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公开(公告)号：US09394297B2
公开(公告)日：2016-07-19
申请号：US14380918
申请日：2013-02-27
Applicant: AMGEN INC.
Inventor： Victor Cee , Frank Chavez, Jr. , Jian J. Chen , Essa Hu Harrington , Bradley Herberich , Claire L. M. Jackson , Brian A. Lanman , Thomas T. Nguyen , Mark H. Norman , Liping H. Pettus , Anthony B. Reed , Adrian L. Smith , Nuria A. Tamayo , Andrew Tasker , Hui-Ling Wang , Bin Wu , Ryan Wurz
IPC: C07D401/04 , C07D471/04 , C07D487/04
CPC classification number: C07D471/04 , C07D401/04 , C07D487/04
Abstract: The invention relates to amide-containing compounds of formula (1), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
Abstract translation: 本发明涉及式（1）的含酰胺化合物及其盐。 在一些实施方案中，本发明涉及Pim-1和/或Pim-2和/或Pim-3蛋白激酶活性或酶功能的抑制剂或调节剂。 在另外的实施方案中，本发明涉及包含本文公开的化合物的药物组合物及其在预防和治疗Pim激酶相关病症和疾病，优选癌症中的用途。
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公开(公告)号：US11285135B2
公开(公告)日：2022-03-29
申请号：US16675121
申请日：2019-11-05
Applicant: AMGEN INC.
Inventor： Brian Alan Lanman , Victor J. Cee , Alexander J. Pickrell , Anthony B. Reed , Kevin C. Yang , David John Kopecky , Hui-Ling Wang , Patricia Lopez , Kate Ashton , Shon Booker , Christopher M. Tegley
IPC: C07D417/04 , C07D417/14 , C07D513/04 , A61K31/428 , A61K31/496 , A61K31/519 , A61P35/00 , A61K31/5025 , A61K31/502 , A61K31/517 , C07D275/04 , C07D471/08 , C07D403/04 , C07D401/04 , C07D487/04 , C07D239/80 , C07D487/10 , C07D471/04
Abstract: Provided herein are methods of treating cancer with KRAS G12C inhibitors of Formula I and compositions of the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US11090304B2
公开(公告)日：2021-08-17
申请号：US16402538
申请日：2019-05-03
Applicant: Amgen Inc.
Inventor： John Gordon Allen , Jennifer Rebecca Allen , Ana Elena Minatti , Qiufen Xue , Ryan Paul Wurz , Christopher M. Tegley , Alexander J. Pickrell , Thomas T. Nguyen , Vu Van Ma , Patricia Lopez , Longbin Liu , David John Kopecky , Michael J. Frohn , Ning Chen , Jian Jeffrey Chen , Aaron C. Siegmund , Albert Amegadzie , Nuria A. Tamayo , Shon Booker , Clifford Goodman , Mary Walton , Nobuko Nishimura , Youngsook Shin , Jonathan D. Low , Victor J. Cee , Anthony B. Reed , Hui-Ling Wang , Brian Alan Lanman
IPC: A61K31/517 , A61P35/00 , A61K31/4985 , A61K39/395 , C07D403/04 , C07D471/04
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US12083121B2
公开(公告)日：2024-09-10
申请号：US17579359
申请日：2022-01-19
Applicant: AMGEN INC.
Inventor： John Gordon Allen , Brian Alan Lanman , Jian Chen , Anthony B. Reed , Victor J. Cee , Longbin Liu , Patricia Lopez , Ryan Paul Wurz , Thomas T. Nguyen , Shon Booker , Jennifer Rebecca Allen , Margaret Chu-Moyer , Albert Amegadzie , Ning Chen , Clifford Goodman , Jonathan D. Low , Vu Van Ma , Ana Elena Minatti , Nobuko Nishimura , Alexander J. Pickrell , Hui-Ling Wang , Youngsook Shin , Aaron C. Siegmund , Kevin C. Yang , Nuria A. Tamayo , Mary Walton , Qiufen Xue
IPC: C07D241/04 , A61K31/519 , A61K31/551 , A61K39/395 , A61P35/00
CPC classification number: A61K31/519 , A61K31/551 , A61K39/39558 , A61P35/00
Abstract: Provided herein are KRAS G12C inhibitors, such as
composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.-
Patent Agency Ranking
公开(公告)号：US11993597B2
公开(公告)日：2024-05-28
申请号：US17692026
申请日：2022-03-10
Applicant: Amgen Inc.
Inventor： Brian Alan Lanman , Shon Booker , Clifford Goodman , Anthony B. Reed , Jonathan D. Low , Hui-Ling Wang , Ning Chen , Ana Elena Minatti , Ryan Wurz , Victor J. Cee
IPC: C07D471/04 , A61K31/519 , A61P35/00 , A61K31/7068 , A61K38/07
CPC classification number: C07D471/04 , A61K31/519 , A61P35/00 , A61K31/7068 , A61K38/07 , A61K2300/00
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US11766436B2
公开(公告)日：2023-09-26
申请号：US17363878
申请日：2021-06-30
Applicant: Amgen Inc.
Inventor： John Gordon Allen , Jennifer Rebecca Allen , Ana Elena Minatti , Qiufen Xue , Ryan Paul Wurz , Christopher M. Tegley , Alexander J. Pickrell , Thomas T. Nguyen , Vu Van Ma , Patricia Lopez , Longbin Liu , David John Kopecky , Michael J. Frohn , Ning Chen , Jian Jeffrey Chen , Aaron C. Siegmund , Albert Amegadzie , Nuria A. Tamayo , Shon Booker , Clifford Goodman , Mary Walton , Nobuko Nishimura , Youngsook Shin , Jonathan D. Low , Victor J. Cee , Anthony B. Reed , Hui-Ling Wang , Brian Alan Lanman
IPC: A61K31/517 , A61P35/00 , A61K31/4985 , A61K39/395 , C07D403/04 , C07D471/04
CPC classification number: A61K31/517 , A61K31/4985 , A61K39/39558 , A61P35/00 , C07D403/04 , C07D471/04
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US11306087B2
公开(公告)日：2022-04-19
申请号：US16817109
申请日：2020-03-12
Applicant: Amgen Inc.
Inventor： Brian Alan Lanman , Shon Booker , Clifford Goodman , Anthony B. Reed , Jonathan D. Low , Hui-Ling Wang , Ning Chen , Ana Elena Minatti , Ryan Wurz , Victor J. Cee
IPC: C07D471/04 , A61P35/00 , A61K31/519 , A61K31/7068 , A61K38/07
Abstract: Provided herein are methods of using KRAS G12C inhibitors. These methods of using the inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US11285156B2
公开(公告)日：2022-03-29
申请号：US16438349
申请日：2019-06-11
Applicant: Amgen Inc.
Inventor： John Gordon Allen , Brian Alan Lanman , Jian Chen , Anthony B. Reed , Victor J. Cee , Longbin Liu , Patricia Lopez , Ryan Paul Wurz , Thomas T. Nguyen , Shon Booker , Jennifer Rebecca Allen , Margaret Chu-Moyer , Albert Amegadzie , Ning Chen , Clifford Goodman , Jonathan D. Low , Vu Van Ma , Ana Elena Minatti , Nobuko Nishimura , Alexander J. Pickrell , Hui-Ling Wang , Youngsook Shin , Aaron C. Siegmund , Kevin C. Yang , Nuria A. Tamayo , Mary Walton , Qiufen Xue
IPC: A61K31/497 , C07D241/04 , A61K31/519 , A61K31/551 , A61K39/395 , A61P35/00
Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US10532042B2
公开(公告)日：2020-01-14
申请号：US15849905
申请日：2017-12-21
Applicant: AMGEN INC.
Inventor： Brian Alan Lanman , Victor J. Cee , Alexander J. Pickrell , Anthony B. Reed , Kevin C. Yang , David John Kopecky , Hui-Ling Wang , Patricia Lopez , Kate Ashton , Shon Booker , Christopher M. Tegley
IPC: C07D487/04 , A61K31/428 , A61K31/496 , A61K31/519 , A61P35/00 , A61K31/5025 , A61K31/502 , A61K31/517 , C07D401/04 , C07D403/04 , C07D239/80 , C07D417/04 , C07D471/04 , C07D471/08 , C07D487/10 , C07D275/04 , C07D513/04
Abstract: Provided herein are KRAS G12C inhibitors, compounds of formula (II), or a pharmaceutically acceptable salt thereof: compositions of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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