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    Method of synthesis of β-thiolato cobalamin compounds
    5.
    发明授权
    Method of synthesis of β-thiolato cobalamin compounds 失效
    β-硫醇钴钴胺化合物的合成方法

    公开(公告)号：US07030105B2

    公开(公告)日：2006-04-18

    申请号：US10430468

    申请日：2003-05-06

    申请人： Nicola E. Brasch ,  Ling Xia

    发明人： Nicola E. Brasch ,  Ling Xia

    IPC分类号： A61K31/40 ,  A61K31/155 ,  A61B5/055 ,  A61B10/00 ,  C07B47/00

    CPC分类号： C07H23/00

    摘要： The invention provides a method for preparing glutathionylcobalamin (GluSCbl) which involves running the reaction in an aqueous solvent with a relatively small excess of glutathione, i.e. GluSH, specifically from one to less than four molar equivalents of GluSH. The formed GluSCbl is precipitated from the aqueous solvent, preferably by the addition of a precipitate inducing solvent. This provides GluSCbl in acceptable purity without the need for an additional chromatographic purification step. Additionally, it has been found that the reaction can be run to an acceptable level of purity by using very high concentrations of the reactants, i.e. around saturation concentrations for aquocobalamin. This has the advantage of eliminating the need for air-free conditions.

    摘要翻译： 本发明提供了一种制备谷胱甘肽钴胺素（GluSCbl）的方法，其包括在具有相对小量过量谷胱甘肽（即GluSH），特别是1至小于4摩尔当量的GluSH的水性溶剂中进行反应。 形成的GluSCb1从水性溶剂中沉淀出来，优选通过加入沉淀引发溶剂。 这提供了可接受纯度的GluSCbl，而不需要额外的色谱纯化步骤。 此外，已经发现，通过使用非常高浓度的反应物，即水溶胆固醇的饱和浓度，反应可以达到可接受的纯度水平。 这具有消除对无空气条件的需要的优点。

    Buckle
    6.
    外观设计
    Buckle 有权

    公开(公告)号：USD1000252S1

    公开(公告)日：2023-10-03

    申请号：US29798238

    申请日：2021-07-07

    申请人： Ling Xia

    设计人： Ling Xia

    摘要： FIG. 1 is a perspective view of a buckle showing my new design;
    FIG. 2 is another perspective view thereof;
    FIG. 3 is a front elevational view thereof;
    FIG. 4 is a rear elevational view thereof;
    FIG. 5 is a left side elevational view thereof;
    FIG. 6 is a right side elevational view thereof;
    FIG. 7 is a top plan view thereof; and,
    FIG. 8 is a bottom plan view thereof.
    The broken lines in the drawings depict portions of the buckle that form no part of the claimed design.