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Patent Agency Ranking
公开(公告)号：US20140171639A1
公开(公告)日：2014-06-19
申请号：US14187677
申请日：2014-02-24
Applicant: AMGEN INC.
Inventor： Kaustav Biswas , James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Vu Van Ma , Holger Monenschein , Thomas T. Nguyen , David J. St. Jean, JR. , Chester Chenguang Yuan , Wenge Zhong
IPC: C07D401/12 , C07D471/04 , C07D487/04 , C07D413/12 , C07D498/04 , C07D417/12 , C07D409/12 , C07D405/14 , C07D405/12 , C07D401/14 , C07D213/61
CPC classification number: C07D213/82 , C07D213/40 , C07D213/61 , C07D213/81 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04
Abstract: Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
Abstract translation: 式I的化合物可用作TRPM8的拮抗剂。 这些化合物可用于治疗多种TRPM8介导的病症和病症，并且可用于制备用于治疗这种病症和病症的药物和药物组合物。 这些疾病的实例包括但不限于偏头痛和神经性疼痛。 式I的化合物具有以下结构：其中本文提供变量的定义。
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公开(公告)号：US09174992B2
公开(公告)日：2015-11-03
申请号：US13780557
申请日：2013-02-28
Applicant: Amgen Inc.
Inventor： Jennifer R. Allen , Albert Amegadzie , Kristin L. Andrews , James Brown , Jian J. Chen , Ning Chen , Essa Hu Harrington , Qingyian Liu , Thomas T. Nguyen , Alexander J. Pickrell , Wenyuan Qian , Shannon Rumfelt , Robert M. Rzasa , Chester Chenguang Yuan , Wenge Zhong
IPC: C07D419/14 , C07D419/12 , C07D487/04 , C07D498/04 , C07D473/00 , C07D471/04 , C07D513/04 , C07D417/12 , C07D473/30 , C07D473/34 , C07D473/40 , C07D519/00
CPC classification number: C07D487/04 , C07D417/12 , C07D471/04 , C07D473/00 , C07D473/30 , C07D473/34 , C07D473/40 , C07D498/04 , C07D513/04 , C07D519/00
Abstract: Heterobicyclic compounds of Formula (I): or a pharmaceutically-acceptable salt, tautomer, or stereoisomer thereof, as defined in the specification, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, Huntington's Disease, and the like.
Abstract translation: 式（I）的异双环化合物：或其药学上可接受的盐，互变异构体或立体异构体，以及含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，双相情感障碍，强迫症，亨廷顿舞蹈病等。
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公开(公告)号：US20140171406A1
公开(公告)日：2014-06-19
申请号：US14187732
申请日：2014-02-24
Applicant: AMGEN INC.
Inventor： Kaustav Biswas , James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Vu Van Ma , Holger Monenschein , Thomas T. Nguyen , David J. St. Jean, JR. , Chester Chenguang Yuan , Wenge Zhong
IPC: C07D487/04 , C07D401/14 , C07D401/12 , C07D213/82 , C07D413/12 , C07D471/04
CPC classification number: C07D213/82 , C07D213/40 , C07D213/61 , C07D213/81 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04
Abstract: Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
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公开(公告)号：US20130225552A1
公开(公告)日：2013-08-29
申请号：US13780557
申请日：2013-02-28
Applicant: Amgen Inc.
Inventor： Jennifer R. Allen , Albert Amegadzie , Kristin L. Andrews , James Brown , Jian J. Chen , Ning Chen , Essa Hu Harrington , Qingyian Liu , Thomas T. Nguyen , Alexander J. Pickrell , Wenyuan Qian , Shannon Rumfelt , Robert M. Rzasa , Chester Chenguang Yuan , Wenge Zhong
IPC: C07D487/04 , C07D513/04 , C07D471/04 , C07D498/04 , C07D473/00
CPC classification number: C07D487/04 , C07D417/12 , C07D471/04 , C07D473/00 , C07D473/30 , C07D473/34 , C07D473/40 , C07D498/04 , C07D513/04 , C07D519/00
Abstract: Heterobicyclic compounds of Formula (I): or a pharmaceutically-acceptable salt, tautomer, or stereoisomer thereof, as defined in the specification, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, Huntington's Disease, and the like.
Abstract translation: 式（I）的异双环化合物：或其药学上可接受的盐，互变异构体或立体异构体，以及含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，双相情感障碍，强迫症，亨廷顿舞蹈病等。
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公开(公告)号：US09096527B2
公开(公告)日：2015-08-04
申请号：US14187677
申请日：2014-02-24
Applicant: AMGEN INC.
Inventor： Kaustav Biswas , James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Vu Van Ma , Holger Monenschein , Thomas T. Nguyen , David J. St. Jean, Jr. , Chester Chenguang Yuan , Wenge Zhong
IPC: C07D498/04 , C07D401/12 , C07D471/04 , C07D213/81 , C07D213/82 , C07D213/40 , C07D213/61 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/04
CPC classification number: C07D213/82 , C07D213/40 , C07D213/61 , C07D213/81 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04
Abstract: Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
Abstract translation: 式I的化合物可用作TRPM8的拮抗剂。 这些化合物可用于治疗多种TRPM8介导的病症和病症，并且可用于制备用于治疗这种病症和病症的药物和药物组合物。 这些疾病的实例包括但不限于偏头痛和神经性疼痛。 式I的化合物具有以下结构：其中本文提供变量的定义。
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