发明授权
- 专利标题： Catalytic domain of ADAM33 and methods of use thereof
- 专利标题（中）： ADAM33的催化结构域及其使用方法
-
申请号： US11541982申请日： 2006-10-02
-
公开(公告)号： US07335758B2公开(公告)日： 2008-02-26
- 发明人: Wenyan Wang , Hung V. Le , Jian-Jun Liu , Vincent S. Madison , Winifred W. Prosise , Shahriar Shane Taremi , Li Xiao , Jun Zou
- 申请人： Wenyan Wang , Hung V. Le , Jian-Jun Liu , Vincent S. Madison , Winifred W. Prosise , Shahriar Shane Taremi , Li Xiao , Jun Zou
- 申请人地址： US NJ Kenilworth
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： US NJ Kenilworth
- 主分类号： C12N15/12
- IPC分类号： C12N15/12 ; C12N15/17 ; C12N15/79 ; C12N9/64
摘要：
The present invention discloses purified polypeptides that comprise an active ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides of the present invention. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active ADAM33 catalytic domain. In addition, the present invention discloses methods of using the X-ray diffractable crystals of ADAM33 in structure-based drug design to identify compounds that can modulate the enzymatic activity of ADAM33. The present invention also discloses methods of treating respiratory disorders by administering therapeutic amounts of the ADAM33 catalytic domain.
公开/授权文献
- US20070031401A1 Catalytic domain of ADAM33 and methods of use thereof 公开/授权日：2007-02-08
信息查询
IPC分类:
