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    Connector assembly having two connectors capable of movement in differing directions
    4.
    发明授权
    Connector assembly having two connectors capable of movement in differing directions 有权
    具有能够沿不同方向移动的两个连接器的连接器组件

    公开(公告)号：US08210861B2

    公开(公告)日：2012-07-03

    申请号：US12778822

    申请日：2010-05-12

    Applicant: William E. Tanis ,  Brian J. Williams ,  Paul Walter McDowell

    Inventor： William E. Tanis ,  Brian J. Williams ,  Paul Walter McDowell

    IPC: H01R13/64

    CPC classification number: H01R13/6315 ,  H01R13/743

    Abstract: A connector assembly including a first connector configured to be movably mounted to a support structure and having a first mating terminal. The first connector is movable with respect to the support structure in an axial direction along an alignment axis. The connector assembly also includes a second connector that is configured to be movably mounted to a support panel and has a second mating terminal. The second connector is movable with respect to the support panel in a radial direction relative to an alignment axis. The second connector shifts in the radial, direction to align the first and second mating terminals when the first and second connectors engage each other in a misaligned manner. The first connector moves between a projected position and a retracted position along the alignment axis to facilitate establishing a communication pathway between the first and second mating terminals.

    Abstract translation: 一种连接器组件，包括构造成可移动地安装到支撑结构并具有第一配合端子的第一连接器。 第一连接器可沿着对准轴在轴向上相对于支撑结构移动。 连接器组件还包括被配置为可移动地安装到支撑面板并具有第二配合端子的第二连接器。 第二连接器可相对于支撑板相对于对准轴在径向方向上移动。 当第一和第二连接器以不对准的方式彼此接合时，第二连接器在径向方向上移动以对准第一和第二配合端子。 第一连接器沿着对准轴线在突出位置和缩回位置之间移动，以便于建立第一和第二匹配端子之间的连通路径。

    Peptides useful as tachykinin agonists
    5.
    发明授权
    Peptides useful as tachykinin agonists 失效
    可用作速激肽激动剂的肽

    公开(公告)号：US5331089A

    公开(公告)日：1994-07-19

    申请号：US993493

    申请日：1992-12-17

    Applicant: Neil R. Curtis ,  Brian J. Williams

    Inventor： Neil R. Curtis ,  Brian J. Williams

    IPC: A61K38/00 ,  C07K7/22 ,  C07K7/54 ,  C07K7/06 ,  C07K7/08

    CPC classification number: C07K7/22 ,  A61K38/00

    Abstract: A class of monomeric or dimeric peptides containing a specific hexa- or heptapeptide unit in either linear or cyclic form are active tachykinin antagonists and are therefore useful in disease states in which these peptides have been implicated, such as allergic conditions, inflammation, migraine, arthritis and CNS disorders.

    Abstract translation: 含有线性或环状特异性六肽或七肽单元的一类单体或二聚体肽是活性速激肽拮抗剂，因此可用于涉及这些肽的疾病状态，如过敏性疾病，炎症，偏头痛，关节炎 和CNS疾病。

    3,3-diphenyl prop-2-yl amino acid derivatives and their use as tachykinin antagonists
    6.
    发明授权
    3,3-diphenyl prop-2-yl amino acid derivatives and their use as tachykinin antagonists 失效
    3,3-二苯基丙-2-基氨基酸衍生物及其作为速激肽拮抗剂的用途

    公开(公告)号：US5633281A

    公开(公告)日：1997-05-27

    申请号：US492067

    申请日：1995-12-08

    Applicant: Martin R. Teall ,  Brian J. Williams

    Inventor： Martin R. Teall ,  Brian J. Williams

    IPC: C07C229/14 ,  A61K31/195

    CPC classification number: C07C229/14

    Abstract: Compounds of formula (I), or a salt or prodrug thereof, wherein R.sup.1 represents H, C.sub.1-4 alkyl or CH.sub.2 COOH; R.sup.2 represents H or C.sub.1-4 alkyl, with the proviso that R.sup.1 and R.sup.2 are not both H; R.sup.3 and R.sup.4 each independently rely resent H, C.sub.1-, alkyl. C.sub.2-6 alkenyl C.sub.1-6 alkoxy, halo or trifluoromethyl; A.sup.1, A.sup.2, A.sup.3, and A.sup.4 each independently represent H, C.sub.1-6 alkyl, C.sub.1-6 alkenyl, C.sub.1-6 alkoxy, halo or trifluoromethyl; and A.sup.5 and A.sup.6 each independently represent H or C.sub.1-4 are tachykinin antagonists useful ##STR1##

    Abstract translation: PCT No.PCT / GB93 / 02592 Sec。 371 1995年12月8日第 102（e）日期1995年12月8日PCT 1993年12月17日PCT公布。 WO94 / 15903 PCT出版物 日期1994年7月21日式（I）化合物或其盐或前药，其中R 1表示H，C 1-4烷基或CH 2 COOH; R2表示H或C1-4烷基，条件是R1和R2不同时为H; R3和R4各自独立地依赖于H，C 1，烷基。 C 2-6烯基C 1-6烷氧基，卤素或三氟甲基; A1，A2，A3和A4各自独立地表示H，C1-6烷基，C1-6链烯基，C1-6烷氧基，卤素或三氟甲基; 和A5和A6各自独立地表示H或C1-4的速激肽拮抗剂。

    Azacyclic compounds compositions containing them and their use as tachykinin antagonists
    9.
    发明授权
    Azacyclic compounds compositions containing them and their use as tachykinin antagonists 失效
    含有它们的氮环化合物组合物及其作为速激肽拮抗剂的用途

    公开(公告)号：US5633266A

    公开(公告)日：1997-05-27

    申请号：US495429

    申请日：1995-07-26

    Applicant: Raymond Baker ,  Christopher J. Swain ,  Brian J. Williams

    Inventor： Raymond Baker ,  Christopher J. Swain ,  Brian J. Williams

    IPC: A61K31/4427 ,  A61K31/445 ,  A61K31/451 ,  A61P1/08 ,  A61P25/20 ,  A61P29/00 ,  A61P43/00 ,  C07D207/00 ,  C07D211/42 ,  C07D211/54 ,  C07D401/06

    CPC classification number: C07D401/06 ,  C07D211/42

    Abstract: The present invention relates to compounds of formula (I), and salts and prodrugs thereof, wherein n is 1 , 2 or 3 and where any carbon atom of (CH.sub.2).sub.n may be substituted by R.sup.4 and/or R.sup.5 ; X represents O or S; R.sup.1 represents optionally substituted (CH.sub.2).sub.q phenyl, wherein q is 0, 1, 2 or 3; R.sup.2 represents optionally substituted aryl, heteroaryl, benzhydryl or benzyl; R.sup.4 and R.sup.5 each independently represent H, halo, C.sub.1-6 alkyl, oxo, CO.sub.2 R.sup.a or CONR.sup.a R.sup.b ; R.sup.6 represents H or C.sub.1-6 alkyl; R.sup.7 represents C.sub.1-6 alkyl or optionally substituted phenyl; R.sup.8 represents H, COR.sup.a, CO.sub.2 R.sup.a, COCONR.sup.a R.sup.b, COCO.sub.2 R.sup.a, C.sub.1-6 alkyl optionally substituted by a variety of substituents, or C.sub.1-6 alkyl, optionally substituted by oxo, substituted by an optionally substituted aromatic heterocycle. The compounds are tachykinin antagonists useful for treating pain or inflammation, migraine or emesis.

    Abstract translation: PCT No.PCT / EP94 / 00412 Sec。 371日期：1995年7月26日 102（e）日期1995年7月26日PCT 1994年2月10日PCT PCT。 WO94 / 19323 PCT出版物 （I）的化合物本发明涉及式（I）化合物及其盐和前药，其中n为1,2或3，并且其中（CH 2）n的任何碳原子可以是 被R4和/或R5取代; X表示O或S; R 1表示任选取代的（CH 2）q苯基，其中q是0,1,2或3; R 2表示任选取代的芳基，杂芳基，二苯甲基或苄基; R 4和R 5各自独立地表示H，卤素，C 1-6烷基，氧代，CO 2 R a或CONR a R b; R 6表示H或C 1-6烷基; R 7表示C 1-6烷基或任选取代的苯基; R8表示H，CORa，CO 2 R a，COCONR a R b，COCO 2 R a，任选被各种取代基取代的C 1-6烷基，或任选被氧代取代的被任选取代的芳族杂环取代的C 1-6烷基。 这些化合物是可用于治疗疼痛或炎症，偏头痛或呕吐的速激肽拮抗剂。

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