公开(公告)号：US20150346148A1

公开(公告)日：2015-12-03

申请号：US14289405

申请日：2014-05-28

Applicant: Agilent Technologies, Inc. ,  Agilent Technologies, Inc.

Inventor： Curt A. Flory ,  Arthur Schleifer

IPC: G01N27/447

CPC classification number: B03C5/028

Abstract: An apparatus for controlling the motion of a particle and a method for using the same are disclosed. The apparatus includes a channel containing liquid between first and second electrodes. The apparatus also includes an array of variable impedance elements, each variable impedance element connecting the first electrode to a corresponding location in the channel by a path having an average impedance that is continuously variable between first and second impedances when averaged over an update time interval. A controller sets the average impedance of each of the variable impedance elements such that a particle in the channel moves in a predetermined direction when voltage is applied between the first and second electrodes. At least one of the variable impedance elements has an average impedance that is intermediate between the first and second impedances.

Abstract translation: 公开了一种用于控制颗粒运动的装置及其使用方法。 该装置包括在第一和第二电极之间包含液体的通道。 该装置还包括可变阻抗元件的阵列，每个可变阻抗元件通过具有在更新时间间隔上平均的第一和第二阻抗之间可连续变化的平均阻抗的路径将第一电极连接到通道中的对应位置。 控制器设置每个可变阻抗元件的平均阻抗，使得当在第一和第二电极之间施加电压时，通道中的粒子沿预定方向移动。 至少一个可变阻抗元件具有介于第一和第二阻抗之间的平均阻抗。

公开(公告)号：US09343281B2

公开(公告)日：2016-05-17

申请号：US14470077

申请日：2014-08-27

Applicant: Agilent Technologies, Inc.

Inventor： Curt A. Flory

IPC: H01J49/00 ,  H01J49/42 ,  H01J49/02 ,  H01J49/06 ,  H01J49/26

CPC classification number: H01J49/004 ,  H01J49/0027 ,  H01J49/025 ,  H01J49/063 ,  H01J49/26 ,  H01J49/4285

Abstract: In a tandem mass spectrometry system, a first mass analyzer filters parent ions using a wide mass passband with a narrow rejection notch defined according to a modulation format. A wide mass range of parent ions is transmitted to an ion fragmentation device. Daughter ions produced thereby are transmitted to a second mass analyzer to produce a daughter ion mass spectrum. The modulation of the measured daughter ion mass spectrum, when correlated with the passband modulation of the first mass analyzer (i.e., parent ion spectrum), allows definitive identification of each daughter mass peak with the appropriate parent ion. Due to the wide mass passband, the ion detector signal is in proportion to the increased ion flux passed by the first mass analyzer.

Abstract translation: 在串联质谱系统中，第一质量分析器使用具有根据调制格式限定的窄抑制陷波的宽质量通带滤波母离子。 母体离子的质量范围很宽，被传送到离子碎片装置。 由此产生的子离子传递到第二质量分析器以产生子离子质谱。 当与第一质量分析仪的通带调制（即母离子谱）相关时，测量的子离子质谱的调制允许用合适的母离子确定每个子质谱峰。 由于宽质量通带，离子检测器信号与通过第一质量分析器的离子通量增加成比例。

公开(公告)号：US11791149B2

公开(公告)日：2023-10-17

申请号：US17631393

申请日：2020-07-16

Applicant: Agilent Technologies, Inc.

Inventor： Tong Chen ,  Curt A. Flory ,  Gershon Perelman

IPC: H01J49/06 ,  H01J37/12

CPC classification number: H01J49/067 ,  H01J37/12 ,  H01J2237/1215 ,  H01J2237/1534

Abstract: An electrostatic lens for transporting charged particles in an axial direction includes a first group of first electrodes configured to receive a first DC potential from a DC voltage source, and a second group of second electrodes configured to receive a second DC potential from the DC voltage source different from the first DC potential. The first electrodes are interdigitated with the second electrodes. The first group and/or the second group has a geometric feature that progressively varies along the axial direction. The lens generates an axial potential profile that progressively changes along the axial direction, and thereby reduces geometrical aberrations. The lens may be part of a charged particle processing apparatus such as, for example, a mass spectrometer or an electron microscope.

公开(公告)号：US11515137B2

公开(公告)日：2022-11-29

申请号：US17242040

申请日：2021-04-27

Applicant: Agilent Technologies, Inc.

Inventor： Tong Chen ,  Gershon Perelman ,  Curt A. Flory

IPC: H01J49/06

Abstract: An ion guide includes electrodes elongated along an axis from an entrance end to an exit end and spaced around the axis to surround an interior. The electrodes have polygonal shapes with inside surfaces disposed at a radius from the axis and having an electrode width tangential to a circle inscribed by the electrodes. An aspect ratio of the electrode width to the radius varies along the axis. The electrodes are configured to generate a two-dimensional RF electrical field in the interior having a multipole composition comprising one or more lower-order multipole components and one or more higher-order multipole components and varying along the axis in accordance with the varying aspect ratio, and having an RF voltage amplitude that varies along the axis.

公开(公告)号：US12119214B2

公开(公告)日：2024-10-15

申请号：US17975493

申请日：2022-10-27

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Tong Chen ,  Gershon Perelman ,  Curt A. Flory

IPC: H01J49/06

CPC classification number: H01J49/063 ,  H01J49/065

Abstract: An ion guide includes electrodes elongated along an axis from an entrance end to an exit end and spaced around the axis to surround an interior. The electrodes have polygonal shapes with inside surfaces disposed at a radius from the axis and having an electrode width tangential to a circle inscribed by the electrodes. An aspect ratio of the electrode width to the radius varies along the axis. The electrodes are configured to generate a two-dimensional RF electrical field in the interior having a multipole composition comprising one or more lower-order multipole components and one or more higher-order multipole components and varying along the axis in accordance with the varying aspect ratio, and having an RF voltage amplitude that varies along the axis.

