发明申请
- 专利标题： Anti-inflammatory nitro- and thia-fatty acids
- 专利标题（中）： 抗炎的硝基和硫脂肪酸
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申请号： US11072389申请日： 2005-03-04
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公开(公告)号： US20050176816A1公开(公告)日： 2005-08-11
- 发明人: Antonio Ferrante , Christopher Easton , Ling Xia
- 申请人： Antonio Ferrante , Christopher Easton , Ling Xia
- 优先权： AUPQ2914 19990917
- 主分类号： A61K8/30
- IPC分类号： A61K8/30 ; A61K8/36 ; A61K8/40 ; A61K8/46 ; A61K31/04 ; A61K31/10 ; A61K31/19 ; A61K31/20 ; A61K31/202 ; A61K31/21 ; A61K31/335 ; A61P1/04 ; A61P1/18 ; A61P3/10 ; A61P9/00 ; A61P9/10 ; A61P11/00 ; A61P11/02 ; A61P11/06 ; A61P17/00 ; A61P17/06 ; A61P25/00 ; A61P29/00 ; A61P31/00 ; A61P33/06 ; A61P35/00 ; A61P37/02 ; A61P37/06 ; A61P37/08 ; A61P39/06 ; A61P43/00 ; C07C17/16 ; C07C45/30 ; C07C205/02 ; C07C205/03 ; C07C205/14 ; C07C205/15 ; C07C205/50 ; C07C205/51 ; C07C317/44 ; C07C321/14 ; C07C321/18 ; C07C323/52 ; C07C409/40 ; A61K31/336 ; C07C23/04
摘要：
The present invention relates to compounds of the general formula: NO2-A-B wherein A is a saturated or unsaturated hydrocarbon chain of 14-26 carbon atoms and B is (CH2)n(COOH)m in which n is an integer from 0 to 2 and m is an integer from 0 to 2; or of general formula (I), wherein A′ is a saturated or unsaturated hydrocarbon chain of 9-26 carbon atoms, X is oxygen or is absent and B′ is (CH2)j(COOH)k in which j is an integer from 1 to 3 and k is 0 or 1; and the derivatives thereof in which the hydrocarbon chain includes one or more than one substitution selected from the group consisting of hydroxy, hydroperoxy, epoxy and peroxy. These compounds have biological activity, e.g. as anti-infective or anti-inflammatory agents.
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