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公开(公告)号：US20200337907A1
公开(公告)日：2020-10-29
申请号：US16759090
申请日：2018-10-30
发明人： Robert T. Fitzsimons, Jr. , Bryan A. Baker , Jana Ninkovic , Jie Liu , Federica Sgolastra , Minghua Dai , Wei Zhang , Amy K. McNulty
摘要： An article including: a network of interconnected polymeric strands; wherein each of the interconnected polymeric strands has a first surface adapted to contact a tissue site; wherein none of the interconnected polymeric strand has a feature extending from the first surface of the interconnected polymeric strands; wherein at least one of the interconnected polymeric strands is non-linear; and a plurality of openings between adjacent interconnected polymeric strands; wherein the article is a negative pressure wound therapy article
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公开(公告)号：US20220334108A1
公开(公告)日：2022-10-20
申请号：US17762945
申请日：2020-09-24
发明人： Frederica Sgolastra , Stephen B. Roscoe , Daniel M. Dohmeier , Masayuki Nakamura , Catherine A. Bothof , Deniz Yuksel Yurt , David D. Johnson , Kyle A. Kalstabakken , Minghua Dai , Myungchan Kang , Neil Percy , Leslie M. Horton , Stephen M. Kennedy
IPC分类号： G01N33/53 , G01N33/543 , G01N33/552 , G01N33/74 , C03C11/00 , C03C17/30
摘要： A composition and method of detecting an analyte in a sample using the composition, the composition including: a liquid that includes water; a plurality of first hollow glass bubbles in the liquid; a plurality of covalently attached first affinity groups that are covalently attached to at least some of the plurality of first hollow glass bubbles; and a plurality of first detector compound molecules not covalently bonded to the plurality of first hollow glass bubbles; wherein the first detector compound molecules include a first detectable group that is detected at a first wavelength; and wherein the first hollow glass bubbles have: a density of less than 0.60 gram/mole; a span of less than 1.0; and a plurality of covalently attached first affinity groups.
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公开(公告)号：US09987633B2
公开(公告)日：2018-06-05
申请号：US15309505
申请日：2015-06-08
发明人： Stephen B. Roscoe , Myungchan Kang , Evan D. Brutinel , Jesse D. Miller , Renee K. Cline , Minghua Dai , Hsi-Chou Liu
CPC分类号： B01L3/5029 , B01L3/502 , B01L2200/16 , B01L2300/0825 , B01L2400/0406 , B01L2400/0478 , G01N33/5304
摘要： Assay devices are provided including a receptacle having a sample entry port; a plunger disposed within the receptacle; at least one reagent; a membrane attached to a first surface of the plunger; a wick providing capillary force; and a detection zone. The membrane includes a target conjugate zone in which affinity components are disposed. Capture compounds are immobilized in a detection zone, which is located between the target conjugate zone and the wick. A method of detecting a target analyte is also provided, including providing the assay device; providing a sample suspected to contain a target analyte; adding the sample onto the device; allowing the sample to travel along the membrane until the sample reaches the detection zone; immobilizing the target analyte through reaction of the target analyte with the capture compounds; reacting the immobilized target analyte with a reagent to generate a detectable signal; and detecting the generated signal.
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公开(公告)号：US11034728B2
公开(公告)日：2021-06-15
申请号：US16339085
申请日：2017-09-28
发明人： Minghua Dai , Amy K. McNulty , Federica Sgolastra , Jie Liu , Jana Ninkovic , Robert T. Fitzsimons, Jr.
IPC分类号： C07K7/08
摘要： A polypeptide having a sequence at least 70% identical to SEQ ID NO: 1 (YVSPGMKNVNWWSHWWHATD) is provided. The polypeptide includes no more than 100 total amino acid residues.
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公开(公告)号：US20200368072A1
公开(公告)日：2020-11-26
申请号：US16770989
申请日：2018-12-12
发明人： Amy K. McNulty , Robert T. Fitzsimons , Kurt J. Halverson , Bryan A. Baker , Jana Ninkovic , Jie Liu , Minghua Dai , Wei Zhang , Kiu-Yuen Tse , David R. Holm , Graham M. Clarke , Federica Sgolastra
摘要： An article, including a network of interconnected polymeric strands; wherein each of the interconnected polymeric strands has a first surface adapted to contact a tissue site and a second surface opposite the first surface; wherein at least one of the interconnected polymeric stand has a plurality of features extending from the first surface of the interconnected polymeric strands; wherein at least one of the interconnected polymeric strands is non-linear; a plurality of openings between adjacent interconnected polymeric strands; an adhesive layer in contact with the second surface of the interconnected polymeric strands; and a filler in contact with the adhesive layer, the adhesive layer in between the network of interconnected polymeric strands and the filler; wherein the article is a negative pressure wound therapy article.
