公开(公告)号：US4975460A

公开(公告)日：1990-12-04

申请号：US311854

申请日：1989-02-17

申请人： Takeo Iwakuma ,  Harumichi Kohno ,  Yasuhiko Sasaki ,  Katsuo Ikezawa ,  Akio Odawara

发明人： Takeo Iwakuma ,  Harumichi Kohno ,  Yasuhiko Sasaki ,  Katsuo Ikezawa ,  Akio Odawara

IPC分类号： A61K31/19 ,  A61K31/195 ,  A61K31/22 ,  A61K31/38 ,  A61K31/381 ,  A61P7/02 ,  C07C311/07 ,  C07C311/20 ,  C07D333/34

CPC分类号： C07C311/07 ,  C07C311/20 ,  C07C2102/08

摘要： Novel indanoxyacetic acid derivatives of the formula: ##STR1## wherein R.sup.1 is a lower alkyl group, a substituted or unsubstituted phenyl group, naphtyl group or a sulfur-containing heterocyclic group, R.sup.2 is hydroxy group or a protected hydroxy group, p is an integer of 2 or 3, and q is an integer of 0 or 1, and a salt thereof are disclosed.Said derivative (I) and a salt thereof are useful as a platelet aggregation-inhibiting agent and an agent for the treatment, amelioration and/or prophylaxis of a variety of thrombosis, embolism, coronary and cerebral vascular smooth muscl vellication, asthma, and the like.

公开(公告)号：US5387581A

公开(公告)日：1995-02-07

申请号：US35895

申请日：1993-03-23

申请人： Akio Odawara ,  Yasuhiko Sasaki ,  Sakae Murata ,  Hiroshi Narita

发明人： Akio Odawara ,  Yasuhiko Sasaki ,  Sakae Murata ,  Hiroshi Narita

IPC分类号： A61K31/52 ,  A61K31/55 ,  A61K31/60

CPC分类号： A61K31/60

摘要： There is disclosed a pharmaceutical composition for inhibiting the platelet aggregation comprising acetylsalicyclic acid or a pharmaceutically acceptable salt thereof and a 1,5-benzothiazepine derivative of the formula: ##STR1## wherein R.sup.1 is a lower alkyl group or a lower alkoxy group, R.sup.2 is hydrogen atom or a lower alkanoyl group, R.sup.3 is a lower alkyl group, R.sup.4 is hydrogen atom or a lower alkyl group and R.sup.5 is a lower alkyl group or a halogen atom, or a pharmaceutically acceptable salt thereof.

摘要翻译： 公开了一种用于抑制血小板聚集的药物组合物，其包含乙酰水杨酸或其药学上可接受的盐和下式的1,5-苯并硫氮杂衍生物：其中R 1是低级烷基或低级烷氧基 R2为氢原子或低级烷酰基，R3为低级烷基，R4为氢原子或低级烷基，R5为低级烷基或卤原子，或其药学上可接受的盐。

公开(公告)号：US5206428A

公开(公告)日：1993-04-27

申请号：US605433

申请日：1990-10-30

申请人： Hideo Nakai ,  Toyoharu Yamashita ,  Harumichi Kohno ,  Yasuhiko Sasaki ,  Akio Odawara

发明人： Hideo Nakai ,  Toyoharu Yamashita ,  Harumichi Kohno ,  Yasuhiko Sasaki ,  Akio Odawara

IPC分类号： A61K31/18 ,  A61K31/33 ,  A61K31/44 ,  A61K31/4406 ,  A61P7/02 ,  C07C311/07 ,  C07C311/14 ,  C07C311/20 ,  C07C311/29 ,  C07D213/71 ,  C07D333/34 ,  C07D521/00

CPC分类号： C07C311/29 ,  C07C311/07 ,  C07C311/14 ,  C07C311/20 ,  C07D213/71 ,  C07D333/34 ,  C07C2102/10

摘要： A tetrahydronaphthalene derivative of the formula: ##STR1## wherein R.sup.1 is a substituted or unsubstituted phenyl group, naphthyl group, a sulfur- or nitrogen-containing heterocyclic group, a lower alkyl group or cycloalkyl group, and R.sup.2 is hydroxymethyl group, carboxyl group, a lower alkoxycarbonyl group or a group of the formula: ##STR2## wherein R.sup.3 is hydrogen atom or a lower alkyl group, R.sup.4 is a lower alkoxycarbonyl-phenyl group, carboxy-phenyl group, a lower alkyl group, a lower alkoxycarbonyl-lower alkyl group or carboxy-lower alkyl group, and m and n are different and are 1 or 2, or a pharmaceutically acceptable salt thereof, which are useful as a platelet aggregation-inhibiting agent and as an agent for the treatment, amelioration and/or prophylaxis of a variety of thrombosis or embolism, coronary and cerebral vascular smooth muscle vellication, asthma, and the like, processes for the preparation thereof, and pharmaceutical composition containing said compound as an active ingredient.

