发明申请
- 专利标题： METHOD TO MODULATE HEMATOPOIETIC STEM CELL GROWTH
- 专利标题（中）： 调节HEMATOPOIETIC干细胞生长的方法
-
申请号： US12994527申请日： 2009-05-28
-
公开(公告)号： US20110206781A1公开(公告)日： 2011-08-25
- 发明人: Leonard I. Zon , Trista E. North , Wolfram Goessling
- 申请人： Leonard I. Zon , Trista E. North , Wolfram Goessling
- 国际申请： PCT/US09/45442 WO 20090528
- 主分类号： A61K33/00
- IPC分类号： A61K33/00 ; C12N5/0789 ; A61K31/197 ; A61K31/517 ; A61K31/138 ; A61K31/4418 ; A61K31/7048 ; A61K31/198 ; A61K31/295 ; A61K31/165 ; A61K31/4985 ; A61K31/137 ; A61K31/44 ; A61K31/353 ; A61K31/216 ; A61P7/00
摘要：
Described herein are methods, compositions and kits related to manipulating hematopoietic stem cells (HSC) and more particularly to methods, compositions and kits related to increasing the number of hematopoietic stem cells in vitro, ex vivo and/or in vivo. Also described are methods, compositions and kits related to making an expanded population of HSC and methods, compositions and kits related to using the expanded population of HSC. For example, HSC growth may be enhanced by contacting the nascent stem cells or HSC with an agent that stimulates the nitric oxide signaling pathway.
信息查询
