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公开(公告)号：US11643440B2
公开(公告)日：2023-05-09
申请号：US16619874
申请日：2018-06-01
Applicant: AMGEN INC.
Inventor： Irwin Chen , Su Chong , Essa Hu Harrington , Fang-Tsao Hong , Jason C. Long , Leslie P. Miranda
CPC classification number: C07K14/001 , A61P25/06 , A61K38/00
Abstract: Novel peptides that bind to human PAC1 are provided. These peptides that are antagonists of PAC1 are useful in a number of PAC1 related disorders, including the treatment and/or prevention of headache disorders, including migraine, such as acute migraine.
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公开(公告)号：US20130253186A1
公开(公告)日：2013-09-26
申请号：US13892196
申请日：2013-05-10
Applicant: Amgen Inc.
Inventor： Jennifer R. Allen , Daniel B. Horne , Essa Hu Harrington , Matthew R. Kaller , Holger Monenschein , Thomas T. Nguyen , Andreas Reichelt , Robert M. Rzasa
IPC: C07D491/107 , C07D403/04 , C07D487/04 , C07D403/14 , C07D401/14 , C07D487/10 , C07D401/04 , C07D405/04 , C07D401/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04
CPC classification number: C07D491/107 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/10
Abstract: Heteroaryloxyheterocyclyl compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, Huntington's Disease, bipolar disorder, obsessive-compulsive disorder, and the like.
Abstract translation: 杂环氧基杂环基化合物和含有它们的组合物，以及这些化合物的制备方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，亨廷顿舞蹈病，双相情感障碍，强迫症等。
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公开(公告)号：US20160280703A1
公开(公告)日：2016-09-29
申请号：US14579733
申请日：2014-12-22
Applicant: Amgen Inc.
Inventor： Jennifer R. Allen , Michael J. Frohn , Paul E. Harrington , Essa Hu Harrington , Alexander J. Pickrell
IPC: C07D417/14 , C07D413/14 , C07D471/04 , C07D417/12 , C07D487/04 , C07D405/14 , C07D401/14
CPC classification number: C07D417/14 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04
Abstract: Heteroaryloxycarbocyclyl compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, Huntington's Disease, bipolar disorder, obsessive-compulsive disorder, and the like.
Abstract translation: 杂芳氧基碳环化合物和含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，亨廷顿舞蹈病，双相情感障碍，强迫症等。
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公开(公告)号：US09376450B2
公开(公告)日：2016-06-28
申请号：US13892196
申请日：2013-05-10
Applicant: Amgen Inc.
Inventor： Jennifer R. Allen , Daniel B. Horne , Essa Hu Harrington , Matthew R. Kaller , Holger Monenschein , Thomas T. Nguyen , Andreas Reichelt , Robert M. Rzasa
IPC: C07D491/107 , C07D413/14 , C07D403/04 , C07D403/14 , C07D487/04 , C07D487/10 , C07D401/04 , C07D401/06 , C07D405/14 , C07D405/04 , C07D401/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D409/14
CPC classification number: C07D491/107 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/10
Abstract: Heteroaryloxyheterocyclyl compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, Huntington's Disease, bipolar disorder, obsessive-compulsive disorder, and the like.
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公开(公告)号：US20130225552A1
公开(公告)日：2013-08-29
申请号：US13780557
申请日：2013-02-28
Applicant: Amgen Inc.
Inventor： Jennifer R. Allen , Albert Amegadzie , Kristin L. Andrews , James Brown , Jian J. Chen , Ning Chen , Essa Hu Harrington , Qingyian Liu , Thomas T. Nguyen , Alexander J. Pickrell , Wenyuan Qian , Shannon Rumfelt , Robert M. Rzasa , Chester Chenguang Yuan , Wenge Zhong
IPC: C07D487/04 , C07D513/04 , C07D471/04 , C07D498/04 , C07D473/00
CPC classification number: C07D487/04 , C07D417/12 , C07D471/04 , C07D473/00 , C07D473/30 , C07D473/34 , C07D473/40 , C07D498/04 , C07D513/04 , C07D519/00
Abstract: Heterobicyclic compounds of Formula (I): or a pharmaceutically-acceptable salt, tautomer, or stereoisomer thereof, as defined in the specification, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, Huntington's Disease, and the like.
Abstract translation: 式（I）的异双环化合物：或其药学上可接受的盐，互变异构体或立体异构体，以及含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，双相情感障碍，强迫症，亨廷顿舞蹈病等。
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Patent Agency Ranking
公开(公告)号：US09394297B2
公开(公告)日：2016-07-19
申请号：US14380918
申请日：2013-02-27
Applicant: AMGEN INC.
