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公开(公告)号：US06548657B1
公开(公告)日：2003-04-15
申请号：US09216584
申请日：1998-12-18
申请人： Alex Burgin , Leonid Beigelman , Laurent Bellon
发明人： Alex Burgin , Leonid Beigelman , Laurent Bellon
IPC分类号： C07M2102
CPC分类号： C12N15/113 , A61K38/00 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/3519 , C12Y204/02001 , C12Y207/01037 , C12N2310/3521
摘要： Nucleic acid catalysts, method of screening for variants of nucleic acid catalysts, synthesis of ribozyme libraries and discovery of gene sequences are described.
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公开(公告)号：US06280936B1
公开(公告)日：2001-08-28
申请号：US09094381
申请日：1998-06-09
申请人： Alex Burgin , Leonid Beigelman , Laurent Bellon
发明人： Alex Burgin , Leonid Beigelman , Laurent Bellon
IPC分类号： C12Q168
CPC分类号： C12N15/1135 , A61K38/00 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12Y204/02001 , C12Y207/01037 , C12N2310/3521
摘要： Nucleic acid catalysts, method of screening for variants of nucleic acid catalysts, synthesis of ribozyme libraries and discovery of gene sequences are described.
摘要翻译： 描述了核酸催化剂，核酸催化剂变体筛选方法，核酶文库的合成和基因序列的发现。
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公开(公告)号：US06528640B1
公开(公告)日：2003-03-04
申请号：US09474432
申请日：1999-12-29
申请人： Leonid Beigelman , Alex Burgin , Amber Beaudry , Alexander Karpeisky , Jasenka Matulic-Adamic , David Sweedler , Shawn Zinnen
发明人： Leonid Beigelman , Alex Burgin , Amber Beaudry , Alexander Karpeisky , Jasenka Matulic-Adamic , David Sweedler , Shawn Zinnen
IPC分类号： C07H2102
CPC分类号： C12N15/113 , A61K38/00 , C07H19/10 , C07H19/20 , C07H21/00 , C12N15/1131 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/18 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/332 , C12N2310/345 , C12N2310/346 , C12P19/30 , C12P19/305 , C12Y204/02001 , C12Y207/01037 , C12Y207/07049 , C12Y301/03048 , C12N2310/3523 , C12N2310/3521
摘要： Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. Also, described are the use of novel enzymatic nucleic acid molecules to inhibit HER2/neu/ErbB2 gene expression and their applications in human therapy.
摘要翻译： 公开了新型核苷酸三磷酸酯，合成方法和将这些核苷酸三磷酸引入寡核苷酸的方法，以及分离新型核酸催化剂（例如核酶）。 还描述了新型酶促核酸分子用于抑制HER2 / neu / ErbB2基因表达及其在人类治疗中的应用。
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公开(公告)号：US06482932B1
公开(公告)日：2002-11-19
申请号：US09301511
申请日：1999-04-28
申请人： Leonid Beigelman , Alex Burgin , Amber Beaudry , Alexander Karpeisky , Jasenka Matulic-Adamic , David Sweedler , Shawn Zinnen
发明人： Leonid Beigelman , Alex Burgin , Amber Beaudry , Alexander Karpeisky , Jasenka Matulic-Adamic , David Sweedler , Shawn Zinnen
IPC分类号： C07H2102
CPC分类号： C12N15/113 , A61K38/00 , C07H19/10 , C07H19/20 , C07H21/00 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/332 , C12N2310/345 , C12Y204/02001 , C12Y207/01037 , C12N2310/3521
摘要： Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed.
摘要翻译： 公开了新型核苷酸三磷酸酯，合成方法和将这些核苷酸三磷酸引入寡核苷酸的方法，以及分离新型核酸催化剂（例如核酶）。
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公开(公告)号：US06509460B1
公开(公告)日：2003-01-21
申请号：US09644966
申请日：2000-08-23
申请人： Leonid Beigelman , Alex Burgin , Amber Beaudry , Alexander Karpeisky , Jasenka Matulic-Adamic , David Sweedler
发明人： Leonid Beigelman , Alex Burgin , Amber Beaudry , Alexander Karpeisky , Jasenka Matulic-Adamic , David Sweedler
IPC分类号： C07H1910
CPC分类号： C12N15/113 , A61K38/00 , C07H19/10 , C07H19/20 , C07H21/00 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/332 , C12N2310/345 , C12Y204/02001 , C12Y207/01037 , C12N2310/3521
摘要： Novel nucleoside triphosphates, methods of synthesis and process of incorporating these nucleoside triphosphates into oligonucleotides are disclosed.
