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公开(公告)号：US07785879B1
公开(公告)日：2010-08-31
申请号：US11522698
申请日：2006-09-18
申请人： Wenyan Wang , Shahriar Shane Taremi , Winifred W. Prosise , Paul Reichert , Charles A. Lesburg , Vincent S. Madison , Kuo-Chi Cheng
发明人： Wenyan Wang , Shahriar Shane Taremi , Winifred W. Prosise , Paul Reichert , Charles A. Lesburg , Vincent S. Madison , Kuo-Chi Cheng
CPC分类号： C07K14/70567 , C07K14/4705 , C07K2319/31
摘要： The present invention relates, inter alia, to PXR polypeptides and crystals that are useful, for example, for crystallization and in assays for identification of modulators of PXR.
摘要翻译： 本发明尤其涉及PXR多肽和晶体，其可用于例如结晶和用于鉴定PXR调节剂的测定。
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公开(公告)号：US11014986B2
公开(公告)日：2021-05-25
申请号：US15553254
申请日：2016-02-22
申请人： Paul Reichert , Winifred W. Prosise , Giovanna Scapin , Xiaoyu Yang , Ramesh Kashi , Corey Strickland , Merck Sharp & Dohme Corp.
发明人： Paul Reichert , Winifred W. Prosise , Giovanna Scapin , Xiaoyu Yang , Ramesh Kashi , Corey Strickland
摘要： Crystals of pembrolizumab and structurally similar anti-PD-1 monoclonal antibodies are provided, as well as methods of producing such crystals, and uses of compositions comprising such antibody crystals, e.g. in treatment of cancers. The present invention satisfies these needs and more by providing pembrolizumab crystals and a method producing pembrolizumab crystals. One embodiment of the method of the invention produces crystals suitable for X-ray diffraction, and the inventors herein used such crystals to solve the three-dimensional structure of pembrolizumab to 2.3 A resolution.
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公开(公告)号：US20080199447A1
公开(公告)日：2008-08-21
申请号：US11961237
申请日：2007-12-20
申请人： Wenyan Wang , Hung V. Le , Jian-Jun Liu , Vincent S. Madison , Winifred W. Prosise , Shahriar Shane Taremi , Li Xiao , Jun Zou
发明人： Wenyan Wang , Hung V. Le , Jian-Jun Liu , Vincent S. Madison , Winifred W. Prosise , Shahriar Shane Taremi , Li Xiao , Jun Zou
CPC分类号： C12N9/6489 , A61K38/00 , C07K14/705 , C07K2299/00 , C07K2319/00
摘要： The present invention discloses purified polypeptides that comprise an active ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides of the present invention. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active ADAM33 catalytic domain. In addition, the present invention discloses methods of using the X-ray diffractable crystals of ADAM33 in structure-based drug design to identify compounds that can modulate the enzymatic activity of ADAM33. The present invention also discloses methods of treating respiratory disorders by administering therapeutic amounts of the ADAM33 catalytic domain.
摘要翻译： 本发明公开了包含活性ADAM33催化结构域的纯化多肽。 此外，本发明公开了编码本发明多肽的核酸。 本发明还公开了生长包含活性ADAM33催化结构域的多肽的X射线衍射晶体的方法。 此外，本发明公开了使用ADAM33的X射线衍射晶体在基于结构的药物设计中鉴定可调节ADAM33的酶活性的化合物的方法。 本发明还公开了通过施用治疗量的ADAM33催化结构域来治疗呼吸系统疾病的方法。
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公开(公告)号：US07335758B2
公开(公告)日：2008-02-26
申请号：US11541982
申请日：2006-10-02
申请人： Wenyan Wang , Hung V. Le , Jian-Jun Liu , Vincent S. Madison , Winifred W. Prosise , Shahriar Shane Taremi , Li Xiao , Jun Zou
发明人： Wenyan Wang , Hung V. Le , Jian-Jun Liu , Vincent S. Madison , Winifred W. Prosise , Shahriar Shane Taremi , Li Xiao , Jun Zou
CPC分类号： C12N9/6489 , A61K38/00 , C07K14/705 , C07K2299/00 , C07K2319/00
摘要： The present invention discloses purified polypeptides that comprise an active ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides of the present invention. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active ADAM33 catalytic domain. In addition, the present invention discloses methods of using the X-ray diffractable crystals of ADAM33 in structure-based drug design to identify compounds that can modulate the enzymatic activity of ADAM33. The present invention also discloses methods of treating respiratory disorders by administering therapeutic amounts of the ADAM33 catalytic domain.
