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1.发明公开公开(公告)号：US20240299076A1
公开(公告)日：2024-09-12
申请号：US18608958
申请日：2024-03-19
CPC分类号： A61B18/1233 , A61B2017/00159 , A61B2017/00172 , A61B2017/0019 , A61B2018/00577 , A61B2018/00613 , A61B2018/00732 , A61B2018/00767 , A61B2018/1253 , A61B2018/126 , A61B2018/1467 , A61B18/1477 , A61B2090/0409 , A61N1/327
摘要： Methods and systems for distributing electrical energy to tissue which minimize Joule heating, thermal effects, and/or thermal damage, without sacrificing efficacy of treatment, are described. The methods and systems are particularly suitable to electrical energy-based therapies employing multiple electrodes, such as arrays of electrodes.
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公开(公告)号：US20240287329A1
公开(公告)日：2024-08-29
申请号：US18573837
申请日：2022-06-23
申请人： VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. , VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERITY , BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
IPC分类号： C09D11/023 , B29C64/118 , B29C64/209 , B29K21/00 , B29K75/00 , B29K83/00 , B29K105/16 , B29K505/00 , B33Y10/00 , B33Y30/00 , B33Y70/10 , C09D11/102 , C09D11/322
CPC分类号： C09D11/023 , B29C64/118 , B29C64/209 , B33Y10/00 , B33Y30/00 , B33Y70/10 , C09D11/102 , C09D11/322 , B29K2021/003 , B29K2075/00 , B29K2083/00 , B29K2105/16 , B29K2505/00 , B29K2869/00
摘要： In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to methods of additive manufacture of emulsion compositions. In various aspects, the present disclosure relates to composite materials incorporating microstructures formed by inclusion compositions, and methods of their manufacture. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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公开(公告)号：US12065227B2
公开(公告)日：2024-08-20
申请号：US17531007
申请日：2021-11-19
CPC分类号： B63H1/26 , B63B39/00 , B63H21/21 , B63H2021/216
摘要： Various examples of a high-speed omnidirectional fully-actuated underwater propulsion mechanism are described. In one example, a propulsion system includes two decoupled counter-rotating rotors centered on a main axis, with each rotor comprising a plurality of pivotable blades projecting radially from the main axis, a servo-swashplate actuation mechanism comprising a plurality of servos and a linkage assembly connected from the servos to the pivotable blades, a blade-axis re-enforcing flap adapter comprising a plurality of stationary flaps, with the blade-axis re-enforcing flap adapter being positioned in a region between the two decoupled counter-rotating rotors centered on the main axis, and a controller. The controller can be configured to calculate control parameters, compensate a first control parameter among the control parameters to reduce cross-coupling of an unwanted force generated by drag forces on the two decoupled counter-rotating rotors, and generate a control signal for each of the servos based on the control parameters.
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公开(公告)号：US20240254202A1
公开(公告)日：2024-08-01
申请号：US18269156
申请日：2021-12-21
申请人： CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET) , INSTITUTO NACIONAL DE TECNOLOGÍA AGROPECUARIA , VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
发明人： Gladys Viviana PARREÑO , Lorena Itati IBAÑEZ , Marina BOK , Florencia PAVAN , Juan Pablo MALITO , Andrés WIGDOROVITZ , Gisela MARCOPPIDO , Diego FRANCO , Elsa BAUMEISTER , Juan Manuel SCHAMMAS , Lijuan YUAN , Jonathan AUGUSTE
CPC分类号： C07K16/1003 , A61P31/12 , A61K2039/507 , C07K2317/22 , C07K2317/34 , C07K2317/569 , C07K2317/76
摘要： This disclosure is related to llama-derived nanobodies of which the corresponding sequences are provided, corresponding to the variable domain (VHH) of llama heavy chain antibodies recognizing epitopes of the Spike protein of SARS-COV-2, some of them, directed to the receptor binding domain, RBD. The nanobodies disclosed herein have important scientific significance and application prospects, they can be labeled or fused with fluorochromes and enzymes to be used as reagents for immunodetection of the virus. Most importantly, the disclosed nanobodies can be used in the development of a bio-drug for the prevention and clinical treatment of infection and diseases caused by SARS-COV-2.
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公开(公告)号：US20240252553A1
公开(公告)日：2024-08-01
申请号：US18578856
申请日：2022-07-12
发明人： Bahareh BEHKAM , Eric LEAMAN
摘要： Cancer is a significant cause of mortality and morbidity worldwide. One of the principal impediments to the broad success of conventional chemotherapy is poor delivery to and transport within the tumor microenvironment (TME), caused by irregular and leaky vasculature, the lack of functional lymphatics, and underscored by the overproduction of extracellular matrix (ECM) proteins such as collagen. Described herein are engineered Salmonella Typhimurium (S. Typhimurium) bacteria and uses thereof. In some embodiments, the engineered S. Typhimurium bacteria comprises an exogenous collagenase. Also described in exemplary embodiments herein methods of using the engineered S. Typhimurium bacteria, such as part of a,cancer therapy.
