专利检索 ap:("Amgen Inc.") AND inv:"Nuria A. Tamayo" 第 1 页

1.

发明授权
Fused multi-cyclic sulfone compounds as inhibitors of beta-secretase and methods of use thereof 有权
标题翻译：熔融多环砜化合物作为β-分泌酶的抑制剂及其使用方法

公开(公告)号：US09309263B2

公开(公告)日：2016-04-12

申请号：US14166012

申请日：2014-01-28

申请人： AMGEN INC.

发明人： Ryan White , Jennifer R. Allen , Oleg Epstein , Fang-Tsao Hong , Zihao Hua , Jason Brooks Human , Patricia Lopez , Philip R. Olivieri , Karina Romero , Laurie Schenkel , John Stellwagen , Nuria A. Tamayo , Xiao Mei Zheng

IPC分类号： C07D417/10 , C07D417/14 , C07D513/04 , C07D513/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/10 , C07D513/20 , C07D519/00

CPC分类号： C07D513/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/10 , C07D513/14 , C07D513/20 , C07D519/00

摘要： The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A5, A6, A8, R1, R2, R3, R7, X, Y, n and o of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formula II and sub-formula embodiments thereof, compounds of Formula III, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III, and sub-Formulas thereof.

摘要翻译： 本发明提供了一类可用于调节β-分泌酶（BACE）活性的化合物。化合物具有通式I：其中式I的变量A5，A6，A8，R1，R2，R3，R7，X，Y，n和o独立地在本文中定义。本发明还提供包含该化合物的药物组合物，以及用于治疗由BACE的生物学活性产生的A-β斑块形成和沉积相关的病症和/或病症的化合物和组合物的相应用途。这种BACE介导的疾病包括例如阿尔茨海默病，认知缺陷，认知障碍，精神分裂症和其他中枢神经系统疾病。本发明还提供式II化合物及其次级实施方案，式III化合物，可用于制备式I-III化合物的中间体和方法和方法及其分式。

2.

发明授权
KRAS G12C inhibitors and methods of using the same 有权

公开(公告)号：US11090304B2

公开(公告)日：2021-08-17

申请号：US16402538

申请日：2019-05-03

申请人： Amgen Inc.

发明人： John Gordon Allen , Jennifer Rebecca Allen , Ana Elena Minatti , Qiufen Xue , Ryan Paul Wurz , Christopher M. Tegley , Alexander J. Pickrell , Thomas T. Nguyen , Vu Van Ma , Patricia Lopez , Longbin Liu , David John Kopecky , Michael J. Frohn , Ning Chen , Jian Jeffrey Chen , Aaron C. Siegmund , Albert Amegadzie , Nuria A. Tamayo , Shon Booker , Clifford Goodman , Mary Walton , Nobuko Nishimura , Youngsook Shin , Jonathan D. Low , Victor J. Cee , Anthony B. Reed , Hui-Ling Wang , Brian Alan Lanman

IPC分类号： A61K31/517 , A61P35/00 , A61K31/4985 , A61K39/395 , C07D403/04 , C07D471/04

摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

3.

发明授权
KRAS G12C inhibitors and methods of using the same 有权

公开(公告)号：US10519146B2

公开(公告)日：2019-12-31

申请号：US15984855

申请日：2018-05-21

申请人： Amgen Inc.

发明人： Brian Alan Lanman , Jian Chen , Anthony B. Reed , Victor J. Cee , Longbin Liu , David John Kopecky , Patricia Lopez , Ryan Paul Wurz , Thomas T. Nguyen , Shon Booker , Nobuko Nishimura , Youngsook Shin , Nuria A. Tamayo , John Gordon Allen , Jennifer Rebecca Allen

IPC分类号： C07D471/04 , C07D487/04 , C07D403/04 , C07D401/04 , C07D475/00 , A61K31/496 , A61K31/519 , A61P35/00 , C07D417/04 , A61K38/07 , C07D487/08 , C07D417/12 , C07D513/04 , C07D487/10 , C07D239/80 , C07D401/14 , C07D237/34 , A61K31/416 , A61K31/55 , A61K31/454 , A61K31/517 , A61K31/502 , A61K31/5025 , A61K31/7068 , C07D275/04

摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

4.

发明授权
Perfluorinated 5,6-dihydro-4H-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use 有权
标题翻译：全氟化的5,6-二氢-4H-1,3-恶嗪-2-胺化合物作为β-分泌酶抑制剂和使用方法

公开(公告)号：US09296734B2

公开(公告)日：2016-03-29

申请号：US14192710

申请日：2014-02-27

申请人： AMGEN INC.

