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19 条记录 (耗时 0.016 秒)

    Methods for reducing the recurrence of cardiac arrhythmia
    1.
    发明授权
    Methods for reducing the recurrence of cardiac arrhythmia 失效
    降低心律失常复发的方法

    公开(公告)号：US08450325B2

    公开(公告)日：2013-05-28

    申请号：US13158791

    申请日：2011-06-13

    申请人： Arthur M. Brown ,  Naresh Chand

    发明人： Arthur M. Brown ,  Naresh Chand

    IPC分类号： A61K31/4965

    CPC分类号： A61K31/495

    摘要： Disclosed are methods of preventing or treating cardiac arrhythmia comprising administering to a mammal in need thereof, such as a human, an effective amount of vanoxerine (GBR 12909) or a pharmaceutically acceptable salt, derivative or metabolite thereof.

    摘要翻译： 公开了预防或治疗心律失常的方法，其包括向有需要的哺乳动物（例如人）施用有效量的vanoxerine（GBR 12909）或其药学上可接受的盐，衍生物或代谢物。

    Protein that enhances expression of potassium channels on cell surfaces and nucleic acids that encode the same
    3.
    发明授权
    Protein that enhances expression of potassium channels on cell surfaces and nucleic acids that encode the same 失效
    增强细胞表面上钾通道表达的蛋白质和编码其的核酸

    公开(公告)号：US06207422B1

    公开(公告)日：2001-03-27

    申请号：US09062440

    申请日：1998-04-17

    申请人： Arthur M. Brown ,  Barbara A. Wible ,  Qing Yang

    发明人： Arthur M. Brown ,  Barbara A. Wible ,  Qing Yang

    IPC分类号： C12P1934

    CPC分类号： C07K14/705 ,  C07K14/47 ,  C12Q1/6876

    摘要： The present invention provides polynucleotides that encode a protein, designated herein as K+ Channel Associated Protein or “KChAP”. It has been determined that expressing polynucleotides that encode KChAP in host cells, along with polynucleotides that encode the Kv&agr; channel subunit Kv 2.1, the Kv&agr; channel subunit Kv 2.2, the Kv&agr; channel subunit Kv 1.3, or the Kv&agr; channel subunit Kv 4.3, increases the number of Kv2.1, Kv 2.2, Kv1.3 or Kv4.3 channels, respectively, in the plasma membrane of such cells. The present invention also relates to a method of making cells that have increased numbers of Kv channels on the plasma membranes thereof and to a method of using such cells as model systems for studying the effect of pharmacological agents on Kv channels, particularly on Kv2.1, Kv 2.2, Kv 1.3, and Kv 4.3 channels. The present invention also relates to the protein KChAP.

    摘要翻译： 本发明提供编码本文称为K +通道相关蛋白或“KChAP”的蛋白质的多核苷酸。 已经确定，表达编码宿主细胞中的KChAP的多核苷酸以及编码Kvalpha通道亚基Kv2.1，Kvalpha通道亚基Kv 2.2，Kvalpha通道亚基Kv 1.3或Kvalpha通道亚基Kv 4.3的多核苷酸增加了 Kv2.1，Kv 2.2，Kv1.3或Kv4.3通道的数量分别在这些细胞的质膜中。 本发明还涉及一种制备在其质膜上具有增加的Kv通道数目的细胞的方法，以及使用这种细胞作为模型系统的方法，用于研究药理剂对Kv通道的影响，特别是Kv2.1 ，Kv 2.2，Kv 1.3和Kv 4.3通道。 本发明还涉及蛋白质KChAP。

    Treatment for cardiac arrhythmias
    4.
    发明授权
    Treatment for cardiac arrhythmias 失效
    心律失常治疗

    公开(公告)号：US5733889A

    公开(公告)日：1998-03-31

    申请号：US739382

    申请日：1996-10-29

    申请人： Arthur M. Brown

    发明人： Arthur M. Brown

    IPC分类号： A61K31/70

    CPC分类号： A61K31/7076

    摘要： The present invention provides a novel treatment for cardiac arrhythmias, by administering S-adenosyl methionine decarboxylase inhibitors, preferably 5'-({(Z)-4-amino-2-butenyl}methylamino)-5'-deoxyadenosine. It has been discovered that 5'-({(Z)-4-amino-2-butenyl}methylamino)-5'-deoxyadenosine, increases the P--R interval, increases outward current through inward rectifier K.sup.+ channels and increases the hyperpolarization, of cardiac cells, thereby reducing cardiac excitability. Specifically, the method involves providing an S-adenosyl methionine decarboxylase inhibitor; combining the S-adenosyl methionine decarboxylase inhibitor with a pharmaceutically acceptable carrier to provide a pharmaceutical composition; administering an effective amount of the pharmaceutical composition to a patient suffering from a cardiac arrhythmia, wether such arrhythmias are induced by disease or cardiotoxicity. As a result of the treatment with S-adenosyl methionine decarboxylase inhibitor, spermine and spermidine levels are lowered in cardiac cells, the P--R interval is prolonged, cardiac excitability is reduced and the incidence of ventricular fibrillation, particularly sustained ventricular fibrillation is diminished. The method of the present invention is useful to terminate, prevent or reduce the incidence of cardiac arrhythmias, including, for example, ventricular tachycardia, atrial fibrillation ventricular fibrillation, particularly sustained ventricular fibrillation, and premature ventricular contractions.

