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17 条记录 (耗时 0.025 秒)

    Imidazopyridine derivatives for the treatment of hypertension
    1.
    发明授权
    Imidazopyridine derivatives for the treatment of hypertension 失效
    咪唑并吡啶衍生物用于治疗高血压

    公开(公告)号：US5424316A

    公开(公告)日：1995-06-13

    申请号：US058925

    申请日：1993-05-10

    申请人： Yasushi Honma ,  Yasuo Sekine ,  Sumihiro Nomura ,  Kazuaki Naito ,  Hiroshi Narita

    发明人： Yasushi Honma ,  Yasuo Sekine ,  Sumihiro Nomura ,  Kazuaki Naito ,  Hiroshi Narita

    IPC分类号： C07D471/04 ,  A61K31/44 ,  C07D471/14

    CPC分类号： C07D471/04

    摘要： An imidazopyridine derivative is disclosed of the formula [I]: ##STR1## wherein R.sup.1 is lower alkyl, R.sup.2 is hydrogen, lower alkylsulfonyl or a group of the formula ##STR2## where Z is oxygen or two hydrogen atoms, R.sup.0 is lower alkyl, lower alkoxy, phenyl, hydrogen, di(lower alkyl) amino or lower alkenyl, R.sup.3 is carboxyl or lower alkoxycarbonyl and Ring A is substituted phenyl, and pharmaceutically acceptable salts thereof that are useful in prophylaxis and treatment of hypertension.

    摘要翻译： 公开了式[I]的咪唑并吡啶衍生物：其中R 1是低级烷基，R 2是氢，低级烷基磺酰基或下式的基团其中Z是氧或两个氢原子，R 0是 低级烷基，低级烷氧基，苯基，氢，二（低级烷基）氨基或低级烯基，R3为羧基或低级烷氧基羰基，环A为取代苯基及其药学上可接受的盐，可用于预防和治疗高血压。

    Method and system for replacing program in uninterruptible computer system
    2.
    发明授权
    Method and system for replacing program in uninterruptible computer system 失效
    不间断电脑系统更换程序的方法和系统

    公开(公告)号：US5274808A

    公开(公告)日：1993-12-28

    申请号：US762452

    申请日：1991-09-19

    申请人： Takeshi Miyao ,  Tomoaki Nakamura ,  Hiroshi Wataya ,  Saburou Iijima ,  Yasuo Sekine

    发明人： Takeshi Miyao ,  Tomoaki Nakamura ,  Hiroshi Wataya ,  Saburou Iijima ,  Yasuo Sekine

    IPC分类号： G06F9/06 ,  G06F9/445 ,  G06F9/46

    CPC分类号： G06F8/67

    摘要： A program replacing method is provided for an uninterruptible online computer system. The computer system includes an auxiliary storage unit for storing a program currently running in the computer system and another program to replace the current running program and a replacement request managing table for storing replacement requests and program IDs of such replacing programs. These programs include checkpoints pre-programmed at selected locations therein. At an optional checkpoint, the replacement request managing table is retrieved for checking whether or not the replacement is requested. If a replacement is requested, the new program is started according to the program ID and the current program is terminated.

    摘要翻译： 为不间断的在线计算机系统提供了程序替换方法。 计算机系统包括用于存储当前运行在计算机系统中的程序的辅助存储单元和用于替换当前运行程序的另一程序以及用于存储替换程序的替换请求和程序ID的替换请求管理表。 这些程序包括在其中选定位置预编程的检查点。 在可选的检查点，检索替换请求管理表以检查是否请求替换。 如果请求更换，则根据程序ID启动新程序，当前程序终止。

    Pyrazolopyrimidine compound and a process for preparing the same
    4.
    发明授权
    Pyrazolopyrimidine compound and a process for preparing the same 失效
    吡唑并嘧啶化合物及其制备方法

    公开(公告)号：US07384952B2

    公开(公告)日：2008-06-10

    申请号：US10542081

    申请日：2004-01-23

    申请人： Iwao Takamuro ,  Yasuo Sekine ,  Yasunori Tsuboi ,  Kouji Nogi ,  Hiroyuki Taniguchi

    发明人： Iwao Takamuro ,  Yasuo Sekine ,  Yasunori Tsuboi ,  Kouji Nogi ,  Hiroyuki Taniguchi

