公开(公告)号：US20160362652A1

公开(公告)日：2016-12-15

申请号：US15245524

申请日：2016-08-24

Applicant: BIOVEST INTERNATIONAL, INC.

Inventor： DARRELL PAUL PAGE ,  ROBERT J. WOJCIECHOWSKI ,  MARTIN PEDER CREP

IPC: C12M1/02 ,  C12M1/34 ,  F04B43/09 ,  C12Q3/00 ,  F04B43/12 ,  F04B43/00 ,  C12M1/00 ,  C12M1/12

Abstract: An extra-capillary fluid cycling unit for maintaining and cycling fluid volumes in a cell culture chamber includes a housing and a first flexible reservoir extra-capillary fluid reservoir disposed in the housing. The extra-capillary fluid reservoir is in fluid communication with a cell culture chamber. A second flexible reservoir is also located in the housing, the second flexible reservoir being in fluid communication with a pressure source. A sensor plate is movably disposed in the housing between the extra-capillary reservoir and the second reservoir, wherein the second reservoir is pressurized to move the sensor plate in relation to the extra-capillary reservoir to cause fluid cycling and maintain fluid volumes in the cell growth chamber.

公开(公告)号：US20140024012A1

公开(公告)日：2014-01-23

申请号：US14033807

申请日：2013-09-23

Applicant: BIOVEST INTERNATIONAL, INC.

Inventor： DARRELL PAUL PAGE ,  ROBERT J. WOJCIECHOWSKI ,  MARTIN PEDER CREP

IPC: C12M1/34

CPC classification number: C12M41/40 ,  A61K35/12 ,  C12M23/26 ,  C12M23/28 ,  C12M23/34 ,  C12M23/44 ,  C12M23/58 ,  C12M25/10 ,  C12M27/00 ,  C12M29/00 ,  C12M29/10 ,  C12M29/18 ,  C12M33/14 ,  C12M41/20 ,  C12M41/26 ,  C12M41/34 ,  C12M41/38 ,  C12M41/48 ,  C12M47/04 ,  C12M47/10 ,  C12M47/12 ,  C12M47/20 ,  C12Q3/00 ,  F04B43/0072 ,  F04B43/09 ,  F04B43/12 ,  F04B43/1292

Abstract: An extra-capillary fluid cycling unit for maintaining and cycling fluid volumes in a cell culture chamber includes a housing and a first flexible reservoir extra-capillary fluid reservoir disposed in the housing. The extra-capillary fluid reservoir is in fluid communication with a cell culture chamber. A second flexible reservoir is also located in the housing, the second flexible reservoir being in fluid communication with a pressure source. A sensor plate is movably disposed in the housing between the extra-capillary reservoir and the second reservoir, wherein the second reservoir is pressurized to move the sensor plate in relation to the extra-capillary reservoir to cause fluid cycling and maintain fluid volumes in the cell growth chamber.

Abstract translation: 用于在细胞培养室中维持和循环流体体积的毛细血管外流体循环单元包括壳体和布置在壳体中的第一柔性储存器毛细管外液体储存器。 毛细血管外液体储存器与细胞培养室流体连通。 第二柔性储存器也位于壳体中，第二柔性储存器与压力源流体连通。 传感器板可移动地设置在毛细管外储存器和第二储存器之间的壳体中，其中第二储存器被加压以相对于毛细血管外储存器移动传感器板，以引起流体循环并保持细胞中的流体体积 生长室。