公开(公告)号：US11643440B2

公开(公告)日：2023-05-09

申请号：US16619874

申请日：2018-06-01

Applicant: AMGEN INC.

Inventor： Irwin Chen ,  Su Chong ,  Essa Hu Harrington ,  Fang-Tsao Hong ,  Jason C. Long ,  Leslie P. Miranda

IPC: C07K14/00 ,  A61P25/06 ,  A61K38/00

CPC classification number: C07K14/001 ,  A61P25/06 ,  A61K38/00

Abstract: Novel peptides that bind to human PAC1 are provided. These peptides that are antagonists of PAC1 are useful in a number of PAC1 related disorders, including the treatment and/or prevention of headache disorders, including migraine, such as acute migraine.