公开(公告)号：US20180289720A1

公开(公告)日：2018-10-11

申请号：US15938001

申请日：2018-03-28

申请人： AMGEN INC.

发明人： Paul E. Harrington ,  Kate Ashton ,  Sean P. Brown ,  Matthew R. Kaller ,  Todd J. Kohn ,  Brian Alan Lanman ,  Kexue Li ,  Yunxiao Li ,  Jonathan D. Low ,  Ana Elena Minatti ,  Alexander J. Pickrell ,  Markian M. Stec ,  Joshua Taygerly

IPC分类号： A61K31/553 ,  A61P35/00

CPC分类号： A61K31/553 ,  A61P35/00 ,  A61P35/02 ,  C07D498/08

摘要： Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

公开(公告)号：US11285135B2

公开(公告)日：2022-03-29

申请号：US16675121

申请日：2019-11-05

申请人： AMGEN INC.

发明人： Brian Alan Lanman ,  Victor J. Cee ,  Alexander J. Pickrell ,  Anthony B. Reed ,  Kevin C. Yang ,  David John Kopecky ,  Hui-Ling Wang ,  Patricia Lopez ,  Kate Ashton ,  Shon Booker ,  Christopher M. Tegley

IPC分类号： C07D417/04 ,  C07D417/14 ,  C07D513/04 ,  A61K31/428 ,  A61K31/496 ,  A61K31/519 ,  A61P35/00 ,  A61K31/5025 ,  A61K31/502 ,  A61K31/517 ,  C07D275/04 ,  C07D471/08 ,  C07D403/04 ,  C07D401/04 ,  C07D487/04 ,  C07D239/80 ,  C07D487/10 ,  C07D471/04

摘要： Provided herein are methods of treating cancer with KRAS G12C inhibitors of Formula I and compositions of the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：US11224601B1

公开(公告)日：2022-01-18

申请号：US17029249

申请日：2020-09-23

申请人： AMGEN INC.

发明人： Paul E. Harrington ,  Kate Ashton ,  Sean P. Brown ,  Matthew R. Kaller ,  Todd J. Kohn ,  Brian Alan Lanman ,  Kexue Li ,  Yunxiao Li ,  Jonathan D. Low ,  Ana Elena Minatti ,  Alexander J. Pickrell ,  Markian M. Stec ,  Joshua Taygerly

IPC分类号： A61K31/553 ,  A61P35/02 ,  A61P35/00 ,  C07D498/08

摘要： Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

公开(公告)号：US10821115B2

公开(公告)日：2020-11-03

申请号：US16783269

申请日：2020-02-06

申请人： AMGEN INC.

发明人： Paul E. Harrington ,  Kate Ashton ,  Sean P. Brown ,  Matthew R. Kaller ,  Todd J. Kohn ,  Brian Alan Lanman ,  Kexue Li ,  Yunxiao Li ,  Jonathan D. Low ,  Ana Elena Minatti ,  Alexander J. Pickrell ,  Markian M. Stec ,  Joshua Taygerly

IPC分类号： A61K31/553 ,  A61P35/02 ,  A61P35/00 ,  C07D498/08

摘要： Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

公开(公告)号：US10532042B2

公开(公告)日：2020-01-14

申请号：US15849905

申请日：2017-12-21

申请人： AMGEN INC.

发明人： Brian Alan Lanman ,  Victor J. Cee ,  Alexander J. Pickrell ,  Anthony B. Reed ,  Kevin C. Yang ,  David John Kopecky ,  Hui-Ling Wang ,  Patricia Lopez ,  Kate Ashton ,  Shon Booker ,  Christopher M. Tegley

IPC分类号： C07D487/04 ,  A61K31/428 ,  A61K31/496 ,  A61K31/519 ,  A61P35/00 ,  A61K31/5025 ,  A61K31/502 ,  A61K31/517 ,  C07D401/04 ,  C07D403/04 ,  C07D239/80 ,  C07D417/04 ,  C07D471/04 ,  C07D471/08 ,  C07D487/10 ,  C07D275/04 ,  C07D513/04

摘要： Provided herein are KRAS G12C inhibitors, compounds of formula (II), or a pharmaceutically acceptable salt thereof: compositions of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.