    IPC分类号： C07D487/04 ,  C07D519/00 ,  A61K31/519

    CPC分类号： C07D487/04

    摘要： The present invention provides a novel pyrazolopyrimidine compound of the formula [I]: wherein R′ is (A) a substituted aryl group, (B) an optionally substituted nitrogen-containing aliphatic heteromonocyclic group, (C) a substituted cyclo-lower alkyl group, (D) an optionally substituted amino group, or (E) a substituted heteroaryl group, R2 is (a) an optionally substituted heteroaryl group or (b) an optionally substituted aryl group, Y is a single bond, a lower alkylene group or a lower alkenylene group, Z is a group of the formula: —CO—, —CH2-, —SO2- or a group of the formula [II]: Q is a lower alkylene group, and q is an integer of 0 or 1 or a pharmaceutically acceptable sait thereof, which has a small conductance potassium channel (SK channel) blocking activity and is useful as a medicament and a process for preparing the same

    摘要翻译： 本发明提供式[I]的新型吡唑并嘧啶化合物：其中R'为（A）取代芳基，（B）任选取代的含氮脂族杂单环基团，（C）取代的环低级烷基 ，（D）任选取代的氨基或（E）取代的杂芳基，R 2是（a）任选取代的杂芳基或（b）任选取代的芳基，Y是 单键，低级亚烷基或低级亚烯基，Z为下式基团：-CO - ， - CH 2 - ， - SO 2 - 或式[II]基团：Q为低级亚烷基， q是0或1的整数或其药学上可接受的sait，其具有小的电导钾通道（SK通道）阻断活性，并且可用作药物及其制备方法

    Imidazopyridine derivatives and process for preparing the same
    5.
    发明授权
    Imidazopyridine derivatives and process for preparing the same 失效
    咪唑并吡啶衍生物及其制备方法

    公开(公告)号：US5753672A

    公开(公告)日：1998-05-19

    申请号：US871540

    申请日：1997-06-09

    申请人： Yasuo Sekine ,  Eiji Kawanishi ,  Hiroshi Narita ,  Yoshihiro Hashimoto ,  Masakazu Mizobe

    发明人： Yasuo Sekine ,  Eiji Kawanishi ,  Hiroshi Narita ,  Yoshihiro Hashimoto ,  Masakazu Mizobe

    IPC分类号： C07D471/04 ,  A61K31/44

    CPC分类号： C07D471/04

    摘要： An imidazopyridine derivative of the formula �I!: ##STR1## wherein R.sup.1 is a lower alkyl group, R.sup.2 is a lower alkanoyl group, and R.sup.3 and R.sup.4 are each lower alkyl groups, or both combine at the end thereof to form an alkylene group having 3 to 6 carbon atoms, and a pharmaceutically acceptable salt thereof, said imidazopyridine derivatives have an excellent angiotensin II antagonistic activity and are useful for the prophylaxis or treatment of hypertension.

    摘要翻译： 式[I]的咪唑并吡啶衍生物：其中R1是低级烷基，R2是低级烷酰基，R3和R4各自是低级烷基，或两者在末端结合形成 具有3〜6个碳原子的亚烷基及其可药用盐，所述咪唑并吡啶衍生物具有优异的血管紧张素II拮抗活性，可用于预防或治疗高血压。

    Imidazopyridine derivatives
    7.
    发明授权
    Imidazopyridine derivatives 失效
    咪唑并吡啶衍生物

    公开(公告)号：US5510354A

    公开(公告)日：1996-04-23

    申请号：US405201

    申请日：1995-03-16

    申请人： Yasushi Honma ,  Yasuo Sekine ,  Sumihiro Nomura ,  Kazuaki Naito ,  Hiroshi Narita

    发明人： Yasushi Honma ,  Yasuo Sekine ,  Sumihiro Nomura ,  Kazuaki Naito ,  Hiroshi Narita

    IPC分类号： C07D471/04 ,  A61K31/44

    CPC分类号： C07D471/04

    摘要： An imidazopyridine derivative of formula I! is disclosed ##STR1## wherein R.sup.1 is lower alkyl, R.sup.2 is a group of the formula ##STR2## Z is oxygen, R.sup.0 is a pyridyl, furyl or thienyl group, R.sup.3 is carboxyl or lower alkoxycarbonyl, Ring A is tetrazoyl-substituted phenyl and pharmaceutically acceptable salts thereof, for use in the prophylaxis and treatment of hypertension.

