Invention Grant
- Patent Title: Amides as pim inhibitors
- Patent Title (中): 酰胺作为抑制剂
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Application No.: US14380918Application Date: 2013-02-27
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Publication No.: US09394297B2Publication Date: 2016-07-19
- Inventor: Victor Cee , Frank Chavez, Jr. , Jian J. Chen , Essa Hu Harrington , Bradley Herberich , Claire L. M. Jackson , Brian A. Lanman , Thomas T. Nguyen , Mark H. Norman , Liping H. Pettus , Anthony B. Reed , Adrian L. Smith , Nuria A. Tamayo , Andrew Tasker , Hui-Ling Wang , Bin Wu , Ryan Wurz
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agent Bernard P. Friedrichsen
- International Application: PCT/US2013/028087 WO 20130227
- International Announcement: WO2013/013066 WO 20130906
- Main IPC: C07D401/04
- IPC: C07D401/04 ; C07D471/04 ; C07D487/04
Abstract:
The invention relates to amide-containing compounds of formula (1), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
Public/Granted literature
- US20150329538A1 AMIDES AS PIM INHIBITORS Public/Granted day:2015-11-19
Information query
