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341 条记录 (耗时 0.04 秒)

    Protein that enhances expression of potassium channels on cell surfaces and nucleic acids that encode the same
    1.
    发明授权
    Protein that enhances expression of potassium channels on cell surfaces and nucleic acids that encode the same 有权

    公开(公告)号：US07060794B2

    公开(公告)日：2006-06-13

    申请号：US10075074

    申请日：2002-02-13

    申请人： Arthur M Brown ,  Barbara A Wible ,  Qing Yang

    发明人： Arthur M Brown ,  Barbara A Wible ,  Qing Yang

    IPC分类号： C07K14/00

    CPC分类号： C07K14/705 ,  C07K14/47 ,  C12Q1/6876

    摘要： The present invention provides polynucleotides that encode a protein, designated herein as K+ Channel Associated Protein or “KChAP”. It has been determined that expressing polynucleotides that encode KChAP in host cells, along with polynucleotides that encode the Kvα channel subunit Kv 2.1, the Kvα channel subunit Kv 2.2, the Kvα channel subunit Kv 1.3, or the Kvα channel subunit Kv 4.3, increases the number of Kv2.1, Kv 2.2, Kv1.3 or Kv4.3 channels, respectively, in the plasma membrane of such cells. The present invention also relates to a method of making cells that have increased numbers of Kv channels on the plasma membranes thereof and to a method of using such cells as model systems for studying the effect of pharmacological agents on Kv channels, particularly on Kv2.1, Kv 2.2, Kv 1.3, and Kv 4.3 channels. The present invention also relates to the protein KChAP.

    Protein that enhances expression of potassium channels on cell surfaces and nucleic acids that encode the same
    2.
    发明授权
    Protein that enhances expression of potassium channels on cell surfaces and nucleic acids that encode the same 失效
    增强细胞表面上钾通道表达的蛋白质和编码其的核酸

    公开(公告)号：US06207422B1

    公开(公告)日：2001-03-27

    申请号：US09062440

    申请日：1998-04-17

    申请人： Arthur M. Brown ,  Barbara A. Wible ,  Qing Yang

    发明人： Arthur M. Brown ,  Barbara A. Wible ,  Qing Yang

    IPC分类号： C12P1934

    CPC分类号： C07K14/705 ,  C07K14/47 ,  C12Q1/6876

    摘要： The present invention provides polynucleotides that encode a protein, designated herein as K+ Channel Associated Protein or “KChAP”. It has been determined that expressing polynucleotides that encode KChAP in host cells, along with polynucleotides that encode the Kv&agr; channel subunit Kv 2.1, the Kv&agr; channel subunit Kv 2.2, the Kv&agr; channel subunit Kv 1.3, or the Kv&agr; channel subunit Kv 4.3, increases the number of Kv2.1, Kv 2.2, Kv1.3 or Kv4.3 channels, respectively, in the plasma membrane of such cells. The present invention also relates to a method of making cells that have increased numbers of Kv channels on the plasma membranes thereof and to a method of using such cells as model systems for studying the effect of pharmacological agents on Kv channels, particularly on Kv2.1, Kv 2.2, Kv 1.3, and Kv 4.3 channels. The present invention also relates to the protein KChAP.

    摘要翻译： 本发明提供编码本文称为K +通道相关蛋白或“KChAP”的蛋白质的多核苷酸。 已经确定，表达编码宿主细胞中的KChAP的多核苷酸以及编码Kvalpha通道亚基Kv2.1，Kvalpha通道亚基Kv 2.2，Kvalpha通道亚基Kv 1.3或Kvalpha通道亚基Kv 4.3的多核苷酸增加了 Kv2.1，Kv 2.2，Kv1.3或Kv4.3通道的数量分别在这些细胞的质膜中。 本发明还涉及一种制备在其质膜上具有增加的Kv通道数目的细胞的方法，以及使用这种细胞作为模型系统的方法，用于研究药理剂对Kv通道的影响，特别是Kv2.1 ，Kv 2.2，Kv 1.3和Kv 4.3通道。 本发明还涉及蛋白质KChAP。

    Protein that enhances expression of potassium channels on cell surfaces and nucleic acids that encode the same
    3.
    发明授权
    Protein that enhances expression of potassium channels on cell surfaces and nucleic acids that encode the same 有权
    增强细胞表面上钾通道表达的蛋白质和编码其的核酸

