Invention Application
- Patent Title: METHODS FOR PROMOTING HEMATOPOIETIC RECONSTITUTION
- Patent Title (中): 促进血细胞重建的方法
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Application No.: US13431499Application Date: 2012-03-27
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Publication No.: US20120189592A1Publication Date: 2012-07-26
- Inventor: Leonard I. Zon , Trista E. North , Wolfram Goessling
- Applicant: Leonard I. Zon , Trista E. North , Wolfram Goessling
- Applicant Address: US MA Boston US MA Boston
- Assignee: THE GENERAL HOSPITAL CORPORATION,CHILDREN'S MEDICAL CENTER CORPORATION
- Current Assignee: THE GENERAL HOSPITAL CORPORATION,CHILDREN'S MEDICAL CENTER CORPORATION
- Current Assignee Address: US MA Boston US MA Boston
- Main IPC: A61K35/14
- IPC: A61K35/14 ; A61K35/50 ; A61P35/00 ; A61K35/28 ; A61P7/06 ; A61P7/00
Abstract:
The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
Public/Granted literature
- US08563310B2 Methods for promoting hematopoietic reconstitution Public/Granted day:2013-10-22
Information query
IPC分类:
