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1.发明申请公开(公告)号：US20090275723A1
公开(公告)日：2009-11-05
申请号：US12503988
申请日：2009-07-16
Applicant: Alex Sergey Ionkin , Brian M. Fish , William Marshall
Inventor： Alex Sergey Ionkin , Brian M. Fish , William Marshall
CPC classification number: C08G18/24 , C08G18/222 , C08G18/4219
Abstract: Processes for making ivalent germanium and tin compounds are provided. The divalent germanium and tin compounds have been found to be efficient catalysts for the formation of polyurethanes.
Abstract translation: 提供了制备二价锗和锡化合物的方法。 已经发现二价锗和锡化合物是形成聚氨酯的有效催化剂。
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2.发明授权Stabilized divalent germanium and tin compounds, processes for making the compounds, and processes using the compounds 失效稳定的二价锗和锡化合物，制备该化合物的方法和使用该化合物的方法公开(公告)号：US07626049B2
公开(公告)日：2009-12-01
申请号：US11406994
申请日：2006-04-18
Applicant: Alex Sergey Ionkin , Brian M. Fish , William Marshall
Inventor： Alex Sergey Ionkin , Brian M. Fish , William Marshall
CPC classification number: C08G18/24 , C08G18/222 , C08G18/4219
Abstract: Divalent germanium and tin compounds are provided. The divalent germanium and tin compounds have been found to be efficient catalysts for the formation of polyurethanes. Methods for making polyurethanes using the catalysts are also provided.
Abstract translation: 提供了二价锗和锡化合物。 已经发现二价锗和锡化合物是形成聚氨酯的有效催化剂。 还提供了使用催化剂制备聚氨酯的方法。
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公开(公告)号：US09121402B2
公开(公告)日：2015-09-01
申请号：US13393620
申请日：2010-08-27
Applicant: William Marshall , Rod Shampine , Edward Leugemors , Hubertus V. Thomeer
Inventor： William Marshall , Rod Shampine , Edward Leugemors , Hubertus V. Thomeer
CPC classification number: F04B53/16 , F04B1/143 , F04B47/00 , Y10T29/49236 , Y10T29/49238
Abstract: A pump body is pre-compressed by expanding a displacement plug in a cavity to pre-compress a portion of a pump body comprising a piston bore, an inlet bore and an outlet bore spaced from said cavity, and connected in a pump assembly. A fluid pump assembly is made up of a plurality of pump bodies connected side by side between opposing end plates with a plurality of fasteners tightened to compress the pump bodies between the end plates, wherein each pump body comprises a piston bore, an inlet bore, an outlet bore and an expanded displacement plug in a cavity; and wherein the expanded displacement plug applies a pre-compressive force at the cavity on each of the pump bodies.
Abstract translation: 泵体通过将空腔中的置换塞膨胀以预压缩泵体的一部分来预压缩，该泵体包括活塞孔，入口孔和与所述空腔间隔开的出口孔，并连接在泵组件中。 流体泵组件由在相对的端板之间并排连接的多个泵体组成，多个紧固件被紧固以在端板之间压缩泵体，其中每个泵体包括活塞孔，入口孔， 空腔中的出口孔和膨胀的位移塞; 并且其中所述膨胀排量塞在每个所述泵体上的空腔处施加预压力。
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公开(公告)号：US08658785B1
公开(公告)日：2014-02-25
申请号：US13647869
申请日：2012-10-09
Applicant: Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read
Inventor： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
CPC classification number: C12N15/113 , C12N15/111 , C12N15/1135 , C12N2310/11 , C12N2310/14 , C12N2320/11 , G06F19/18
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.
Abstract translation: 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒。
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5.发明申请siRNA Targeting Cyclin-dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) 审中-公开siRNA靶向细胞周期蛋白依赖性激酶抑制剂1B（p27，Kip1）（CDKN1B）公开(公告)号：US20130225667A1
公开(公告)日：2013-08-29
申请号：US13867168
申请日：2013-04-22
Applicant: Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
Inventor： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC: C07H21/02
CPC classification number: C07H21/02 , A61K31/713 , C07H21/00 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12N2330/30 , C12Y304/21047 , G16B20/00
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for CDKN1B.
Abstract translation: 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对CDKN1B的核苷酸序列的那些。
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Patent Agency Ranking
6.发明授权公开(公告)号：US08247169B2
公开(公告)日：2012-08-21
申请号：US12660582
申请日：2010-03-01
Applicant: Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
Inventor： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
CPC classification number: C12N15/113 , C12N15/111 , C12N15/1135 , C12N2310/11 , C12N2310/14 , C12N2320/11 , G06F19/18
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for DGAT2.
Abstract translation: 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对DGAT2核苷酸序列的那些。
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公开(公告)号：US08198427B1
公开(公告)日：2012-06-12
申请号：US11980210
申请日：2007-10-30
Applicant: Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
Inventor： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
CPC classification number: A61K31/713 , C07K14/705 , C12N9/90 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/11 , C12Y304/21047 , C12Y502/01008 , G06F19/18
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for CTNNB1.
Abstract translation: 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对CTNNB1的核苷酸序列的那些。
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8.发明申请公开(公告)号：US20120052487A9
公开(公告)日：2012-03-01
申请号：US10940892
申请日：2004-09-14
Applicant: Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
Inventor： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
CPC classification number: C12Y113/12007 , A61K31/713 , C12N15/1048 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12Y502/01008 , G06F19/18
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.
Abstract translation: 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒。
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公开(公告)号：US20120015850A1
公开(公告)日：2012-01-19
申请号：US13199946
申请日：2011-09-13
Applicant: Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
Inventor： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
CPC classification number: C12N15/113 , C12N15/111 , C12N15/1135 , C12N2310/11 , C12N2310/14 , C12N2320/11 , G16B20/00
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for SOD1.
Abstract translation: 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对SOD1的核苷酸序列的那些。
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公开(公告)号：US20110319296A1
公开(公告)日：2011-12-29
申请号：US13136780
申请日：2011-08-10
Applicant: Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
Inventor： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
CPC classification number: C12N15/113 , C12N15/111 , C12N15/1135 , C12N2310/11 , C12N2310/14 , C12N2320/11 , G06F19/18
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.
Abstract translation: 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒。
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