    公开(公告)号：US06391561B1

    公开(公告)日：2002-05-21

    申请号：US09712495

    申请日：2000-11-14

    申请人： Arthur M. Brown ,  Barbara A. Wible ,  Qing Yang

    发明人： Arthur M. Brown ,  Barbara A. Wible ,  Qing Yang

    IPC分类号： C12Q168

    CPC分类号： C07K14/705 ,  C07K14/47 ,  C12Q1/6876

    摘要： The present invention provides polynucleotides that encode a protein, designated herein as K+ Channel Associated Protein or “KChAP”. It has been determined that expressing polynucleotides that encode KChAP in host cells, along with polynucleotides that encode the Kv&agr; channel subunit Kv 2.1, the Kv&agr; channel subunit Kv 2.2, the Kv&agr; channel subunit Kv 1.3, or the Kv&agr; channel subunit Kv 4.3, increases the number of Kv2.1, Kv 2.2, Kv1.3 or Kv4.3 channels, respectively, in the plasma membrane of such cells. The present invention also relates to a method of making cells that have increased numbers of Kv channels on the plasma membranes thereof and to a method of using such cells as model systems for studying the effect of pharmacological agents on Kv channels, particularly on Kv2.1, Kv 2.2, Kv 1.3, and Kv 4.3 channels. The present invention also relates to the protein KChAP.

    摘要翻译： 本发明提供编码本文称为K +通道相关蛋白或“KChAP”的蛋白质的多核苷酸。 已经确定表达编码宿主细胞中的KChAP的多核苷酸以及编码Kvalpha通道亚基Kv2.1，Kvalpha通道亚基Kv 2.2，Kvalpha通道亚基Kv 1.3或Kvalpha通道亚基Kv 4.3的多核苷酸增加了 Kv2.1，Kv 2.2，Kv1.3或Kv4.3通道的数量分别在这些细胞的质膜中。 本发明还涉及一种制备在其质膜上具有增加的Kv通道数目的细胞的方法，以及使用这种细胞作为模型系统的方法，用于研究药理剂对Kv通道的影响，特别是Kv2.1 ，Kv 2.2，Kv 1.3和Kv 4.3通道。 本发明还涉及蛋白质KChAP。

    Polymer compositions having improved barrier properties
    5.
    发明授权
    Polymer compositions having improved barrier properties 有权
    聚合物组合物具有改善的阻隔性能

    公开(公告)号：US09284391B2

    公开(公告)日：2016-03-15

    申请号：US13306321

    申请日：2011-11-29

    申请人： Mark L. Hlavinka ,  Qing Yang ,  Guylaine St. Jean ,  Brooke A. Gill ,  Deloris R. Gagan

    发明人： Mark L. Hlavinka ,  Qing Yang ,  Guylaine St. Jean ,  Brooke A. Gill ,  Deloris R. Gagan

    IPC分类号： C08F10/02 ,  C08F110/02 ,  C08F4/64 ,  C08F4/659 ,  C08F4/6592

    CPC分类号： C08F110/02 ,  C08F4/65912 ,  C08F4/65916 ,  C08F4/65925 ,  C08F4/65927 ,  C08F10/02 ,  Y10T428/1352 ,  C08F4/65904 ,  C08F2500/07 ,  C08F2500/12

    摘要： A polymer having a melt index of from about 0.5 g/10 min to about 4.0 g/10 min and a density of equal to or greater than 0.96 g/cc which when formed into a 1-mil film displays a moisture vapor transmission rate ranging from equal to or greater than about 0 to equal to or about 20% greater than X where X=k1{−61.95377+39.52785(Mz/Mw)−8.16974(Mz/Mw)2+0.55114(Mz/Mw)3}+k2{−114.01555(τ)+37.68575(Mz/Mw)(τ)−2.89177(Mz/Mw)2(τ)}+k3{120.37572(τ)2−25.91177(Mz/Mw)(τ)2}+k4{18.03254(τ)3} when Mw is from about 100 kg/mol to about 180 kg/moL; Mz is from about 300 kg/mol to about 1000 kg/mol; τ is from about 0.01 S to about 0.35 s; k1 is 1 g/100 in2·day; k2 is 1 g/100 in2·day·s; k3 is 1 g/100 in2·day·s2; and k4 is 1 g/100 in2·day·s3.

    摘要翻译： 熔体指数为约0.5g / 10min至约4.0g / 10min，密度等于或大于0.96g / cc的聚合物，当其形成1密耳膜时，其表现出一定范围内的湿气透过率 等于或大于X大于等于或大约20％，其中X = k1 {-61.95377 + 39.52785（Mz / Mw）-8.16974（Mz / Mw）2 + 0.55114（Mz / Mw）3} + k2 {-114.01555（τ）+37.68575（Mz / Mw）（τ）-2.89177（Mz / Mw）2（τ）} + k3 {120.37572（τ）2-25.91177（Mz / Mw）（τ） 当Mw为约100kg / mol至约180kg / moL时，k4 {18.03254（τ）3} Mz为约300kg / mol至约1000kg / mol; τ为约0.01S至约0.35s; k1为1 g / 100 in2·day; k2为1 g / 100 in2·day·s; k3为1 g / 100 in2·day·s2; k4为1 g / 100 in2·day·s3。

