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    Derivatives of the insulinotropic peptide exendin-4 and methods of production thereof
    3.
    发明授权
    Derivatives of the insulinotropic peptide exendin-4 and methods of production thereof 有权
    促胰岛素肽毒蜥外泌肽-4的衍生物及其生产方法

    公开(公告)号：US07329646B2

    公开(公告)日：2008-02-12

    申请号：US10704409

    申请日：2003-11-07

    Applicant: Yukun Sun ,  Dengxi Wu ,  Wen Chen ,  Zhiyong Zhu

    Inventor： Yukun Sun ,  Dengxi Wu ,  Wen Chen ,  Zhiyong Zhu

    IPC: A61K38/22 ,  C07K14/575

    CPC classification number: C07K14/575

    Abstract: The present invention is directed to the development of novel exendin-4 derivatives exhibiting advantageous glucose-regulatory properties, and to methods of producing these derivatives, including recombinant methods in which these derivatives are produced by cleavage of a fusion protein containing multiple copies of the exendin-4 derivative peptide. The methods of the present invention can be used to simplify the process of producing the disclosed exendin-4 derivatives, thereby lowering the cost of their production.

    Abstract translation: 本发明涉及显示出有利的葡萄糖调节性质的新型毒蜥外泌肽-4衍生物的开发，以及生产这些衍生物的方法，包括重组方法，其中通过裂解含有多拷贝的毒蜥外泌肽的融合蛋白来产生这些衍生物 -4衍生肽。 本发明的方法可以用于简化生成所公开的毒蜥外泌肽-4衍生物的方法，从而降低其生产成本。

    DERIVATIVES OF MAGAININ AND METHODS OF PRODUCTION THEREOF
    4.
    发明申请
    DERIVATIVES OF MAGAININ AND METHODS OF PRODUCTION THEREOF 审中-公开
    马丁的衍生物及其生产方法

    公开(公告)号：US20070166790A1

    公开(公告)日：2007-07-19

    申请号：US11686190

    申请日：2007-03-14

    Applicant: Yukun Sun ,  Dengxi Wu ,  Zhiyong Zhu

    Inventor： Yukun Sun ,  Dengxi Wu ,  Zhiyong Zhu

    IPC: C07K14/47 ,  A61K38/17 ,  C07H21/04 ,  C12P21/06

    CPC classification number: C07K14/463 ,  A61K38/00

    Abstract: The present invention provides a Magainin derivative peptide and method of production thereof. Also provided is a pharmaceutically composition comprising said Magainin derivative peptide and pharmaceutically acceptable carrier and/or pharmaceutically compatible binding agents. The Magainin derivative peptide of the present invention having amino acid sequence of the general formula shown as below: Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-X-Asn-Y-Z-OH in which: X is an amino acid residue selected from the group consisting of Met, Ile and Leu; Y is an amino acid residue selected from the group consisting of Ser, Lys, Ile, Arg and Leu; and Z is Arg.

    Abstract translation: 本发明提供了Magainin衍生肽及其制备方法。 还提供了包含所述Magainin衍生肽和药学上可接受的载体和/或药学上相容的结合剂的药物组合物。 具有如下通式的氨基酸序列的本发明的Magainin衍生肽：<？in-line-formula description =“In-line formula”end =“lead”→Gly-Ile-Gly-Lys- Phe-Leu-His-Ser-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-X-Asn-YZ-OH 其中：X为选自Met，Ile和Leu的氨基酸残基; Y是选自Ser，Lys，Ile，Arg和Leu的氨基酸残基; Z是Arg。

    Method of producing insulinotropic GLP-1 (7-36) polypeptide and/or GLP-1 analogs
    5.
    发明授权
    Method of producing insulinotropic GLP-1 (7-36) polypeptide and/or GLP-1 analogs 有权
    产生促胰岛素GLP-1（7-36）多肽和/或GLP-1类似物的方法

    公开(公告)号：US07544512B2

    公开(公告)日：2009-06-09

    申请号：US10761717

    申请日：2004-01-20

    Applicant: Yukun Sun ,  Dengxi Wu ,  Aizhen Wu ,  Zhiyong Zhu ,  Gang Yu ,  Jiaxiang Zhou ,  Shaoling Zhao

    Inventor： Yukun Sun ,  Dengxi Wu ,  Aizhen Wu ,  Zhiyong Zhu ,  Gang Yu ,  Jiaxiang Zhou ,  Shaoling Zhao

    IPC: A61K38/26 ,  C12N15/16 ,  A61K38/00

    CPC classification number: C07K14/605 ,  C07K2319/00

    Abstract: The present invention discloses a method of producing polypeptides, including insulinotropic GLP-1 (7-36) polypeptide and/or GLP-1 analogs, by ligating genes in a tandem way. Also disclosed are the recombinant polypeptides produced by such a method. Using the method of this invention, 1 to 32 copies of GLP-1 (7-36) and/or GLP-1 analog genes may be expressed in tandem and the desired polypeptide can be obtained after cleavage of a fusion protein and further processes of separation and purification thus making possible the production of recombinant polypeptides, including recombinant GLP-1 (7-36) and/or GLP-1 analogs on a large scale, at a significantly reduced production cost.

    Abstract translation: 本发明公开了通过以串联方式连接基因来产生包括促胰岛素GLP-1（7-36）多肽和/或GLP-1类似物的多肽的方法。 还公开了通过这种方法产生的重组多肽。 使用本发明的方法，可以串联表达1至32拷贝的GLP-1（7-36）和/或GLP-1类似物，并且可以在切割融合蛋白后获得所需的多肽， 分离和纯化，从而以显着降低的生产成本使得大规模生产重组多肽（包括重组GLP-1（7-36）和/或GLP-1类似物）成为可能。

    Derivatives of magainin and methods of production thereof
    6.
    发明授权
    Derivatives of magainin and methods of production thereof 有权
    magainin衍生物及其生产方法

    公开(公告)号：US07232800B2

    公开(公告)日：2007-06-19

    申请号：US10705106

    申请日：2003-11-10

    Applicant: Yukun Sun ,  Dengxi Wu ,  Zhiyong Zhu

    Inventor： Yukun Sun ,  Dengxi Wu ,  Zhiyong Zhu

    IPC: A61K38/17 ,  C12P21/02 ,  C07K14/46 ,  C07K14/435

    CPC classification number: C07K14/463 ,  A61K38/00

    Abstract: The present invention provides a Magainin derivative peptide and method of production thereof. Also provided is a pharmaceutically composition comprising said Magainin derivative peptide and pharmaceutically acceptable carrier and/or pharmaceutically compatible binding agents. The Magainin derivative peptide of the present invention having amino acid sequence of the general formula shown as below:      Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys- Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-X-Asn-Y-Z-OH in which: X is an amino acid residue selected from the group consisting of Met, Ile and Leu; Y is an amino acid residue selected from the group consisting of Ser, Lys, Ile, Arg and Leu; and Z is Arg.

    Abstract translation: 本发明提供了Magainin衍生肽及其制备方法。 还提供了包含所述Magainin衍生肽和药学上可接受的载体和/或药学上相容的结合剂的药物组合物。 具有如下通式的氨基酸序列的本发明的Magainin衍生肽：

    Gly-Ile-Gly-Lys-Phe-Leu-His-Ser Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-X-Asn-YZ-OH-Ala-Lys-Lys- 其中：X是选自Met，Ile和Leu的氨基酸残基; Y是选自Ser，Lys，Ile，Arg和Leu的氨基酸残基; Z是Arg。

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