公开(公告)号：US09144756B2

公开(公告)日：2015-09-29

申请号：US13111882

申请日：2011-05-19

申请人： Xiaodong Liu ,  Jinhua Chen ,  Christopher A. Pohl

发明人： Xiaodong Liu ,  Jinhua Chen ,  Christopher A. Pohl

IPC分类号： B01D15/32 ,  B01J20/287 ,  B01J20/32 ,  B01J20/289

CPC分类号： B01D15/327 ,  B01J20/287 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3219 ,  B01J20/3259 ,  B01J20/3263 ,  B01J20/3265 ,  B01J2220/82

摘要： The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC) and solid-phase extraction (SPE). The compositions provide both strong aromatic and hydrophobic interactions with components of a sample. Moreover, the invention provides compositions of new silanes, their immobilization on a solid substrate, such as silica, to form new stationary phases.

摘要翻译： 本发明提供了用于各种色谱应用的固定相的组合物，例如高效液相色谱（HPLC）和固相萃取（SPE）。 该组合物与样品的组分提供强烈的芳族和疏水相互作用。 此外，本发明提供新的硅烷的组合物，它们固定在固体基质如二氧化硅上以形成新的固定相。

公开(公告)号：US20140228347A1

公开(公告)日：2014-08-14

申请号：US14258963

申请日：2014-04-22

申请人： Valentina MOLTENI ,  Hank Michael James PETRASSI ,  Xiaolin LI ,  Xiaodong LIU ,  Jon LOREN ,  Juliet NABAKKA ,  Bao NGUYEN ,  Vince YEH

发明人： Valentina MOLTENI ,  Hank Michael James PETRASSI ,  Xiaolin LI ,  Xiaodong LIU ,  Jon LOREN ,  Juliet NABAKKA ,  Bao NGUYEN ,  Vince YEH

IPC分类号： C07D498/04 ,  C07D491/044 ,  C07D491/107 ,  C07D471/04

CPC分类号： C07D491/107 ,  C07D471/04 ,  C07D491/044 ,  C07D491/048 ,  C07D498/04

摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.

摘要翻译： 本发明提供了可用作蛋白激酶抑制剂的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调激酶活性相关的病症的方法。 在一些实施方案中，本发明提供了使用这些化合物治疗，改善或预防涉及c-kit或c-kit和PDGFR（PDGFRα，PDGFR＆bgr））激酶的异常活化的疾病或病症的方法。

公开(公告)号：US08795118B2

公开(公告)日：2014-08-05

申请号：US13409388

申请日：2012-03-01

申请人： Laszlo Hideg ,  Zhenxing Fu ,  Xiaodong Liu ,  Dumitru Puiu

发明人： Laszlo Hideg ,  Zhenxing Fu ,  Xiaodong Liu ,  Dumitru Puiu

IPC分类号： F16H3/72 ,  F16H31/00

CPC分类号： F16H61/0028 ,  B60K6/445 ,  F16H57/0439 ,  F16H2312/14 ,  Y02T10/6239

摘要： A method for assisting a transmission oil pump in a hybrid electric powertrain to generate transmission oil pressure rapidly during vehicle start. An electric motor is initially utilized to provide momentary torque to rotate an oil pump and rapidly generate transmission oil pressure. After initial assistance is provided by the electric motor, an oil pump electric motor powers the oil pump and maintains oil pressure within the hybrid powertrain.

摘要翻译： 一种用于在混合动力传动系中辅助变速器油泵以在车辆启动期间快速产生变速器油压的方法。 最初使用电动马达来提供瞬时扭矩来旋转油泵并快速产生变速器油压。 在由电动机提供初始帮助之后，油泵电动机为油泵供电并保持混合动力系统内的油压。

公开(公告)号：US20140178912A1

公开(公告)日：2014-06-26

申请号：US13724178

申请日：2012-12-21

申请人： Xiaodong LIU ,  Udayanath AICH ,  Christopher A. POHL

发明人： Xiaodong LIU ,  Udayanath AICH ,  Christopher A. POHL

IPC分类号： C08B37/00 ,  B01J43/00 ,  B01J41/20

CPC分类号： C08B37/0063 ,  B01D15/3847 ,  B01J20/286 ,  B01J20/3285 ,  B01J41/20 ,  B01J43/00 ,  B01J2220/54 ,  C07K1/165 ,  G01N30/482 ,  B01D15/363 ,  B01D15/305 ,  B01D15/325 ,  B01D15/362

摘要： An exemplary multimodal chromatographic medium of the invention includes one or more strong anion exchange, weak anion exchange, strong cation exchange and/or weak cation exchange binding sites in combination with one or more reverse phase and/or hydrophilic interaction chromatography binding site. In an exemplary embodiment, the sites interact with one or more glycans in a mixture of glycans in a manner that allows separation of glycans in the mixture and analysis of the glycan mixture. The media are incorporated into devices and systems for chromatographic analysis. Also provided are methods of using the multimodal media of the invention to analyze glycans.