发明人： Ana Elena Minatti , Jonathan D. Low , Jennifer R. Allen , Jian Chen , Ning Chen , Yuan Cheng , Ted Judd , Qingyian Liu , Patricia Lopez , Wenyuan Qian , Shannon Rumfelt , Robert M. Rzasa , Nuria A. Tamayo , Qiufen Xue , Bryant Yang , Wenge Zhong

IPC分类号： C07D413/14 , C07D413/12 , C07D471/04 , C07D513/04 , C07F7/08 , C07D413/04 , C07D413/10 , C07D265/08 , C07D498/04

CPC分类号： C07D413/14 , C07D265/08 , C07D413/04 , C07D413/10 , C07D413/12 , C07D471/04 , C07D498/04 , C07D513/04 , C07F7/0812

摘要： The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, each of R1 and R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III.

摘要翻译： 本发明提供了一类可用于调节β-分泌酶（BACE）活性的化合物。化合物具有通式I：其中式I中的各个R 1和R 2，R 3和R 7各自独立地定义的变量A4，A5，A6，A8在本文中定义。本发明还提供包含该化合物的药物组合物，以及用于治疗由BACE的生物学活性产生的A-β斑块形成和沉积相关的病症和/或病症的化合物和组合物的相应用途。这种BACE介导的疾病包括例如阿尔茨海默病，认知缺陷，认知障碍，精神分裂症和其他中枢神经系统疾病。本发明还提供式II和III的化合物及其分式实施方案，可用于制备式I-III化合物的中间体和方法和方法。

5.

发明授权
KIF18A inhibitors 有权

公开(公告)号：US12054476B2

公开(公告)日：2024-08-06

申请号：US17551105

申请日：2021-12-14

申请人： AMGEN INC.

发明人： Nuria A. Tamayo , Abhisek Banerjee , James Alexander Brown , Michael J Frohn , Jian Jeffrey Chen , Kexue Li , Qingyian Liu , Jonathan Dante Low , Vu Ma , Liping H. Pettus , Mary Catherine Walton , Ana Elena Minatti , Matthew Paul Bourbeau , Lei Jia

IPC分类号： C07D401/14 , C07D401/12 , C07D405/14 , C07D413/14 , C07D419/14 , C07D491/107

CPC分类号： C07D401/14 , C07D401/12 , C07D405/14 , C07D413/14 , C07D419/14 , C07D491/107

摘要： Compounds of formula (I):

as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

6.

发明授权
KIF18A inhibitors 有权

公开(公告)号：US11236069B2

公开(公告)日：2022-02-01

申请号：US16724119

申请日：2019-12-20

申请人： AMGEN INC.

发明人： Nuria A. Tamayo , Abhisek Banerjee , Jian Jeffrey Chen , Jonathan Dante Low , Ana Elena Minatti , Matthew Paul Bourbeau

IPC分类号： C07D401/14 , C07D401/12 , C07D405/14 , C07D413/14 , C07D419/14 , C07D491/107

摘要： Compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

7.

发明授权
Amides as pim inhibitors 有权
标题翻译：酰胺作为抑制剂

公开(公告)号：US09394297B2

公开(公告)日：2016-07-19

申请号：US14380918

申请日：2013-02-27

申请人： AMGEN INC.

发明人： Victor Cee , Frank Chavez, Jr. , Jian J. Chen , Essa Hu Harrington , Bradley Herberich , Claire L. M. Jackson , Brian A. Lanman , Thomas T. Nguyen , Mark H. Norman , Liping H. Pettus , Anthony B. Reed , Adrian L. Smith , Nuria A. Tamayo , Andrew Tasker , Hui-Ling Wang , Bin Wu , Ryan Wurz

IPC分类号： C07D401/04 , C07D471/04 , C07D487/04

CPC分类号： C07D471/04 , C07D401/04 , C07D487/04

摘要： The invention relates to amide-containing compounds of formula (1), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.

摘要翻译： 本发明涉及式（1）的含酰胺化合物及其盐。在一些实施方案中，本发明涉及Pim-1和/或Pim-2和/或Pim-3蛋白激酶活性或酶功能的抑制剂或调节剂。在另外的实施方案中，本发明涉及包含本文公开的化合物的药物组合物及其在预防和治疗Pim激酶相关病症和疾病，优选癌症中的用途。