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6.发明公开公开(公告)号：US20240240036A1
公开(公告)日：2024-07-18
申请号：US18559525
申请日：2022-05-07
发明人： Ranga PITCHUMANI , Ryan STODDARD
CPC分类号： C09D5/1681 , C23F1/18
摘要： Solid-infused surfaces and articles having solid-infused surfaces are provided. The solid-infused surface includes (a) a substrate with a roughened surface having multi-scale surface roughness and a plurality of substrate asperities, and (b) a low surface-energy polymer coating a portion of the roughened surface forming the solid-infused surface having a fraction of the substrate asperities exposed on the solid-infused surface. The surfaces can be useful, in particular, for promoting condensation heat transfer performance. The articles and surfaces can include electronic components, optical components, or even pipes and other conduits for transporting certain fluids. Methods of making and methods of using the solid-infused surfaces are also provided.
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公开(公告)号：US20240238237A1
公开(公告)日：2024-07-18
申请号：US18289409
申请日：2022-05-04
发明人： Deborah J. Good
IPC分类号： A61K31/201 , A61P1/14 , A61P3/04 , A61P5/24
CPC分类号： A61K31/201 , A61P1/14 , A61P3/04 , A61P5/24
摘要： Described in certain example embodiments herein are methods of and compositions for treating a Snordl l6 deficiency disease or symptom thereof with conjugated linoleic acid (CLA) or a formulation thereof. In some embodiments, the Snordl l6 deficiency disease is Prader-Willi Syndrome. Described in certain example embodiments herein are methods of and compositions for treating Nhlh2 associated hypogonadism with CLA or a formulation thereof.
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公开(公告)号：US20240207041A1
公开(公告)日：2024-06-27
申请号：US18555383
申请日：2022-05-04
发明人： Demitria POULOS , Logan N. DICKINSON , Skye CARLSON , Zachary KOZAR , Jennifer S. WAYNE , Vincent WANG , John R. CLEMENTS
IPC分类号： A61F2/08
CPC分类号： A61F2/0811 , A61F2002/0835 , A61F2002/0852 , A61F2002/0882 , A61F2220/0033 , A61F2220/0075
摘要： Various aspects of an implant for plantar plate repair and a surgical method of plantar plate repair using the implant are described. In one example, the implant includes a female component and a male component. The female component includes an open barrel having an outer surface and an inner surface, a flange cap at one end of the open barrel, and a recessed tiedown bar that extends between openings through the flange cap. The openings through the flange cap extending into the open barrel of the female component. The male impant includes an open barrel portion, a pair of fingers extending from one end of the open barrel portion, and a flange cap at another end of the open barrel portion. The male implant also includes an opening through the flange cap, extending into the open barrel portion of the male implant.
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公开(公告)号：US20240204652A1
公开(公告)日：2024-06-20
申请号：US18068144
申请日：2022-12-19
CPC分类号： H02M1/14 , H02M3/1584
摘要： Aspects of a transient control scheme for a multiphase power converter are described. In one example, a power converter system includes a multiphase power converter that includes a plurality of converter phases, with each converter phase comprising a switching transistor and an inductor coupled between an input power source and a load. The power converter system also includes a controller configured to distribute an on-time signal to each converter phase during operation of the multiphase power converter. The controller includes circuitry configured to enable an on-time signal phase overlap between non-subsequent phases of the multiphase power converter when a load current increase is detected during a transient state of the multiphase power converter. The on-time signal phase overlap refers to a simultaneous on-state of two or more switching transistors of the non-subsequent phases during a duration of time within the transient state.
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公开(公告)号：US12015215B2
公开(公告)日：2024-06-18
申请号：US17607513
申请日：2020-07-08
摘要： Coaxial collinear antenna examples are described. An example coaxial collinear antenna includes a first segment and a second segment of a coaxial cable. The second segment includes a second inner conductor and a second outer conductor. The first inner conductor of the first segment is coupled to the second outer conductor of the second segment. The first outer conductor of the first segment is coupled to the second inner conductor of the second segment. Further, a first wire mesh is attached to the first outer conductor of the first segment, and a second wire mesh is attached to the second outer conductor of the second segment. Additionally, the coaxial collinear antenna includes an end-fed port that is situated at a distal end of the coaxial collinear antenna.
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