    摘要翻译： 公开了式[I]的咪唑并吡啶衍生物，其中R 1是低级烷基，R 2是下式的基团：Z是氧，R 0是吡啶基，呋喃基或噻吩基，R 3是羧基或 低级烷氧基羰基，环A是四唑基取代的苯基及其药学上可接受的盐，用于预防和治疗高血压。

    1,4-dihydropyridine derivatives
    8.
    发明授权
    1,4-dihydropyridine derivatives 失效
    1,4-二氢吡啶衍生物

    公开(公告)号：US5286869A

    公开(公告)日：1994-02-15

    申请号：US492951

    申请日：1990-03-12

    申请人： Hiroshi Ikawa ,  Akiyoshi Kadoiri ,  Yasuo Sekine

    发明人： Hiroshi Ikawa ,  Akiyoshi Kadoiri ,  Yasuo Sekine

    IPC分类号： C07D401/12

    CPC分类号： C07D401/12

    摘要： 1,4-Dihydropyridine derivatives of formula: ##STR1## wherein Ar.sup.1 represents an aromatic hydrocarbon group or an aromatic heteromonocyclic or heterobicyclic group containing therein 1 to 3 atoms selected from the group consisting of oxygen, sulfur and nitrogen; R.sup.1 represents a hydrocarbon group which may have one or more substituents; A represents (i) a straight chain or branched chain unsaturated hydrocarbon group, (ii) a cyclic unsaturated hydrocarbon group, or (iii) a group selected from the group consisting of --R--O--N.dbd.CH--, --R--N.dbd.N--, --R--CH.dbd.N-- and --R--N.dbd.CH--, in which R is an alkylene group having 1 to 6 carbon atoms; B represents an alkylene or alkenylene group having 1 to 3 carbon atoms, which may have a substituent; Ar.sup.2 represents an aromatic hydrocarbon group or a heterocyclic group; Ar.sup.3 represents a heterocyclic group which may have one or more substituents; and n is 0 or 1, and the corresponding optical active 1,4-dihydropyridine derivatives, having an optically active cite as indicated by *, have both superior vasodilative and platelet aggregation inhibiting activities.

    摘要翻译： 其中Ar 1表示芳族烃基或含有选自氧，硫和氮的1至3个原子的芳族杂单环或杂双环基; R1表示可具有一个或多个取代基的烃基; A表示（i）直链或支链不饱和烃基，（ii）环状不饱和烃基，或（iii）选自-RON = CH-，-RN = N-，-R -CH = N-和-RN = CH-，其中R是具有1至6个碳原子的亚烷基; B表示可以具有取代基的碳原子数1〜3的亚烷基或亚烯基; Ar 2表示芳香族烃基或杂环基; Ar 3表示可以具有一个以上取代基的杂环基; 并且n为0或1，并且具有如*所示的光学活性引物的相应的光学活性1,4-二氢吡啶衍生物具有优异的血管扩张和血小板聚集抑制活性。

    Pyrazolopyrimidine compound and a process for preparing the same
    10.
    发明申请
    Pyrazolopyrimidine compound and a process for preparing the same 失效
    吡唑并嘧啶化合物及其制备方法

    公开(公告)号：US20060135525A1

    公开(公告)日：2006-06-22

    申请号：US10542081

    申请日：2004-01-23

    申请人： Iwao Takamuro ,  Yasuo Sekine ,  Yasunori Tsuboi ,  Kouji Nogi ,  Hiroyuki Taniguchi

    发明人： Iwao Takamuro ,  Yasuo Sekine ,  Yasunori Tsuboi ,  Kouji Nogi ,  Hiroyuki Taniguchi

    IPC分类号： A61K31/519 ,  C07D487/02

    CPC分类号： C07D487/04

    摘要： The present invention provides a novel pyrazolopyrimidine compound of the formula [I]: wherein R′ is (A) a substituted aryl group, (B) an optionally substituted nitrogen-containing aliphatic heteromonocyclic group, (C) a substituted cyclo-lower alkyl group, (D) an optionally substituted amino group, or (E) a substituted heteroaryl group, R2 is (a) an optionally substituted heteroaryl group or (b) an optionally substituted aryl group, Y is a single bond, a lower alkylene group or a lower alkenylene group, Z is a group of the formula: —CO—, —CH2-, S02- or a group of the formula [II]: Q is a lower alkylene group, and q is an integer of 0 or 1 or a pharmaceutically acceptable sait thereof, which has a small conductance potassium channel (SK channel) blocking activity and is useful as a medicament and a process for preparing the same.

    摘要翻译： 本发明提供式[I]的新型吡唑并嘧啶化合物：其中R'为（A）取代芳基，（B）任选取代的含氮脂族杂单环基团，（C）取代的环低级烷基 ，（D）任选取代的氨基或（E）取代的杂芳基，R 2是（a）任选取代的杂芳基或（b）任选取代的芳基，Y是 单键，低级亚烷基或低级亚烯基，Z为下式基团：-CO-，-CH 2 - ，SO 2 - 或式[II]基团：Q为低级亚烷基，q为 是0或1的整数或其药学上可接受的sait，其具有小的电导钾通道（SK通道）阻断活性，并且可用作药物及其制备方法。