Inventor： Victor Cee , Frank Chavez, Jr. , Jian J. Chen , Essa Hu Harrington , Bradley Herberich , Claire L. M. Jackson , Brian A. Lanman , Thomas T. Nguyen , Mark H. Norman , Liping H. Pettus , Anthony B. Reed , Adrian L. Smith , Nuria A. Tamayo , Andrew Tasker , Hui-Ling Wang , Bin Wu , Ryan Wurz
IPC: C07D401/04 , C07D471/04 , C07D487/04
CPC classification number: C07D471/04 , C07D401/04 , C07D487/04
Abstract: The invention relates to amide-containing compounds of formula (1), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
Abstract translation: 本发明涉及式（1）的含酰胺化合物及其盐。 在一些实施方案中，本发明涉及Pim-1和/或Pim-2和/或Pim-3蛋白激酶活性或酶功能的抑制剂或调节剂。 在另外的实施方案中，本发明涉及包含本文公开的化合物的药物组合物及其在预防和治疗Pim激酶相关病症和疾病，优选癌症中的用途。
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公开(公告)号：US09174992B2
公开(公告)日：2015-11-03
申请号：US13780557
申请日：2013-02-28
Applicant: Amgen Inc.
Inventor： Jennifer R. Allen , Albert Amegadzie , Kristin L. Andrews , James Brown , Jian J. Chen , Ning Chen , Essa Hu Harrington , Qingyian Liu , Thomas T. Nguyen , Alexander J. Pickrell , Wenyuan Qian , Shannon Rumfelt , Robert M. Rzasa , Chester Chenguang Yuan , Wenge Zhong
IPC: C07D419/14 , C07D419/12 , C07D487/04 , C07D498/04 , C07D473/00 , C07D471/04 , C07D513/04 , C07D417/12 , C07D473/30 , C07D473/34 , C07D473/40 , C07D519/00
CPC classification number: C07D487/04 , C07D417/12 , C07D471/04 , C07D473/00 , C07D473/30 , C07D473/34 , C07D473/40 , C07D498/04 , C07D513/04 , C07D519/00
Abstract: Heterobicyclic compounds of Formula (I): or a pharmaceutically-acceptable salt, tautomer, or stereoisomer thereof, as defined in the specification, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, Huntington's Disease, and the like.
Abstract translation: 式（I）的异双环化合物：或其药学上可接受的盐，互变异构体或立体异构体，以及含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，双相情感障碍，强迫症，亨廷顿舞蹈病等。
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公开(公告)号：US09718803B2
公开(公告)日：2017-08-01
申请号：US14973491
申请日：2015-12-17
Applicant: AMGEN INC.
Inventor： Jennifer R. Allen , Jian J. Chen , Michael J. Frohn , Essa Hu Harrington , Qingyian Liu , Alexander J. Pickrell , Shannon Rumfelt , Robert M. Rzasa , Wenge Zhong
IPC: C07D401/14 , A61K31/497 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D491/08 , C07D487/08 , C07D487/10 , C07D491/107 , C07C53/18 , C07D491/056 , C07D513/04
CPC classification number: C07D401/14 , C07C53/18 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/056 , C07D491/08 , C07D491/107 , C07D513/04
Abstract: Unsaturated nitrogen heterocyclic compounds of formula (I): as defined in the specification, compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, Huntington's Disease, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
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9.发明申请公开(公告)号：US20140213572A1
公开(公告)日：2014-07-31
申请号：US14242432
申请日：2014-04-01
Applicant: AMGEN INC.
Inventor： Jennifer R. Allen , Jian J. Chen , Michael J. Frohn , Essa Hu Harrington , Qingyian Liu , Alexander J. Pickrell , Shannon Rumfelt , Robert M. Rzasa , Wenge Zhong
IPC: C07D403/14 , C07D417/14 , C07D409/14 , C07D413/14 , C07D487/08 , C07D487/10 , C07D405/14 , C07D487/04 , C07D491/08 , C07D401/14 , C07D491/107
CPC classification number: C07D401/14 , C07C53/18 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/056 , C07D491/08 , C07D491/107 , C07D513/04
Abstract: Unsaturated nitrogen heterocyclic compounds of formula (I): as defined in the specification, compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, Huntington's Disease, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
Abstract translation: 式（I）的不饱和氮杂环化合物：如说明书中所定义，含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，亨廷顿舞蹈病，非胰岛素依赖性糖尿病，精神分裂症，双相障碍，强迫症等。
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10.发明授权公开(公告)号：US08759532B2
公开(公告)日：2014-06-24
申请号：US13676826
申请日：2012-11-14
Applicant: AMGEN Inc.
Inventor： Jennifer R. Allen , Kaustav Biswas , Frank Chavez, Jr. , Ning Chen , Frenel Fils De Morin , James R. Falsey , Michael J. Frohn , Paul E. Harrington , Daniel B. Home , Essa Hu Harrington , Matthew R. Kaller , Roxanne K. Kunz , Holger Monenschein , Thomas T. Nguyen , Alexander J. Pickrell , Andreas Reichelt , Shannon Rumfelt , Robert M. Rzasa , Kelvin Sham , Guomin Yao
IPC: C07D239/02 , A61K31/397
CPC classification number: C07D413/14 , C07D401/12 , C07D401/14 , C07D417/12 , C07D471/04 , C07D473/00
Abstract: Pyridine and pyrimidine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
Abstract translation: 吡啶和嘧啶化合物，以及含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖型糖尿病，精神分裂症，双相情感障碍，强迫症等。
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