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公开(公告)号：US20190183685A1
公开(公告)日：2019-06-20
申请号：US16311508
申请日：2017-06-23
发明人： Amy K. McNulty , Robert T. Fitzsimons, Jr. , Kurt J. Halverson , Bryan A. Baker , Jana Ninkovic , Jie Liu , Minghua Dai , Wei Zhang , Federica Sgolastra
CPC分类号： A61F13/00068 , A61M1/0088 , A61M27/00
摘要： An article, including a network of interconnected polymeric strands; wherein each of the interconnected polymeric strands has a first surface adapted to contact a tissue site; wherein at least one of the interconnected polymeric strand has a plurality of features extending from the first surface of the interconnected polymeric strands; wherein at least one of the interconnected polymeric strands is non-linear; and a plurality of openings between adjacent polymeric strands; wherein the article is a negative pressure wound therapy article.
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公开(公告)号：US20180243737A1
公开(公告)日：2018-08-30
申请号：US15962391
申请日：2018-04-25
发明人： Stephen B. Roscoe , Myungchan Kang , Evan D. Brutinel , Jesse D. Miller , Renee K. Cline , Minghua Dai , Hsi-Chou Liu
CPC分类号： B01L3/5029 , B01L3/502 , B01L2200/16 , B01L2300/0825 , B01L2400/0406 , B01L2400/0478 , G01N33/5304
摘要： Assay devices are provided including a receptacle having a sample entry port; a plunger disposed within the receptacle; at least one reagent; a membrane attached to a first surface of the plunger; a wick providing capillary force; and a detection zone. The membrane includes a target conjugate zone in which affinity components are disposed. Capture compounds are immobilized in a detection zone, which is located between the target conjugate zone and the wick. A method of detecting a target analyte is also provided, including providing the assay device; providing a sample suspected to contain a target analyte; adding the sample onto the device; allowing the sample to travel along the membrane until the sample reaches the detection zone; immobilizing the target analyte through reaction of the target analyte with the capture compounds; reacting the immobilized target analyte with a reagent to generate a detectable signal; and detecting the generated signal.
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公开(公告)号：US11376164B2
公开(公告)日：2022-07-05
申请号：US16770989
申请日：2018-12-12
发明人： Amy K. McNulty , Robert T. Fitzsimons, Jr. , Kurt J. Halverson , Bryan A. Baker , Jana Ninkovic , Jie Liu , Minghua Dai , Wei Zhang , Kiu-Yuen Tse , David R. Holm , Graham M. Clarke , Federica Sgolastra
摘要： An article, including a network of interconnected polymeric strands; wherein each of the interconnected polymeric strands has a first surface adapted to contact a tissue site and a second surface opposite the first surface; wherein at least one of the interconnected polymeric stand has a plurality of features extending from the first surface of the interconnected polymeric strands; wherein at least one of the interconnected polymeric strands is non-linear; a plurality of openings between adjacent interconnected polymeric strands; an adhesive layer in contact with the second surface of the interconnected polymeric strands; and a filler in contact with the adhesive layer, the adhesive layer in between the network of interconnected polymeric strands and the filler; wherein the article is a negative pressure wound therapy article.
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公开(公告)号：US11254716B2
公开(公告)日：2022-02-22
申请号：US16339139
申请日：2017-10-02
发明人： Minghua Dai , Amy K. McNulty , Federica Sgolastra , Jie Liu , Jana Ninkovic , Robert T. Fitzsimons, Jr.
摘要： A polypeptide having a sequence at least 60% identical to SEQ ID NO: 1 (WFEWPYWEMNVPDVWN) is provided. The polypeptide includes no more than 100 total amino acid residues.
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公开(公告)号：US20200146892A1
公开(公告)日：2020-05-14
申请号：US16624785
申请日：2018-06-12
发明人： Amy K. McNulty , Robert T. Fitzsimons, Jr. , Kurt J. Halverson , Bryan A. Baker , Jana Ninkovic , Jie Liu , Minghua Dai , Wei Zhang , Graham M. Clarke , Federica Sgolastra
摘要： An article, including a network of interconnected polymeric strands; wherein each of the interconnected polymeric strands has a first surface adapted to contact a tissue site; wherein at least one of the interconnected polymeric strand has a plurality of features extending from the first surface of the interconnected polymeric strands; wherein only one of any two adjacent polymeric strands has a plurality of features extending from the first surface of the interconnected polymeric strands; and wherein at least one of the interconnected polymeric strands is non-linear; and a plurality of openings between adjacent interconnected polymeric strands.
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