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    Process for producing antibodies to hepatitis virus and cell lines therefor
    1.
    发明授权
    Process for producing antibodies to hepatitis virus and cell lines therefor 失效
    用于产生针对肝炎病毒及其细胞系的抗体的方法

    公开(公告)号：US4491632A

    公开(公告)日：1985-01-01

    申请号：US516672

    申请日：1983-07-26

    申请人： Jack R. Wands ,  Vincent R. Zurawski, Jr.

    发明人： Jack R. Wands ,  Vincent R. Zurawski, Jr.

    IPC分类号： A61K39/42 ,  G01N33/577 ,  C12N5/00 ,  C12N15/00

    CPC分类号： A61K39/42 ,  G01N33/577

    摘要： Cell lines for producing monoclonal antibodies to hepatitis virus are established by immunizing animal lymphocytes with hepatitis antigen to form antibody producing cells which then are fused with myeloma cells. The resultant somatic cell hybrids can be cloned. These clones produce monoclonal antibodies to individual antigenic determinates unique to hepatitis virus.

    摘要翻译： 用于产生肝炎病毒单克隆抗体的细胞系通过用肝炎抗原免疫动物淋巴细胞来形成抗体产生细胞，然后与骨髓瘤细胞融合。 可以克隆所得体细胞杂交体。 这些克隆产生针对肝炎病毒特有的单个抗原决定因子的单克隆抗体。

    Process for rosetting human B lymphocytes with Rhesus monkey erythrocyte
    2.
    发明授权
    Process for rosetting human B lymphocytes with Rhesus monkey erythrocyte 失效
    用恒河猴红细胞培养人B淋巴细胞的方法

    公开(公告)号：US4192917A

    公开(公告)日：1980-03-11

    申请号：US27307

    申请日：1979-04-05

    申请人： Vincent R. Zurawski, Jr.

    发明人： Vincent R. Zurawski, Jr.

    IPC分类号： C07K16/42 ,  C12N5/0781 ,  C12N7/04 ,  A61K39/00

    CPC分类号： C07K16/4208 ,  C12N5/0635 ,  C12N2501/59

    摘要： Human peripheral blood lymphocytes are stimulated with either a polyclonal activator or an antigen which gives rise to immunologically activated B lymphocytes. These activated B lymphocytes are separated from non-activated B lymphocytes by relying on the fact that activated B lymphocytes possess a surface marker; the ability to rosette Rhesus monkey lymphocytes (RhMRBC), not found on their non-activated counterparts. Separation is achieved by rosetting with RhMRBC and subsequent density centrifugation of cells.

    摘要翻译： 人外周血淋巴细胞用多克隆激活剂或产生免疫激活的B淋巴细胞的抗原刺激。 这些活化的B淋巴细胞通过依赖于活化的B淋巴细胞具有表面标记物的事实与非活化的B淋巴细胞分离; 莲藕猴淋巴细胞（RhMRBC）的能力，未发现在其未激活的对应物上。 通过用RhMRBC和随后的细胞密度离心的玫瑰化来实现分离。

    Hepatitis C virus vaccine
    6.
    发明授权
    Hepatitis C virus vaccine 失效
    丙型肝炎病毒疫苗

    公开(公告)号：US06235888B1

    公开(公告)日：2001-05-22

    申请号：US08869380

    申请日：1997-06-05

    申请人： Catherine J. Pachuk ,  Jack Wands ,  Takaji Wakita ,  Vincent R. Zurawski, Jr. ,  Leslie R. Coney

    发明人： Catherine J. Pachuk ,  Jack Wands ,  Takaji Wakita ,  Vincent R. Zurawski, Jr. ,  Leslie R. Coney

    IPC分类号： C07H2104

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00 ,  C12N2730/10122 ,  C12N2770/24222 ,  C12N2770/24234

    摘要： Nucleic acid molecule that comprise an incomplete hepatitis C viral genome including specifically disclosed DNA sequences are disclosed. Pharmaceutical compositions that contain nucleic acid molecules comprising an incomplete hepatitis C viral genome including a nucleotide sequence encoding a complete hepatitis C core protein operably linked to regulatory elements functional in human cells are disclosed. Methods of immunizing individuals susceptible to or infected by hepatitis C virus comprising the step of administering such pharmaceutical compositions are disclosed.

    摘要翻译： 公开了包含特异性公开的DNA序列的包含不完全丙型肝炎病毒基因组的核酸分子。 公开了含有包含不完全丙型肝炎病毒基因组的核酸分子的药物组合物，其包括编码与人细胞中有功能的调控元件可操作地连接的完整丙型肝炎核心蛋白的核苷酸序列。 公开了对丙型肝炎病毒感染或感染的个体进行免疫的方法，包括施用该药物组合物的步骤。