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    Pyrazolopyrimidine compound and a process for preparing the same
    1.
    发明授权
    Pyrazolopyrimidine compound and a process for preparing the same 失效
    吡唑并嘧啶化合物及其制备方法

    公开(公告)号：US07384952B2

    公开(公告)日：2008-06-10

    申请号：US10542081

    申请日：2004-01-23

    申请人： Iwao Takamuro ,  Yasuo Sekine ,  Yasunori Tsuboi ,  Kouji Nogi ,  Hiroyuki Taniguchi

    发明人： Iwao Takamuro ,  Yasuo Sekine ,  Yasunori Tsuboi ,  Kouji Nogi ,  Hiroyuki Taniguchi

    IPC分类号： C07D487/04 ,  C07D519/00 ,  A61K31/519

    CPC分类号： C07D487/04

    摘要： The present invention provides a novel pyrazolopyrimidine compound of the formula [I]: wherein R′ is (A) a substituted aryl group, (B) an optionally substituted nitrogen-containing aliphatic heteromonocyclic group, (C) a substituted cyclo-lower alkyl group, (D) an optionally substituted amino group, or (E) a substituted heteroaryl group, R2 is (a) an optionally substituted heteroaryl group or (b) an optionally substituted aryl group, Y is a single bond, a lower alkylene group or a lower alkenylene group, Z is a group of the formula: —CO—, —CH2-, —SO2- or a group of the formula [II]: Q is a lower alkylene group, and q is an integer of 0 or 1 or a pharmaceutically acceptable sait thereof, which has a small conductance potassium channel (SK channel) blocking activity and is useful as a medicament and a process for preparing the same

    摘要翻译： 本发明提供式[I]的新型吡唑并嘧啶化合物：其中R'为（A）取代芳基，（B）任选取代的含氮脂族杂单环基团，（C）取代的环低级烷基 ，（D）任选取代的氨基或（E）取代的杂芳基，R 2是（a）任选取代的杂芳基或（b）任选取代的芳基，Y是 单键，低级亚烷基或低级亚烯基，Z为下式基团：-CO - ， - CH 2 - ， - SO 2 - 或式[II]基团：Q为低级亚烷基， q是0或1的整数或其药学上可接受的sait，其具有小的电导钾通道（SK通道）阻断活性，并且可用作药物及其制备方法

    Pyrazolopyrimidine compound and a process for preparing the same
    2.
    发明申请
    Pyrazolopyrimidine compound and a process for preparing the same 失效
    吡唑并嘧啶化合物及其制备方法

    公开(公告)号：US20060135525A1

    公开(公告)日：2006-06-22

    申请号：US10542081

    申请日：2004-01-23

    申请人： Iwao Takamuro ,  Yasuo Sekine ,  Yasunori Tsuboi ,  Kouji Nogi ,  Hiroyuki Taniguchi

    发明人： Iwao Takamuro ,  Yasuo Sekine ,  Yasunori Tsuboi ,  Kouji Nogi ,  Hiroyuki Taniguchi

    IPC分类号： A61K31/519 ,  C07D487/02

    CPC分类号： C07D487/04

    摘要： The present invention provides a novel pyrazolopyrimidine compound of the formula [I]: wherein R′ is (A) a substituted aryl group, (B) an optionally substituted nitrogen-containing aliphatic heteromonocyclic group, (C) a substituted cyclo-lower alkyl group, (D) an optionally substituted amino group, or (E) a substituted heteroaryl group, R2 is (a) an optionally substituted heteroaryl group or (b) an optionally substituted aryl group, Y is a single bond, a lower alkylene group or a lower alkenylene group, Z is a group of the formula: —CO—, —CH2-, S02- or a group of the formula [II]: Q is a lower alkylene group, and q is an integer of 0 or 1 or a pharmaceutically acceptable sait thereof, which has a small conductance potassium channel (SK channel) blocking activity and is useful as a medicament and a process for preparing the same.

    摘要翻译： 本发明提供式[I]的新型吡唑并嘧啶化合物：其中R'为（A）取代芳基，（B）任选取代的含氮脂族杂单环基团，（C）取代的环低级烷基 ，（D）任选取代的氨基或（E）取代的杂芳基，R 2是（a）任选取代的杂芳基或（b）任选取代的芳基，Y是 单键，低级亚烷基或低级亚烯基，Z为下式基团：-CO-，-CH 2 - ，SO 2 - 或式[II]基团：Q为低级亚烷基，q为 是0或1的整数或其药学上可接受的sait，其具有小的电导钾通道（SK通道）阻断活性，并且可用作药物及其制备方法。