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公开(公告)号：US20230011836A1
公开(公告)日：2023-01-12
申请号：US17811275
申请日：2022-07-07
发明人： Omar AZZARONI , Juan Martín GIUSSI , Agustín IBORRA , Isabel VEGA
IPC分类号： C09K8/584 , C08F293/00 , C09K8/588
摘要： A polymeric surfactant for use in chemical enhanced oil recovery, including a terpolymer of a first non-ionic monomer, a second non-ionic monomer, and an ionic monomer, the first non-ionic monomer being a hydrophilic monomer and the second non-ionic monomer being a hydrophobic monomer, the ionic monomer being in a lower proportion than the first and second non-ionic monomers. A method of preparation of polymeric surfactants.
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公开(公告)号：US20220133731A1
公开(公告)日：2022-05-05
申请号：US17433174
申请日：2020-02-20
申请人： CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET) , UNIVERSIDAD NACIONAL DE QUILMES , UNIVERSIDAD DE BUENOS AIRES
发明人： Ernesto J. PODESTÁ , Paula M. MALOBERTI , Ulises D. ORLANDO , Ana F. CASTILLO , Angela R. SOLANO , Pablo LORENZANO MENNA , Daniel E. GOMEZ , Sergio H. SZAJNMAN , Jessica G. PRADA , Juan B. RODRIGUEZ
IPC分类号： A61K31/53 , C07D487/04 , A61K31/704 , A61K31/337 , A61K33/243 , A61P35/00 , A61K31/138
摘要： A new compound of formula A for the treatment of aggressive and/or resistant tumors expressing acyl-CoA synthetase 4 (ACSL4) and/or depending on steroids action. More particularly, the compound of the present invention inhibits tumor growth in ACSL4-expressing breast and prostate cancers, inhibits steroid synthesis and sensitizes cells towards chemotherapeutic and hormone therapy agents. Pharmaceutical compositions comprising the ACSL4-inhibitory compound of the invention, pharmaceutical combinations thereof with other anticancer agents and use in therapy.
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公开(公告)号：US11253847B2
公开(公告)日：2022-02-22
申请号：US16474706
申请日：2017-12-28
申请人： CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) , CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET)
发明人： María Consuelo Álvarez Galván , Martín Dapena Ospina , José Antonio Alonso Alonso , Loreto Troncoso Aguilera , Vanesa Cascos Jiménez , José Miguel Campos Martín , José Luis García Fierro , Horacio Falcón Richeni
摘要： The invention relates to a method for producing catalysts by the method of combustion in solution, to the catalysts produced by said method, and to the particular use thereof in the reverse water-gas shift reaction and in the partial oxidation of the methane into synthesis gas. Therefore, it is understood that the present invention pertains to the area of the green industry aimed at the reduction of CO2 on the planet.
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公开(公告)号：US20210259995A1
公开(公告)日：2021-08-26
申请号：US17313639
申请日：2021-05-06
发明人： Ernesto Jorge PODESTÁ , Ana Fernanda CASTILLO , Ulises Daniel ORLANDO , Paula Mariana MALOBERTI , Angela Rosaria SOLANO
IPC分类号： A61K31/15 , A61P35/00 , A61K31/337 , A61K31/4439 , A61K31/704 , A61K45/06
摘要： Compositions and methods for inhibiting tumor growth, particularly breast cancer, in a combined pharmacological treatment. A pharmaceutical combination for inhibiting growth of a tumor overexpressing ACSL4, comprising a first and a second dosage forms. The first dosage form has an ACSL4 inhibitor and the second dosage form has a chemotherapeutic agent.
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公开(公告)号：US20210123874A1
公开(公告)日：2021-04-29
申请号：US17081561
申请日：2020-10-27
申请人： YPF TECNOLOGÍA S.A. , CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET) , UNIVERSIDAD NACIONAL DE CÓRDOBA
发明人： Rodolfo Hector ACOSTA , Emilia Victoria SILLETTA , Gustavo Alberto MONTI , Yamila GARRO LINCK , Paula Cecilia BEDINI , Gabriela Soledad VILA , Diana María MASIERO , Esteban Alejo DOMENÉ , Manuel Isaac VELASCO
摘要： A method and device for detection of solid organic matter and fluids in a shale rock by means of low field Nuclear Magnetic Resonance (NMR) in a single measurement, by submitting a rock sample to a 2D NMR assay comprising applying a 2D pulse sequence with a saturation-recovery, or inversion-recovery, in an indirect dimension and an FID-CPMG in a direct dimension. The method can be used as an analytical technique for rock samples from unconventional hydrocarbon reservoirs.