摘要翻译： 本发明的示例性多峰色谱介质包含与一个或多个反相和/或亲水相互作用色谱结合位点结合的一个或多个强阴离子交换，弱阴离子交换，强阳离子交换和/或弱阳离子交换结合位点。 在一个示例性实施方案中，所述位点以聚糖混合物中的一种或多种聚糖与允许混合物中聚糖分离和聚糖混合物分析的方式相互作用。 将介质并入用于色谱分析的装置和系统中。 还提供了使用本发明的多峰介质来分析聚糖的方法。

公开(公告)号：US20140031333A1

公开(公告)日：2014-01-30

申请号：US14031792

申请日：2013-09-19

申请人： Valentina MOLENTI ,  Hank Michael James Petrassi ,  Xiaolin Li ,  Xiaodong Liu ,  Jon Loren ,  Juliet Nabakka ,  Bao Nguyen ,  Vince Yeh

发明人： Valentina MOLENTI ,  Hank Michael James Petrassi ,  Xiaolin Li ,  Xiaodong Liu ,  Jon Loren ,  Juliet Nabakka ,  Bao Nguyen ,  Vince Yeh

IPC分类号： C07D471/04 ,  C07D498/04 ,  C07D491/048

CPC分类号： C07D491/107 ,  C07D471/04 ,  C07D491/044 ,  C07D491/048 ,  C07D498/04

摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.

摘要翻译： 本发明提供了可用作蛋白激酶抑制剂的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调激酶活性相关的病症的方法。 在一些实施方案中，本发明提供了使用这些化合物治疗，改善或预防涉及c-kit或c-kit和PDGFR（PDGFRα，PDGFRβ）激酶异常活化的疾病或病症的方法。

公开(公告)号：US20130059846A1

公开(公告)日：2013-03-07

申请号：US13595575

申请日：2012-08-27

申请人： Vince YEH ,  Xiaolin LI ,  Xiaodong LIU ,  Jon LOREN ,  Valentina MOLTENI ,  Juliet NABAKKA ,  Bao NGUYEN ,  Hank Michael James PETRASSI

发明人： Vince YEH ,  Xiaolin LI ,  Xiaodong LIU ,  Jon LOREN ,  Valentina MOLTENI ,  Juliet NABAKKA ,  Bao NGUYEN ,  Hank Michael James PETRASSI

IPC分类号： A61K31/437 ,  A61K31/496 ,  A61K31/5377 ,  A61P19/04 ,  A61P11/00 ,  A61P1/00 ,  A61P37/06 ,  A61P3/00 ,  A61P21/00 ,  A61P17/00 ,  A61P9/12 ,  A61P11/06 ,  A61P37/08 ,  A61P9/00 ,  A61P3/10 ,  C07D471/04

CPC分类号： C07D471/04

摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.

公开(公告)号：US20130059832A1

公开(公告)日：2013-03-07

申请号：US13598213

申请日：2012-08-29

申请人： Valentina MOLTENI ,  Hank Michael James PETRASSI ,  Xiaolin LI ,  Xiaodong LIU ,  Jon LOREN ,  Juliet NABAKKA ,  Bao NGUYEN ,  Vince YEH

发明人： Valentina MOLTENI ,  Hank Michael James PETRASSI ,  Xiaolin LI ,  Xiaodong LIU ,  Jon LOREN ,  Juliet NABAKKA ,  Bao NGUYEN ,  Vince YEH

IPC分类号： A61K31/437 ,  C07D491/048 ,  A61K31/4545 ,  A61K31/5377 ,  C07D491/107 ,  A61K31/496 ,  A61P11/00 ,  A61P29/00 ,  A61P1/00 ,  A61P3/00 ,  A61P37/00 ,  A61P17/00 ,  A61P9/12 ,  A61P11/06 ,  A61P11/02 ,  A61P37/08 ,  A61P3/10 ,  A61P7/00 ,  A61P1/16 ,  C07D471/04

CPC分类号： C07D491/107 ,  C07D471/04 ,  C07D491/044 ,  C07D491/048 ,  C07D498/04

摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.