公开(公告)号：US4963587A

公开(公告)日：1990-10-16

申请号：US446106

申请日：1989-12-05

申请人： Takeo Iwakuma ,  Yasuo Sekine ,  Yasuhiko Sasaki ,  Katsuo Ikezawa ,  Akio Odawara

发明人： Takeo Iwakuma ,  Yasuo Sekine ,  Yasuhiko Sasaki ,  Katsuo Ikezawa ,  Akio Odawara

IPC分类号： A61K31/195 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00 ,  C07C303/38 ,  C07C311/20

CPC分类号： C07C311/20 ,  C07C2102/08 ,  Y02P20/55

摘要： There are disclosed are glycine derivative of the formula: ##STR1## (wherein R.sup.1 represents a substituted or unsubstituted phenyl group, R.sup.2 represents a carboxyl group which may be protected, Q represents a lower alkylene group and m represents 0 or 1) or a pharmacologically acceptable salt thereof and a process for preparing the same.

公开(公告)号：US5382577A

公开(公告)日：1995-01-17

申请号：US14233

申请日：1993-02-05

申请人： Akio Odawara ,  Yasuhiko Sasaki ,  Sakae Murata ,  Hiroshi Narita

发明人： Akio Odawara ,  Yasuhiko Sasaki ,  Sakae Murata ,  Hiroshi Narita

IPC分类号： A61K31/435 ,  A61K31/55 ,  A61K31/554 ,  A61P7/02 ,  C07D281/10 ,  A61K31/44

CPC分类号： A61K31/55

摘要： There is disclosed a pharmaceutical composition for inhibiting platelet aggregation comprising 5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine or a pharmaceutically acceptable salt thereof and a 1,5-benzothiazepine derivative of the formula: ##STR1## wherein R.sup.1 is a lower alkyl group or a lower alkoxy group, R.sup.2 is a lower alkanoyl group, R.sup.3 and R.sup.4 are a lower alkyl group and R.sup.5 is hydrogen atom, a lower alkyl group or a halogen atom, or a pharmaceutically acceptable salt thereof.

摘要翻译： 公开了一种用于抑制血小板聚集的药物组合物，其包含5-（2-氯苄基）-4,5,6,7-四氢噻吩并[3,2-c]吡啶或其药学上可接受的盐和1,5-苯并硫氮杂衍生物 式（I）其中R1是低级烷基或低级烷氧基，R2是低级烷酰基，R3和R4是低级烷基，R5是氢原子，低级烷基或 卤素原子或其药学上可接受的盐。

公开(公告)号：US5206418A

公开(公告)日：1993-04-27

申请号：US850882

申请日：1992-03-13

申请人： Hideo Nakai ,  Toyoharu Yamashita ,  Harumichi Kohno ,  Yasuhiko Sasaki ,  Akio Odawara

发明人： Hideo Nakai ,  Toyoharu Yamashita ,  Harumichi Kohno ,  Yasuhiko Sasaki ,  Akio Odawara

IPC分类号： C07C311/07 ,  C07C311/14 ,  C07C311/20 ,  C07C311/29 ,  C07D213/71 ,  C07D333/34

CPC分类号： C07C311/07 ,  C07C311/14 ,  C07C311/20 ,  C07C311/29 ,  C07D213/71 ,  C07D333/34 ,  C07C2102/10

摘要： The invention relates to aminotetrahydronaphthalene derivatives which are intermediates for the preparation of sulfonylaminotetrahydronaphthalenes.