    摘要翻译： 本发明通过施用5-腺苷甲硫氨酸脱羧酶抑制剂，优选5' - （（（（Z）-4-氨基-2-丁烯基}甲基氨基）-5'-脱氧腺苷来提供心律失常的新型治疗。 已经发现5' - （（（Z）-4-氨基-2-丁烯基}甲基氨基）-5'-脱氧腺苷增加PR间期，通过向内整流K +通道增加向外电流并增加心脏的超极化 细胞，从而降低心脏兴奋性。 具体地说，该方法包括提供S-腺苷甲硫氨酸脱羧酶抑制剂; 将S-腺苷甲硫氨酸脱羧酶抑制剂与药学上可接受的载体组合以提供药物组合物; 向患有心律失常的患者施用有效量的药物组合物，通过疾病或心脏毒性诱导更低的这种心律失常。 作为S-腺苷甲硫氨酸脱羧酶抑制剂治疗的结果，心脏细胞中精胺和亚精胺水平降低，P-R间期延长，心脏兴奋性降低，心室颤动，特别是持续性心室颤动的发生率降低。 本发明的方法可用于终止，预防或减少心律失常的发生，包括例如室性心动过速，心房颤动，特别是持续心室颤动，以及室性早搏。

    Suction electrode for intracellular potential measurement
    5.
    发明授权
    Suction electrode for intracellular potential measurement 失效
    用于细胞内电位测量的吸引电极

    公开(公告)号：US4128456A

    公开(公告)日：1978-12-05

    申请号：US840826

    申请日：1977-10-11

    申请人： Kai S. Lee ,  Norio Akaike ,  Arthur M. Brown

    发明人： Kai S. Lee ,  Norio Akaike ,  Arthur M. Brown

    IPC分类号： G01N27/30 ,  G01N33/487 ,  C12K1/10

    CPC分类号： G01N33/48728 ,  Y10S435/817

    摘要： An electrical sensing and stimulation electrode small enough to record intracellular activity within a single living cell. The electrode incorporates a cylindrical chamber with a finely tapered end section. The chamber is evacuated to hold the cell at its tip. Contained within the chamber are piping, circuitry, and controls to provide selected life support environment, stimulation, and continuous sensing of the iternal ionic composition of the captured cell.

    摘要翻译： 电传感和刺激电极足够小以记录单个活细胞内的细胞内活动。 电极包括具有细微锥形端部的圆柱形腔室。 将腔室抽出以将细胞保持在其尖端。 包含在室内的是管道，电路和控制装置，以提供所选择的生命支持环境，刺激和连续感测捕获的细胞的本征离子组成。

    Methods for preventing or treating cardiac arrhythmia
    7.
    发明申请
    Methods for preventing or treating cardiac arrhythmia 审中-公开
    预防或治疗心律失常的方法

    公开(公告)号：US20100069403A1

    公开(公告)日：2010-03-18

    申请号：US12591180

    申请日：2009-11-12

    申请人： Arthur M. Brown ,  Naresh Chand

    发明人： Arthur M. Brown ,  Naresh Chand

    IPC分类号： A61K31/4965 ,  A61P9/06

    CPC分类号： A61K31/495

    摘要： Disclosed are methods of preventing or treating cardiac arrhythmia comprising administering to a mammal in need thereof, such as a human, an effective amount of vanoxerine (GBR 12909) or a pharmaceutically acceptable salt, derivative or metabolite thereof.

    摘要翻译： 公开了预防或治疗心律失常的方法，其包括向有需要的哺乳动物（例如人）施用有效量的vanoxerine（GBR 12909）或其药学上可接受的盐，衍生物或代谢物。

    Pharmaceutical compositions for terminating acute episodes of cardiac arrhythmia, restoring sinus rhythm, preventing recurrence of cardiac arrhythmia and/or maintaining normal sinus rhythm in mammals
    9.
    发明申请
    Pharmaceutical compositions for terminating acute episodes of cardiac arrhythmia, restoring sinus rhythm, preventing recurrence of cardiac arrhythmia and/or maintaining normal sinus rhythm in mammals 审中-公开
    用于终止心律失常急性发作，恢复窦性心律，预防心律失常复发和/或维持哺乳动物正常窦性心律的药物组合物

    公开(公告)号：US20120028992A1

    公开(公告)日：2012-02-02

    申请号：US12805460

    申请日：2010-08-02

    申请人： Arthur M. Brown

    发明人： Arthur M. Brown

    IPC分类号： A61K31/495 ,  A61P9/06

    CPC分类号： A61K31/495 ,  A61K2300/00

    摘要： Disclosed are pharmaceutical compositions for and methods of preventing or treating acute and/or chronic cardiac arrhythmias in a mammal, including terminating acute episodes of cardiac arrhythmia, restoring normal sinus rhythm, preventing recurrence of cardiac arrhythmia and/or maintaining normal sinus rhythm, which contain a combination of 1-[2-[(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine.

    摘要翻译： 公开了用于预防或治疗哺乳动物急性和/或慢性心律失常的药物组合物和方法，包括终止心律失常的急性发作，恢复正常窦性心律，预防心律失常复发和/或维持正常窦性心律，其含有 1- [2 - [（4-氟苯基）甲氧基]乙基] -4-（3-苯基丙基）哌嗪与1- [2- [双（4-氟苯基）甲氧基]乙基] -4-（3- 苯基丙基）哌嗪。