12M23/52 , C12M25/10 , C12M41/00 , C12M41/14 , C12M41/48 , C12P21/02
Abstract: The present invention provides a production module for large-scale production of cells and/or cell-derived products such as antibodies or virus; a production suite comprising a plurality of functionally connected production modules of the invention; and a method for large-scale production of cells and/or cell-derived products using the production modules and/or production suites of the invention.
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公开(公告)号：US20150175950A1
公开(公告)日：2015-06-25
申请号：US14528007
申请日：2014-10-30
Applicant: BIOVEST INTERNATIONAL, INC.
Inventor： MARK HIRSCHEL , ROBERT J. WOJCIECHOWSKI , JOSEPH DAVID GANGEMI , SCOTT WANIGER , KEVIN TACHENY , CHAD SINKLER , DARRELL P. PAGE , JEFF JORGENSEN , MICHAEL J. GRAMER , KIMBERLY ARNESON , GRANT ADAMS
CPC classification number: C12M23/28 , C12M23/34 , C12M23/44 , C12M25/10 , C12M29/04 , C12M41/12 , C12M41/32 , C12M41/48 , C12M47/12 , C12N7/00 , C12N2760/16051
Abstract: The invention concerns a bioreactor for production of virus and virus-like particles (VLPs), methods for production of virus and VLPs, methods for regulating the concentration of molecules inhibitory to viral and VLP yield in a cell culture chamber of a bioreactor, such as the extracapillary space of a hollow fiber bioreactor.
Abstract translation: 本发明涉及用于生产病毒和病毒样颗粒（VLP）的生物反应器，用于产生病毒和VLP的方法，用于在生物反应器的细胞培养室中调节抑制病毒和VLP产量的分子的浓度的方法，例如 中空纤维生物反应器的毛细血管空间。
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8.发明申请公开(公告)号：US20140024012A1
公开(公告)日：2014-01-23
申请号：US14033807
申请日：2013-09-23
Applicant: BIOVEST INTERNATIONAL, INC.
Inventor： DARRELL PAUL PAGE , ROBERT J. WOJCIECHOWSKI , MARTIN PEDER CREP
IPC: C12M1/34
CPC classification number: C12M41/40 , A61K35/12 , C12M23/26 , C12M23/28 , C12M23/34 , C12M23/44 , C12M23/58 , C12M25/10 , C12M27/00 , C12M29/00 , C12M29/10 , C12M29/18 , C12M33/14 , C12M41/20 , C12M41/26 , C12M41/34 , C12M41/38 , C12M41/48 , C12M47/04 , C12M47/10 , C12M47/12 , C12M47/20 , C12Q3/00 , F04B43/0072 , F04B43/09 , F04B43/12 , F04B43/1292
Abstract: An extra-capillary fluid cycling unit for maintaining and cycling fluid volumes in a cell culture chamber includes a housing and a first flexible reservoir extra-capillary fluid reservoir disposed in the housing. The extra-capillary fluid reservoir is in fluid communication with a cell culture chamber. A second flexible reservoir is also located in the housing, the second flexible reservoir being in fluid communication with a pressure source. A sensor plate is movably disposed in the housing between the extra-capillary reservoir and the second reservoir, wherein the second reservoir is pressurized to move the sensor plate in relation to the extra-capillary reservoir to cause fluid cycling and maintain fluid volumes in the cell growth chamber.
Abstract translation: 用于在细胞培养室中维持和循环流体体积的毛细血管外流体循环单元包括壳体和布置在壳体中的第一柔性储存器毛细管外液体储存器。 毛细血管外液体储存器与细胞培养室流体连通。 第二柔性储存器也位于壳体中，第二柔性储存器与压力源流体连通。 传感器板可移动地设置在毛细管外储存器和第二储存器之间的壳体中，其中第二储存器被加压以相对于毛细血管外储存器移动传感器板，以引起流体循环并保持细胞中的流体体积 生长室。
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