摘要翻译： 本发明涉及作为制备磺酰氨基四氢萘的中间体的氨基四氢萘衍生物。

公开(公告)号：US5190975A

公开(公告)日：1993-03-02

申请号：US897412

申请日：1992-06-12

申请人： Takeo Iwakuma ,  Harumichi Kohno ,  Yasuhiko Sasaki ,  Katsuo Ikezawa ,  Akio Odawara

发明人： Takeo Iwakuma ,  Harumichi Kohno ,  Yasuhiko Sasaki ,  Katsuo Ikezawa ,  Akio Odawara

IPC分类号： C07C233/52 ,  C07C311/20 ,  C07C311/29 ,  C07D257/06 ,  C07D333/34 ,  C07D333/36

CPC分类号： C07D333/36 ,  C07C233/52 ,  C07C311/20 ,  C07C311/29 ,  C07D257/06 ,  C07D333/34 ,  C07C2101/14 ,  C07C2102/08

摘要： Method for the treatment or prophylaxis of thromboses or asthma in warm-blooded animal which comprises administering an effective amount of a compound having the formula: ##STR1## wherein R.sup.1 is phenyl group or phenyl group substituted by a member selected from the group consisting of C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, halogen atom, trifluoromethyl, and nitro, or naphthyl group, and R.sup.2 is hydroxymethyl or a group of the formula: ##STR2## wherein R.sup.3 is hydrogen atom or C.sub.1 -C.sub.5 alkyl and R.sup.4 is C.sub.3 -C.sub.6 cycloalkyl, C.sub.2 -C.sub.6 alkoxycarbonyl-phenyl, carboxy-phenyl, C.sub.1 -C.sub.5 alkyl, or C.sub.1 -C.sub.5 alkyl having a substituent selected from C.sub.1 -C.sub.5 alkoxycarbonyl, carboxy, C.sub.2 -C.sub.6 alkoxycarbonyl-phenyl, carboxy-phenyl, C.sub.2 -C.sub.6 alkoxycarbonyl-(C.sub.3 -C.sub.6) cycloalkyl and carboxy-(C.sub.3 -C.sub.6) cycloalkyl, or a pharmaceutically acceptable salt thereof to said warm blooded animal.

摘要翻译： 用于治疗或预防温血动物血栓形成或哮喘的方法，其包括给予有效量的具有下式的化合物：其中R 1是苯基或被选自C1的成员所取代的苯基 -C 5烷基，C 1 -C 5烷氧基，卤素原子，三氟甲基，硝基或萘基，R 2是羟甲基或下式的基团：其中R 3是氢原子或C 1 -C 5烷基， C 6环烷基，C 2 -C 6烷氧基羰基 - 苯基，羧基 - 苯基，C 1 -C 5烷基或具有选自C 1 -C 5烷氧基羰基，羧基，C 2 -C 6烷氧基羰基 - 苯基，羧基 - 苯基，C 2 -C 6 烷氧基羰基 - （C 3 -C 6）环烷基和羧基 - （C 3 -C 6）环烷基或其药学上可接受的盐。

公开(公告)号：US5030652A

公开(公告)日：1991-07-09

申请号：US271324

申请日：1988-11-15

申请人： Takeo Iwakuma ,  Harumichi Kohno ,  Yasuhiko Sasaki ,  Katsuo Ikezawa ,  Akio Odawara

发明人： Takeo Iwakuma ,  Harumichi Kohno ,  Yasuhiko Sasaki ,  Katsuo Ikezawa ,  Akio Odawara

IPC分类号： C07C233/52 ,  C07C311/20 ,  C07C311/29 ,  C07D257/06 ,  C07D333/34 ,  C07D333/36

CPC分类号： C07D333/36 ,  C07C233/52 ,  C07C311/20 ,  C07C311/29 ,  C07D257/06 ,  C07D333/34 ,  C07C2101/14 ,  C07C2102/08

摘要： Indan derivatives of the formula: ##STR1## wherein R.sup.1 is substituted or unsubstituted phenyl, naphthyl or sulfur-containing heterocyclic group, and R.sup.2 is hydroxy-methyl or a group of the formula: ##STR2## wherein R.sup.3 is hydrogen atom or lower alkyl and R.sup.4 is cycloalkyl, lower alkoxycarbonyl-phenyl, carboxy-phenyl, nitrogen-containing heterocyclic group, lower alkyl, or lower alkyl having a substituent selected from lower alkoxycarbonyl, carboxy, lower alkoxycarbonyl-phenyl, carboxy-phenyl, lower alkoxycarbonyl-cycloalkyl and carboxy-cycloalkyl, or a pharmaceutically acceptable salt thereof, which are useful as a platelet aggregation-inhibiting agent and as an agent for the treatment, amelioration and/or prophylaxis of a variety of thrombosis or embolism, coronary and cerebral vascular smooth muscle vellication, asthma, and the like, processes for the preparation thereof, and pharmaceutical composition containing said compound as an active ingredient.