摘要翻译： 公开了新型核苷三磷酸盐，合成方法和将这些核苷三磷酸纳入寡核苷酸的方法。
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公开(公告)号：US6127535A
公开(公告)日：2000-10-03
申请号：US186675
申请日：1998-11-04
申请人： Leonid Beigelman , Alex Burgin , Amber Beaudry , Alexander Karpeisky , Jasenka Matulic-Adamic , David Sweedler
发明人： Leonid Beigelman , Alex Burgin , Amber Beaudry , Alexander Karpeisky , Jasenka Matulic-Adamic , David Sweedler
IPC分类号： A61K38/00 , C07H19/10 , C07H19/20 , C07H21/00 , C12N15/113
CPC分类号： C12N15/113 , C07H19/10 , C07H19/20 , C07H21/00 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12Y204/02001 , C12Y207/01037 , A61K38/00 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/332 , C12N2310/345
摘要： Novel nucleoside triphosphates, methods of synthesis and process of incorporating these nucleoside triphosphates into oligonucleotides are disclosed.
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公开(公告)号：US5672501A
公开(公告)日：1997-09-30
申请号：US541365
申请日：1995-10-05
IPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12N15/113 , C12N5/06 , C12N15/00 , C12P19/34
CPC分类号： C12N15/1137 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12N15/1138 , C12Y304/24017 , C12N2310/121 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/332 , C12N2310/346
摘要： An enzymatic nucleic acid having a modification selected from pyridin-4-one, pyridin-2-one, phenyl, pseudouracil, 2, 4, 6-trimethoxy benzene, 3-methyluracil, dihydrouracil, naphthyl, 6-methyl-uracil and aminophenyl.
摘要翻译： 具有选自吡啶-4-酮，吡啶-2-酮，苯基，假尿嘧啶，2,4,6-三甲氧基苯，3-甲基尿嘧啶，二氢尿嘧啶，萘基，6-甲基 - 尿嘧啶和氨基苯基的酶的核酸。
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公开(公告)号：US20050003502A1
公开(公告)日：2005-01-06
申请号：US09993245
申请日：2001-11-14
申请人： Alex Burgin , Kathyrn Hjerrild , Hidong Kim , Bart Staker , Lance Stewart , Craig Behnke , Michael Feese
发明人： Alex Burgin , Kathyrn Hjerrild , Hidong Kim , Bart Staker , Lance Stewart , Craig Behnke , Michael Feese
CPC分类号： C12N9/90 , C07K2299/00
摘要： This invention relates to crystalline structures of the topoisomerase I and their use in designing new anti-cancer agents anti-viral agents and anti-microbial agents.
摘要翻译： 本发明涉及拓扑异构酶I的结晶结构及其在设计新的抗癌剂抗病毒剂和抗微生物剂中的用途。
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9.发明授权Substituted benzoazole PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders 有权用于治疗炎症，心血管和CNS疾病的取代的苯扎唑PDE4抑制剂公开(公告)号：US08883833B2
公开(公告)日：2014-11-11
申请号：US12275165
申请日：2008-11-20
申请人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Vincent Sandanayaka , Alexander Kiselyov , Munagala Rao
发明人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Vincent Sandanayaka , Alexander Kiselyov , Munagala Rao
IPC分类号： C07D513/04 , C07D498/04 , C07D417/04 , C07D417/06 , C07D417/14 , C07D277/64 , C07D277/82 , C07D263/56 , C07D263/58 , A61K31/519 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/428 , A61K31/423
CPC分类号： C07D417/14 , A61K31/423 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , C07D263/56 , C07D263/58 , C07D277/64 , C07D277/82 , C07D417/04 , C07D417/06 , C07D498/04 , C07D513/04
摘要： The invention relates to substituted benzothiazoles, benzoxazoles—and their counterparts having pyridine and pyrimidine rings replacing the benzene ring—that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula I: in which A and B are carbocycles or heterocycles. A particular embodiment is
摘要翻译： 本发明涉及用于治疗中风，心肌梗塞和心血管炎症状况的可用于治疗中风，心肌梗死和心血管炎症状况的苯环的吡啶和嘧啶环的取代苯并唑和其对应物与包含这些化合物的药物组合物的方法， 治疗哺乳动物的中风，心肌梗死和心血管炎症状况。 化合物具有通式I：其中A和B是碳环或杂环。 一个特定的实施例是
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公开(公告)号：US08877816B2
公开(公告)日：2014-11-04
申请号：US12275168
申请日：2008-11-20
IPC分类号： A61K31/165 , C07C233/02 , A61P29/00 , C07C311/08 , C07C275/32 , C07C43/295 , C07D213/73 , C07C45/71 , C07C43/29 , C07C205/38 , C07D213/81 , C07D213/83
CPC分类号： C07D213/73 , C07C43/29 , C07C43/295 , C07C45/71 , C07C205/38 , C07C275/32 , C07C311/08 , C07D213/81 , C07D213/83 , C07C47/575
摘要： Compounds of the formula: are disclosed. The compounds act as phosphodiesterase-4 modulators, and useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions. Other embodiments are also disclosed.
摘要翻译： 公开了下式的化合物。 该化合物作为磷酸二酯酶-4调节剂，可用于治疗中风，心肌梗死和心血管炎症状况。 还公开了其他实施例。
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