公开(公告)号：US20120275930A1

公开(公告)日：2012-11-01

申请号：US13409388

申请日：2012-03-01

申请人： Laszlo Hideg ,  Zhenxing Fu ,  Xiaodong Liu ,  Dumitru Puiu

发明人： Laszlo Hideg ,  Zhenxing Fu ,  Xiaodong Liu ,  Dumitru Puiu

IPC分类号： F04D13/06

CPC分类号： F16H61/0028 ,  B60K6/445 ,  F16H57/0439 ,  F16H2312/14 ,  Y02T10/6239

摘要： A method for assisting a transmission oil pump in a hybrid electric powertrain to generate transmission oil pressure rapidly during vehicle start. An electric motor is initially utilized to provide momentary torque to rotate an oil pump and rapidly generate transmission oil pressure. After initial assistance is provided by the electric motor, an oil pump electric motor powers the oil pump and maintains oil pressure within the hybrid powertrain.

摘要翻译： 一种用于在混合动力传动系中辅助变速器油泵以在车辆启动期间快速产生变速器油压的方法。 最初使用电动马达来提供瞬时扭矩来旋转油泵并快速产生变速器油压。 在由电动机提供初始帮助之后，油泵电动机为油泵供电并保持混合动力系统内的油压。

公开(公告)号：US08278452B2

公开(公告)日：2012-10-02

申请号：US12918801

申请日：2009-02-20

申请人： Donatella Chianelli ,  Xiaolin Li ,  Xiaodong Liu ,  Jon Loren ,  Valentina Molteni ,  Juliet Nabakka ,  Vince Yeh

发明人： Donatella Chianelli ,  Xiaolin Li ,  Xiaodong Liu ,  Jon Loren ,  Valentina Molteni ,  Juliet Nabakka ,  Vince Yeh

IPC分类号： C07D471/02

CPC分类号： C07D471/04

摘要： The invention provides a novel class of compounds of Formula I: (I) pharmaceutical compositions comprising such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of c-kit, PDGFRα and PDGFRβ kinases.

摘要翻译： 本发明提供了一类新颖的式I化合物：（I）包含这些化合物的药物组合物，用于治疗或预防与异常或失调的激酶活性相关的疾病或病症，特别是涉及c-kit，PDGFRα异常活化的疾病或病症，以及 PDGFR＆bgr 激酶。

公开(公告)号：US20120215933A1

公开(公告)日：2012-08-23

申请号：US13504233

申请日：2010-08-10

申请人： Xiaodong Liu

发明人： Xiaodong Liu

IPC分类号： G06F15/16

CPC分类号： H04L49/3009 ,  H04L12/4633 ,  H04L45/54 ,  H04L49/602 ,  H04L69/167 ,  H04L2212/00

摘要： A method and switch for realizing dynamic tunnel message forwarding are disclosed; the method includes: presetting an aggregation routing table item of a dynamic tunnel in an ASIC hardware forwarding table of a layer-3 switch located at the edge of the IPv6 network to point to the CPU; after receiving an IPv6 message, if the switch judges that the message points to the dynamic tunnel according to IPv6 route lookup, sending the message upward to the CPU according to the aggregation routing table item; after receiving the message, the CPU, by using a software routing mode, storing a corresponding relation between acquired layer-2 information and a network prefix of an IPv6 destination address of the message and synchronizing the corresponding relation to the ASIC hardware forwarding table, and forwarding the message out from an output port to which the layer-2 information corresponds.

摘要翻译： 公开了实现动态隧道消息转发的方法和转换; 该方法包括：在位于IPv6网络边缘的三层交换机的ASIC硬件转发表中预先设置动态隧道的聚合路由表项，以指向CPU; 收到IPv6报文后，如果交换机根据IPv6路由查找判断消息指向动态隧道，则根据聚合路由表项向上发送消息; 在接收到该消息之后，CPU通过使用软件路由模式来存储所获取的层2信息和消息的IPv6目的地地址的网络前缀之间的对应关系，并将对应关系与ASIC硬件转发表同步，以及 从第二层信息对应的输出端口转发消息。