Invention Grant
- Patent Title: Derivatives of magainin and methods of production thereof
- Patent Title (中): magainin衍生物及其生产方法
-
Application No.: US10705106Application Date: 2003-11-10
-
Publication No.: US07232800B2Publication Date: 2007-06-19
- Inventor: Yukun Sun , Dengxi Wu , Zhiyong Zhu
- Applicant: Yukun Sun , Dengxi Wu , Zhiyong Zhu
- Applicant Address: CN Shanghai
- Assignee: Shanghai Huayi Biotech Lab
- Current Assignee: Shanghai Huayi Biotech Lab
- Current Assignee Address: CN Shanghai
- Agency: Bell, Boyd & Lloyd LLP
- Priority: CN01112855 20010510
- Main IPC: A61K38/17
- IPC: A61K38/17 ; C12P21/02 ; C07K14/46 ; C07K14/435
Abstract:
The present invention provides a Magainin derivative peptide and method of production thereof. Also provided is a pharmaceutically composition comprising said Magainin derivative peptide and pharmaceutically acceptable carrier and/or pharmaceutically compatible binding agents. The Magainin derivative peptide of the present invention having amino acid sequence of the general formula shown as below: Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys- Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-X-Asn-Y-Z-OH in which: X is an amino acid residue selected from the group consisting of Met, Ile and Leu; Y is an amino acid residue selected from the group consisting of Ser, Lys, Ile, Arg and Leu; and Z is Arg.
Abstract(Chinese):
本发明提供了Magainin衍生肽及其制备方法。 还提供了包含所述Magainin衍生肽和药学上可接受的载体和/或药学上相容的结合剂的药物组合物。 具有如下通式的氨基酸序列的本发明的Magainin衍生肽：