摘要翻译： 本发明公开了包含活性ADAM33催化结构域的纯化多肽。 此外，本发明公开了编码本发明多肽的核酸。 本发明还公开了生长包含活性ADAM33催化结构域的多肽的X射线衍射晶体的方法。 此外，本发明公开了使用ADAM33的X射线衍射晶体在基于结构的药物设计中鉴定可调节ADAM33的酶活性的化合物的方法。 本发明还公开了通过施用治疗量的ADAM33催化结构域来治疗呼吸系统疾病的方法。
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公开(公告)号：US20180237524A1
公开(公告)日：2018-08-23
申请号：US15553254
申请日：2016-02-22
申请人： Paul REICHERT , Winifred W. PROSISE , Giovanna SCAPIN , Xiaoyu YANG , Ramesh KASHI , Corey STRICKLAND , Merck Sharp & Dohme Corp.
发明人： Paul Reichert , Winifred W. Prosise , Giovanna Scapin , Xiaoyu Yang , Ramesh Kashi , Corey Strickland
摘要： Crystals of pembrolizumab and structurally similar anti-PD-1 monoclonal antibodies are provided, as well as methods of producing such crystals, and uses of compositions comprising such antibody crystals, e.g. in treatment of cancers. The present invention satisfies these needs and more by providing pembrolizumab crystals and a method producing pembrolizumab crystals. One embodiment of the method of the invention produces crystals suitable for X-ray diffraction, and the inventors herein used such crystals to solve the three-dimensional structure of pembrolizumab to 2.3 A resolution.
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公开(公告)号：US07208311B2
公开(公告)日：2007-04-24
申请号：US10741204
申请日：2003-12-19
申请人： Wenyan Wang , Hung V. Le , Jian-Jun Liu , Vincent S. Madison , Winifred W. Prosise , Shahriar Shane Taremi , Li Xiao , Jun Zou
发明人： Wenyan Wang , Hung V. Le , Jian-Jun Liu , Vincent S. Madison , Winifred W. Prosise , Shahriar Shane Taremi , Li Xiao , Jun Zou
CPC分类号： C12N9/6489 , A61K38/00 , C07K14/705 , C07K2299/00 , C07K2319/00
摘要： The present invention discloses purified polypeptides that comprise an active ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides of the present invention. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active ADAM33 catalytic domain. In addition, the present invention discloses methods of using the X-ray diffractable crystals of ADAM33 in structure-based drug design to identify compounds that can modulate the enzymatic activity of ADAM33. The present invention also discloses methods of treating respiratory disorders by administering therapeutic amounts of the ADAM33 catalytic domain.
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7.发明授权Compositions of hepatitis C virus NS3/NS4A complex and methods for crystallizing same 失效丙型肝炎病毒NS3 / NS4A复合物的组合物及其结晶方法公开(公告)号：US06524589B1
公开(公告)日：2003-02-25
申请号：US09543376
申请日：2000-04-05
IPC分类号： A61K3929
CPC分类号： C07K14/005 , C07K2299/00 , C12N2770/24222
摘要： The invention relates to the purification and crystallization of hepatitis C virus (HCV) NS3/NS4A polypeptide complex. Also, crystallization conditions for NS3/NS4A are provided. Further, the atomic coordinates for the NS3/NS4A protein are disclosed. Examples of its use for the determination of the three-dimensional atomic structures of HCV NS3/NS4A with substrate(s) or substrate analog(s) or inhibitor complexes are also provided.
摘要翻译： 本发明涉及丙型肝炎病毒（HCV）NS3 / NS4A多肽复合物的纯化和结晶。 另外，提供NS3 / NS4A的结晶条件。 此外，公开了NS3 / NS4A蛋白的原子坐标。 还提供了其用于测定具有底物或底物类似物或抑制剂复合物的HCV NS3 / NS4A的三维原子结构的用途。
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公开(公告)号：US5981167A
公开(公告)日：1999-11-09
申请号：US21480
申请日：1998-02-10
IPC分类号： G01N33/53 , C12Q1/37 , G01N33/543 , G01N33/566 , C12Q1/00
CPC分类号： G01N33/54373 , C12Q1/37 , G01N2333/045 , G01N2333/18
摘要： A method for determining if an enzyme can cleave a substrate or if a substance is an inhibitor of the enzyme using surface plamon resonance.
摘要翻译： 用于确定酶是否可以切割底物的方法，或者如果物质是使用表面plamon共振的酶的抑制剂的方法。
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