公开(公告)号：US20220336199A1

公开(公告)日：2022-10-20

申请号：US17631393

申请日：2020-07-16

Applicant: Agilent Technologies, Inc.

Inventor： Tong Chen ,  Curt A. Flory ,  Gershon Perelman

IPC: H01J49/06 ,  H01J37/12

Abstract: An electrostatic lens for transporting charged particles in an axial direction includes a first group of first electrodes configured to receive a first DC potential from a DC voltage source, and a second group of second electrodes configured to receive a second DC potential from the DC voltage source different from the first DC potential. The first electrodes are interdigitated with the second electrodes. The first group and/or the second group has a geometric feature that progressively varies along the axial direction. The lens generates an axial potential profile that progressively changes along the axial direction, and thereby reduces geometrical aberrations. The lens may be part of a charged particle processing apparatus such as, for example, a mass spectrometer or an electron microscope.

公开(公告)号：US10010884B1

公开(公告)日：2018-07-03

申请号：US14155266

申请日：2014-01-14

Applicant: Agilent Technologies, Inc.

Inventor： Curt A. Flory ,  Arthur Schleifer ,  Gershon Perelman

IPC: B01D57/02 ,  B01L3/00

CPC classification number: B01L3/502792 ,  B01L3/50273 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/089 ,  B01L2400/0427 ,  B01L2400/0433 ,  B01L2400/0475 ,  F04B19/006

Abstract: A droplet-based microfluidic device having a first confining plate, a second confining plate, and an actuator. Each confining plate includes a respective substrate and hydrophobic layer having a planar major surface. The first confining plate additionally includes a common electrode between its hydrophobic layer and substrate. The second confining plate includes an electrode array between its hydrophobic layer and substrate. The confining plates are disposed opposite one another with their major surfaces separated from one another by a gap. The actuator is to impart oscillatory sliding motion between the confining plates in a direction principally parallel to the major surfaces. The oscillatory sliding motion effectively allows voltages applied between the common electrode and the electrodes of the electrode array to move a microfluidic droplet located in the gap across the major surfaces without sticking.

公开(公告)号：US20240038521A1

公开(公告)日：2024-02-01

申请号：US18485951

申请日：2023-10-12

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Tong CHEN ,  Curt A. Flory ,  Gershon Perelman

IPC: H01J49/06 ,  H01J37/12

CPC classification number: H01J49/067 ,  H01J37/12 ,  H01J2237/1215 ,  H01J2237/1534

Abstract: An electrostatic lens for transporting charged particles in an axial direction includes a first group of first electrodes configured to receive a first DC potential from a DC voltage source, and a second group of second electrodes configured to receive a second DC potential from the DC voltage source different from the first DC potential. The first electrodes are interdigitated with the second electrodes. The first group and/or the second group has a geometric feature that progressively varies along the axial direction. The lens generates an axial potential profile that progressively changes along the axial direction, and thereby reduces geometrical aberrations. The lens may be part of a charged particle processing apparatus such as, for example, a mass spectrometer or an electron microscope.

公开(公告)号：US20210407784A1

公开(公告)日：2021-12-30

申请号：US17242040

申请日：2021-04-27

Applicant: Agilent Technologies, Inc.

Inventor： Tong Chen ,  Gershon Perelman ,  Curt A. Flory

IPC: H01J49/06

Abstract: An ion guide includes electrodes elongated along an axis from an entrance end to an exit end and spaced around the axis to surround an interior. The electrodes have polygonal shapes with inside surfaces disposed at a radius from the axis and having an electrode width tangential to a circle inscribed by the electrodes. An aspect ratio of the electrode width to the radius varies along the axis. The electrodes are configured to generate a two-dimensional RF electrical field in the interior having a multipole composition comprising one or more lower-order multipole components and one or more higher-order multipole components and varying along the axis in accordance with the varying aspect ratio, and having an RF voltage amplitude that varies along the axis.

公开(公告)号：US20150279640A1

公开(公告)日：2015-10-01

申请号：US14470077

申请日：2014-08-27

Applicant: Agilent Technologies, Inc.

Inventor： Curt A. Flory

IPC: H01J49/00 ,  H01J49/02 ,  H01J49/06 ,  H01J49/26

CPC classification number: H01J49/004 ,  H01J49/0027 ,  H01J49/025 ,  H01J49/063 ,  H01J49/26 ,  H01J49/4285

Abstract: In a tandem mass spectrometry system, a first mass analyzer filters parent ions using a wide mass passband with a narrow rejection notch defined according to a modulation format. A wide mass range of parent ions is transmitted to an ion fragmentation device. Daughter ions produced thereby are transmitted to a second mass analyzer to produce a daughter ion mass spectrum. The modulation of the measured daughter ion mass spectrum, when correlated with the passband modulation of the first mass analyzer (i.e., parent ion spectrum), allows definitive identification of each daughter mass peak with the appropriate parent ion. Due to the wide mass passband, the ion detector signal is in proportion to the increased ion flux passed by the first mass analyzer.

Abstract translation: 在串联质谱系统中，第一质量分析器使用具有根据调制格式限定的窄抑制陷波的宽质量通带滤波母离子。 母体离子的质量范围很宽，被传送到离子碎片装置。 由此产生的子离子传递到第二质量分析器以产生子离子质谱。 当与第一质量分析仪的通带调制（即母离子谱）相关时，测量的子离子质谱的调制允许用合适的母离子确定每个子质谱峰。 由于宽质量通带，离子检测器信号与通过第一质量分析器的离子通量增加成比例。