Methods for promoting HSC self-renewal
    1.
    发明授权
    Methods for promoting HSC self-renewal 有权
    促进HSC自我更新的方法

    公开(公告)号:US09028811B2

    公开(公告)日:2015-05-12

    申请号:US13431563

    申请日:2012-03-27

    摘要: The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.

    摘要翻译: 本发明提供了通过使用HCS调节剂调节造血干细胞群体的组合物和方法,所述HCS调节剂是根据特定适应症所希望的增加HSC数量或降低HSC数量的药剂。 例如,发现增加HSC数量的HSC调节剂包括前列腺素E2(PGE2)和刺激PGE2途径的试剂。 相反,防止PGE2合成的HSC调节剂降低HSC数。 HCS调节剂可以在体外,体内或体外使用。

    METHODS FOR PROMOTING HSC ENGRAFTMENT
    3.
    发明申请
    METHODS FOR PROMOTING HSC ENGRAFTMENT 有权
    促进HSC ENGRAFTMENT的方法

    公开(公告)号:US20120189593A1

    公开(公告)日:2012-07-26

    申请号:US13431534

    申请日:2012-03-27

    摘要: The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.

    摘要翻译: 本发明提供了通过使用HCS调节剂调节造血干细胞群体的组合物和方法,所述HCS调节剂是根据特定适应症所希望的增加HSC数量或降低HSC数量的药剂。 例如,发现增加HSC数量的HSC调节剂包括前列腺素E2(PGE2)和刺激PGE2途径的试剂。 相反,防止PGE2合成的HSC调节剂降低HSC数。 HCS调节剂可以在体外,体内或体外使用。

    Method to modulate hematopoietic stem cell growth
    4.
    发明授权
    Method to modulate hematopoietic stem cell growth 有权
    调节造血干细胞生长的方法

    公开(公告)号:US08168428B2

    公开(公告)日:2012-05-01

    申请号:US12294344

    申请日:2007-04-26

    IPC分类号: C12N5/00 C12N5/02

    摘要: The present invention provides for compositions and methods for modulating hematopoietic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.

    摘要翻译: 本发明提供了通过使用HCS调节剂调节造血干细胞群体的组合物和方法,所述HCS调节剂是根据特定适应症所希望的增加HSC数量或降低HSC号的试剂。 例如,发现增加HSC数量的HSC调节剂包括前列腺素E2(PGE2)和刺激PGE2途径的试剂。 相反,防止PGE2合成的HSC调节剂降低HSC数。 HCS调节剂可以在体外,体内或体外使用。

    Methods for promoting hematopoietic reconstitution
    5.
    发明授权
    Methods for promoting hematopoietic reconstitution 有权
    促进造血重建的方法

    公开(公告)号:US08563310B2

    公开(公告)日:2013-10-22

    申请号:US13431499

    申请日:2012-03-27

    IPC分类号: C12N5/00 C12N5/02

    摘要: The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.

    摘要翻译: 本发明提供了通过使用HCS调节剂调节造血干细胞群体的组合物和方法,所述HCS调节剂是根据特定适应症所希望的增加HSC数量或降低HSC数量的药剂。 例如,发现增加HSC数量的HSC调节剂包括前列腺素E2(PGE2)和刺激PGE2途径的试剂。 相反,防止PGE2合成的HSC调节剂降低HSC数。 HCS调节剂可以在体外,体内或体外使用。

    Methods for promoting HSC engraftment
    7.
    发明授权
    Methods for promoting HSC engraftment 有权
    促进HSC植入的方法

    公开(公告)号:US08551782B2

    公开(公告)日:2013-10-08

    申请号:US13431534

    申请日:2012-03-27

    IPC分类号: C12N5/00 C12N5/02

    摘要: The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.

    摘要翻译: 本发明提供了通过使用HCS调节剂调节造血干细胞群体的组合物和方法,所述HCS调节剂是根据特定适应症所希望的增加HSC数量或降低HSC数量的药剂。 例如,发现增加HSC数量的HSC调节剂包括前列腺素E2(PGE2)和刺激PGE2途径的试剂。 相反,防止PGE2合成的HSC调节剂降低HSC数。 HCS调节剂可以在体外,体内或体外使用。

    METHODS FOR PROMOTING HSC SELF-RENEWAL
    8.
    发明申请
    METHODS FOR PROMOTING HSC SELF-RENEWAL 有权
    促进HSC自我更新的方法

    公开(公告)号:US20120189594A1

    公开(公告)日:2012-07-26

    申请号:US13431563

    申请日:2012-03-27

    摘要: The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.

    摘要翻译: 本发明提供了通过使用HCS调节剂调节造血干细胞群体的组合物和方法,所述HCS调节剂是根据特定适应症所希望的增加HSC数量或降低HSC数量的药剂。 例如,发现增加HSC数量的HSC调节剂包括前列腺素E2(PGE2)和刺激PGE2途径的试剂。 相反,防止PGE2合成的HSC调节剂降低HSC数。 HCS调节剂可以在体外,体内或体外使用。

    METHODS FOR PROMOTING HEMATOPOIETIC RECONSTITUTION
    9.
    发明申请
    METHODS FOR PROMOTING HEMATOPOIETIC RECONSTITUTION 有权
    促进血细胞重建的方法

    公开(公告)号:US20120189592A1

    公开(公告)日:2012-07-26

    申请号:US13431499

    申请日:2012-03-27

    摘要: The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.

    摘要翻译: 本发明提供了通过使用HCS调节剂调节造血干细胞群体的组合物和方法,所述HCS调节剂是根据特定适应症所希望的增加HSC数量或降低HSC数量的药剂。 例如,发现增加HSC数量的HSC调节剂包括前列腺素E2(PGE2)和刺激PGE2途径的试剂。 相反,防止PGE2合成的HSC调节剂降低HSC数。 HCS调节剂可以在体外,体内或体外使用。