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公开(公告)号：US20210093716A1
公开(公告)日：2021-04-01
申请号：US16968528
申请日：2019-02-08
申请人： Juliana CASSATARO , CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET) , UNIVERSIDAD NACIONAL DE GENERAL SAN MARTÍN
IPC分类号： A61K39/395 , C12N15/79
摘要： The present invention relates to modified bacterial polypeptides having immunomodulatory and immunostimulatory activity. Most specifically, the present invention relates to modified bacterial polypeptides having an amino acid sequence selected from SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4 and SEQ ID NO. 5. The modified polypeptides are the adjuvant components of a pharmaceutical composition for eliciting an immune response against an specific antigen present in the pharmaceutical composition. In a preferred embodiment, the invention provides a pharmaceutical composition for a vaccine which comprises an adjuvant component which is any one of the modified polypeptides, one or more antigens, together with a pharmaceutically acceptable excipient.
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公开(公告)号：US10608246B2
公开(公告)日：2020-03-31
申请号：US15827276
申请日：2017-11-30
申请人： YPF TECNOLOGÍA S.A. , CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET) , UNIVERSIDAD NACIONAL DE CÓRDOBA
IPC分类号： H01M4/36 , H01M4/48 , H01M10/0525 , H01M4/587 , H01M4/131 , H01M4/62 , H01M4/1391 , H01M4/02
摘要： The present invention is directed to an anode for a lithium-ion battery and a method of manufacturing the same. The anode is manufactured from a material composed of Si and C known as SBA-15/C having a porous structure of mesopores interconnected by micropores, wherein carbon nanofibers occupy the pore space of the porous structure. The anode has improved conductivity properties and allows to mitigate the drawbacks linked to the volumetric expansion of the anode during the operation of a lithium-ion battery.
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公开(公告)号：US10456465B2
公开(公告)日：2019-10-29
申请号：US14598405
申请日：2015-01-16
申请人： Dana-Farber Cancer Institute, Inc. , The Brigham and Women's Hospital, Inc. , Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) , Fundacion Sales
发明人： Margaret A. Shipp , Jing Ouyang , Kunihiko Takeyama , Jeffery L. Kutok , Scott J. Rodig , Gabriel Rabinovich , Diego Omar Croci Russo , Mariana Salatino
摘要： The present invention is based, in part, on the discovery that galectin-1 (Gal1) plays a role in viral-associated PTLD, e.g., EBV-associated PTLD and hypoxia associated angiogenesis disorders. Accordingly, the invention relates to compositions, kits, and method for diagnosing, prognosing, monitoring, treating and modulating viral-associated PTLD, e.g., EBV-associated PTLD and hypoxia associated angiogenesis disorders.
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公开(公告)号：US20180206756A1
公开(公告)日：2018-07-26
申请号：US15746167
申请日：2016-07-21
发明人： Jorge CASTIÑEIRA MOREIRA , Pablo Daniel AGÜERO , Juan Carlos BONADERO , Alejandro José URIZ , Lucas Andrés RABIOGLIO , María Celeste CEBEDIO
CPC分类号： A61B5/0507 , A61B5/0022 , A61B5/14532 , A61B5/6826 , A61B5/742
摘要： A system for noninvasive measurement of glucose in blood. The system is based in a sensor of the invention. The user must lay its finger on said sensor, which is excited by means of a radiofrequency sweep generation. The responses of magnitude and phase as a function of the frequency of the reflected wave are measured by an amplitude and phase detector. Said magnitudes are acquired by two analog-to-digital converters of a microcontroller, which in turn has the ability of transmitting them to other devices such as for example a computer or a smart phone.
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10.发明公开公开(公告)号：US20240197892A1
公开(公告)日：2024-06-20
申请号：US18590749
申请日：2024-02-28
申请人： Skybio LLC , Consejo Nacional de Investigaciones Científicas y Técnicas (Conicet) , Universidad Nacional de Tucumán , Universidad de Buenos Aires , Sistema Provincial De Salud De Tucumán
发明人： Oscar José Varela , Rosana Nieves Chehín , Cesar Luis Ávila , Sergio Benjamin Socías , Diego Ploper , Esteban Vera Pingitore , Analía Silvina Chaves , Martin Luong , Verónica Elena Manzano , Rodrigo Hernán Tomas Grau , Maria Florencia González Lizárraga , Adriana Andrea Kolender , Agustín Osvaldo Pernicone
IPC分类号： A61K47/55
CPC分类号： A61K47/552
摘要： The present disclosure provides a compound comprising a modified tetracycline derivative, covalently coupled through a linker defined by the generic formula XZX to a low-hydrophobicity bioactive molecule useful for treating neurodegenerative diseases, particularly a compound wherein the modified tetracycline derivative is a chemically modified doxycycline derivative and the low-hydrophobicity bioactive molecule useful for treating neurodegenerative diseases is dopamine. The disclosure also provides a process for preparing such compound, as well as methods for treating a neurodegenerative disease comprising administering said compound.
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