公开(公告)号：US10761104B2

公开(公告)日：2020-09-01

申请号：US15593228

申请日：2017-05-11

Applicant: Agilent Technologies, Inc.

Inventor： Reid A. Brennen ,  Bo Curry ,  Joel Myerson ,  Paige Anderson ,  Arthur Schleifer ,  Rolfe Anderson

IPC: G01N35/00 ,  G01N35/10 ,  C12N15/10

Abstract: One or more liquids are transferred from a source array to one or more remotely positioned destination sites such as chambers by utilizing one or more movable transfer elements, such as contact pins or capillaries. The source array may include a predetermined organization of addresses at which materials are positioned. One or more materials may be selected for transfer. Based on the selection, one or more addresses may be accessed by the transfer element(s). The addresses may correspond to spots on a surface of the source array. Each spot may be a feature containing one or more (bio)chemical compounds. At the chamber(s), the material(s) may be processed, such by reaction with one or more reagents. The reaction(s) may entail synthesis of one or more desired products. Alternatively, reaction(s) may be performed at the source array, and the product(s) then transferred to the chamber(s).

公开(公告)号：US20170328928A1

公开(公告)日：2017-11-16

申请号：US15593228

申请日：2017-05-11

Applicant: Agilent Technologies, Inc.

Inventor： Reid A. Brennen ,  Bo Curry ,  Joel Myerson ,  Paige Anderson ,  Arthur Schleifer ,  Rolfe Anderson

IPC: G01N35/10 ,  G01N35/00 ,  C12N15/10

CPC classification number: G01N35/1074 ,  G01N35/1009 ,  G01N35/1065 ,  G01N2035/1037 ,  G01N2035/1039 ,  G01N2035/1044

Abstract: One or more liquids are transferred from a source array to one or more remotely positioned destination sites such as chambers by utilizing one or more movable transfer elements, such as contact pins or capillaries. The source array may include a predetermined organization of addresses at which materials are positioned. One or more materials may be selected for transfer. Based on the selection, one or more addresses may be accessed by the transfer element(s). The addresses may correspond to spots on a surface of the source array. Each spot may be a feature containing one or more (bio)chemical compounds. At the chamber(s), the material(s) may be processed, such by reaction with one or more reagents. The reaction(s) may entail synthesis of one or more desired products. Alternatively, reaction(s) may be performed at the source array, and the product(s) then transferred to the chamber(s).

公开(公告)号：US11077440B2

公开(公告)日：2021-08-03

申请号：US16460551

申请日：2019-07-02

Applicant: Agilent Technologies, Inc.

Inventor： Curt A. Flory ,  Dustin Chang ,  Pallevi Srivastva ,  Rolfe Anderson

IPC: B01L3/00

Abstract: The invention relates generally to methods and apparatus that gravitationally transfer cells from a first medium to a second medium. More specifically, the invention relates to a novel microfluidic device. The microfluidic device includes a cell transfer region, a cell settling channel, a waste channel, a cell output channel, and an input medium channel. The cell settling channel, the waste channel, and the cell output channel extend from, are in fluid communication with, and are smaller in cross section than the cell transfer region. The cell output channel is substantially perpendicular to the cell settling channel and to the waste channel. The input medium channel extends from and is in fluid communication with the cell output channel.

公开(公告)号：US20200023364A1

公开(公告)日：2020-01-23

申请号：US16460551

申请日：2019-07-02

Applicant: Agilent Technologies, Inc.

Inventor： Curt A. Flory ,  Dustin Chang ,  Pallevi Srivastva ,  Rolfe Anderson

IPC: B01L3/00

Abstract: The invention relates generally to methods and apparatus that gravitationally transfer cells from a first medium to a second medium. More specifically, the invention relates to a novel microfluidic device. The microfluidic device includes a cell transfer region, a cell settling channel, a waste channel, a cell output channel, and an input medium channel. The cell settling channel, the waste channel, and the cell output channel extend from, are in fluid communication with, and are smaller in cross section than the cell transfer region. The cell output channel is substantially perpendicular to the cell settling channel and to the waste channel. The input medium channel extends from and is in fluid communication with the cell output channel.

公开(公告)号：US20230236211A1

公开(公告)日：2023-07-27

申请号：US18001581

申请日：2021-06-11

Applicant: Agilent Technologies, Inc.

Inventor： Rolfe Anderson ,  Adrienne Mccampbell ,  Victor Lim ,  Carol T. Schembri ,  Michal Johannsen ,  Fleming Lassen Nielsen

IPC: G01N35/00 ,  G01N1/31 ,  G01N1/30

CPC classification number: G01N35/00029 ,  G01N1/312 ,  G01N1/30 ,  G01N2035/00079 ,  G01N2035/00138 ,  G01N2035/00089 ,  G01N2035/00346 ,  G01N2001/305 ,  G01N2001/302

Abstract: Systems and methods for coverslipping a sample on a slide employ a coverslip tape. The systems and methods can reduce or eliminate the use of xylene and other toxic solvents for coverslipping.