公开(公告)号：US20120225818A1

公开(公告)日：2012-09-06

申请号：US13389215

申请日：2010-08-05

申请人： Shintaro Kamei ,  Asami Shindome ,  Takayoshi Hamamoto ,  Hiroaki Maeda ,  Masaki Hirashima ,  Sachio Okuda ,  Misako Umehashi ,  Sachie Ogawa ,  Megumi Imuta ,  Norio Akaike ,  Kazuo Takahama ,  Ryoko Wada

发明人： Shintaro Kamei ,  Asami Shindome ,  Takayoshi Hamamoto ,  Hiroaki Maeda ,  Masaki Hirashima ,  Sachio Okuda ,  Misako Umehashi ,  Sachie Ogawa ,  Megumi Imuta ,  Norio Akaike ,  Kazuo Takahama ,  Ryoko Wada

IPC分类号： A61K38/36 ,  A61P11/14

CPC分类号： C12N9/6443 ,  A61K38/4846

摘要： The activated Factor XI is provided as an antitussive for cough caused by the stimulation at the tracheal bifurcation such as chronic cough. A pharmaceutical composition for prevention, treatment and/or symptom amelioration of cough, comprising a polypeptide chain as an active ingredient and a pharmaceutically acceptable carrier, wherein the polypeptide chain consists of a full length amino acid sequence constituting activated Factor XI (hereinafter also referred to as “FXIa”), the amino acid sequence with one or several amino acids therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences.

摘要翻译： 提供活化因子XI作为由气管分叉如慢性咳嗽引起的咳嗽的镇咳药。 一种用于预防，治疗和/或症状改善咳嗽的药物组合物，其包含多肽链作为活性成分和药学上可接受的载体，其中所述多肽链由构成活化因子XI的全长氨基酸序列组成（以下也称为 作为“FXIa”），其中具有一个或几个氨基酸的氨基酸序列被缺失，取代或加入，或任一上述氨基酸序列的部分序列，或包含上述任何一种的氨基酸序列 氨基酸序列。

公开(公告)号：US4128456A

公开(公告)日：1978-12-05

申请号：US840826

申请日：1977-10-11

申请人： Kai S. Lee ,  Norio Akaike ,  Arthur M. Brown

发明人： Kai S. Lee ,  Norio Akaike ,  Arthur M. Brown

IPC分类号： G01N27/30 ,  G01N33/487 ,  C12K1/10

CPC分类号： G01N33/48728 ,  Y10S435/817

摘要： An electrical sensing and stimulation electrode small enough to record intracellular activity within a single living cell. The electrode incorporates a cylindrical chamber with a finely tapered end section. The chamber is evacuated to hold the cell at its tip. Contained within the chamber are piping, circuitry, and controls to provide selected life support environment, stimulation, and continuous sensing of the iternal ionic composition of the captured cell.

摘要翻译： 电传感和刺激电极足够小以记录单个活细胞内的细胞内活动。 电极包括具有细微锥形端部的圆柱形腔室。 将腔室抽出以将细胞保持在其尖端。 包含在室内的是管道，电路和控制装置，以提供所选择的生命支持环境，刺激和连续感测捕获的细胞的本征离子组成。

公开(公告)号：US20130224179A1

公开(公告)日：2013-08-29

申请号：US13845643

申请日：2013-03-18

申请人： SHINTARO KAMEI ,  ASAMI SHINDOME ,  TAKAYOSHI HAMAMOTO ,  HIROAKI MAEDA ,  MASAKI HIRASHIMA ,  SACHIO OKUDA ,  MISAKO UMEHASHI ,  SACHIE OGAWA ,  MEGUMI IMUTA ,  NORIO AKAIKE ,  KAZUO TAKAHAMA ,  RYOKO WADA

发明人： SHINTARO KAMEI ,  ASAMI SHINDOME ,  TAKAYOSHI HAMAMOTO ,  HIROAKI MAEDA ,  MASAKI HIRASHIMA ,  SACHIO OKUDA ,  MISAKO UMEHASHI ,  SACHIE OGAWA ,  MEGUMI IMUTA ,  NORIO AKAIKE ,  KAZUO TAKAHAMA ,  RYOKO WADA

IPC分类号： C12N9/64

CPC分类号： C12N9/6443 ,  A61K38/4846

摘要： The activated Factor XI is provided as an antitussive for cough caused by the stimulation at the tracheal bifurcation such as chronic cough. A pharmaceutical composition for prevention, treatment and/or symptom amelioration of cough, comprising a polypeptide chain as an active ingredient and a pharmaceutically acceptable carrier, wherein the polypeptide chain consists of a full length amino acid sequence constituting activated Factor XI (hereinafter also referred to as “FXIa”), the amino acid sequence with one or several amino acids therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences.

摘要翻译： 提供活化因子XI作为由气管分叉如慢性咳嗽引起的咳嗽的镇咳药。 一种用于预防，治疗和/或症状改善咳嗽的药物组合物，其包含多肽链作为活性成分和药学上可接受的载体，其中所述多肽链由构成活化因子XI的全长氨基酸序列组成（以下也称为 作为“FXIa”），其中具有一个或几个氨基酸的氨基酸序列被缺失，取代或加入，或任一上述氨基酸序列的部分序列，或包含上述任何一种的氨基酸序列 氨基酸序列。