    Liquid film moving over porous catcher surface
    6.
    发明授权
    Liquid film moving over porous catcher surface 有权
    液膜移过多孔捕集器表面

    公开(公告)号：US09174438B2

    公开(公告)日：2015-11-03

    申请号：US12843910

    申请日：2010-07-27

    申请人： Yonglin Xie ,  Qing Yang ,  Roger S. Kerr ,  Chang-Fang Hsu

    发明人： Yonglin Xie ,  Qing Yang ,  Roger S. Kerr ,  Chang-Fang Hsu

    IPC分类号： B41J2/09 ,  B41J2/17 ,  B41J2/185

    CPC分类号： B41J2/09 ,  B41J2/1721 ,  B41J2/185

    摘要： A printhead includes a jetting module that forms liquid drops travelling along a first path. A deflection mechanism causes selected liquid drops formed by the jetting module to deviate from the first path and begin travelling along a second path. A catcher includes a stationary porous surface. A liquid film flows over the stationary porous surface of the catcher. The catcher is positioned relative to the first path such that the liquid drops travelling along one of the first path and the second path contact the liquid film.

    摘要翻译： 打印头包括形成沿着第一路径行进的液滴的喷射模块。 偏转机构使得由喷射模块形成的选定液滴偏离第一路径并开始沿第二路径行进。 捕手包括固定的多孔表面。 液膜在捕集器的固定多孔表面上流动。 捕获器相对于第一路径定位，使得沿着第一路径和第二路径中的一个行进的液体液体接触液体膜。

    CORRUGATED MEMBRANE MEMS ACTUATOR
    9.
    发明申请
    CORRUGATED MEMBRANE MEMS ACTUATOR 有权
    腐蚀膜MEMS致动器

    公开(公告)号：US20140022310A1

    公开(公告)日：2014-01-23

    申请号：US13552728

    申请日：2012-07-19

    申请人： Yonglin Xie ,  Qing Yang ,  James A. Katerberg

    发明人： Yonglin Xie ,  Qing Yang ,  James A. Katerberg

    IPC分类号： B41J2/05

    CPC分类号： B41J2/1404 ,  B41J2/14064 ,  B41J2/1412

    摘要： A liquid dispenser includes a first liquid chamber and a second liquid chamber. The first liquid chamber includes a nozzle. A heater is associated with the second liquid chamber. A flexible corrugated membrane is positioned to separate and fluidically seal the first liquid chamber and the second liquid chamber from each other.

    摘要翻译： 液体分配器包括第一液体室和第二液体室。 第一液体室包括喷嘴。 加热器与第二液体室相连。 柔性波纹膜被定位成将第一液体室和第二液体室彼此分离和流体密封。

    Liquid dispenser including curved vent
    10.
    发明授权
    Liquid dispenser including curved vent 有权
    液体分配器包括弯曲排气口

    公开(公告)号：US08573743B2

    公开(公告)日：2013-11-05

    申请号：US12911751

    申请日：2010-10-26

    申请人： Yonglin Xie ,  Carolyn R. Ellinger ,  Maria J. Lehmann ,  Joseph Jech, Jr. ,  Qing Yang

    发明人： Yonglin Xie ,  Carolyn R. Ellinger ,  Maria J. Lehmann ,  Joseph Jech, Jr. ,  Qing Yang

    IPC分类号： B41J2/16 ,  B41J2/18

    CPC分类号： B41J2/1404 ,  B41J2/1433 ,  B41J2002/14403 ,  B41J2202/12

    摘要： A liquid dispenser includes a liquid supply channel, a liquid return channel, and a liquid dispensing channel. The liquid dispensing channel includes a wall. The wall includes a surface. A portion of the wall defines an outlet opening. A drain is located in the wall downstream from the outlet opening. The drain includes a radius of curvature as viewed from a direction perpendicular to the wall. A liquid supply provides liquid that flows from the liquid supply channel through the liquid dispensing channel to the liquid return channel. A diverter member selectively diverts a portion of the flowing liquid through the outlet opening of the liquid dispensing channel.

    摘要翻译： 液体分配器包括液体供应通道，液体返回通道和液体分配通道。 液体分配通道包括壁。 墙壁包括一个表面。 壁的一部分限定出口开口。 排水口位于出口开口下游的墙壁中。 漏极包括从垂直于壁的方向观察的曲率半径。 液体供应液体从液体供应通道通过液体分配通道流到液体返回通道。 分流器构件选择性地将流动的液体的一部分转过液体分配通道的出口。