公开(公告)号：US20220251628A1

公开(公告)日：2022-08-11

申请号：US17679310

申请日：2022-02-24

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Michael L. SAMUELS ,  Jeffrey Charles OLSON ,  Andrew WATSON ,  Keith BROWN ,  Darren R. LINK

IPC: C12Q1/6806 ,  C40B50/08 ,  C12Q1/6874 ,  G01N33/543 ,  G01N33/58 ,  C12Q1/6804 ,  C12N15/10

Abstract: The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.

公开(公告)号：US20230219043A1

公开(公告)日：2023-07-13

申请号：US18178965

申请日：2023-03-06

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： Darren Roy LINK ,  John Brian HUTCHISON ,  Michael L. SAMUELS ,  Michael WEINER

IPC: B01F23/41 ,  C40B50/08 ,  G01N33/50 ,  C40B40/04 ,  B01J19/00 ,  B01F25/433 ,  G01N15/14 ,  B01L3/00 ,  B01F33/3011 ,  B01L7/00 ,  B01F101/23 ,  G01N15/10

CPC classification number: B01F23/41 ,  C40B50/08 ,  G01N33/5008 ,  C40B40/04 ,  B01J19/0046 ,  B01F25/433 ,  G01N15/1459 ,  B01L3/502761 ,  B01F33/3011 ,  B01F25/4336 ,  B01L2400/0487 ,  B01L2300/0654 ,  B01J2219/00286 ,  B01J2219/00479 ,  B01L7/52 ,  B01L2300/0636 ,  B01J2219/0059 ,  B01J2219/00702 ,  B01L2200/027 ,  B01J2219/00599 ,  B01F2101/23 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00592 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01L2300/0864 ,  B01L2400/0415 ,  G01N2500/00 ,  B01J2219/00743 ,  B01J2219/0074 ,  B01L2300/0645 ,  B01J2219/00657 ,  B01J2219/00418 ,  B01J2219/00351 ,  B01L2300/0867 ,  B01J2219/0065 ,  B01L2300/0681 ,  G01N2015/1006 ,  B01J2219/00664 ,  Y02A90/10

Abstract: The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.