公开(公告)号：US06290723B1

公开(公告)日：2001-09-18

申请号：US08459721

申请日：1995-06-02

Applicant: Winston A. Andrews ,  Gloria R. Dumlao ,  Terry R. Knapp

Inventor： Winston A. Andrews ,  Gloria R. Dumlao ,  Terry R. Knapp

IPC: A61F212

CPC classification number: A61L27/00 ,  A61F2/08 ,  A61F2/12 ,  A61F2/26 ,  A61L27/50 ,  Y10S623/901 ,  Y10S623/926

Abstract: A filler material for a surgically implantable prosthesis comprised of a synthetic triglyceride having a viscosity substantially greater than that of naturally occurring triglycerides is provided. The triglyceride composition is formed of saturated alkyl chains to reduce or limit the potential for oxidation of the alkyl chains to form peroxide groups which adversely affect the biocompatibility of the filler material and the implant. Preferably, the filler material has a viscosity substantially the equivalent of a normal human breast. The synthetic triglyceride filler material may also have a lower viscosity which is a liquid at room temperature for use in inflatable devices. Prostheses containing filler material having the desired viscosity and antioxidation characteristics are also provided as well as a method for preparing the filler material.

Abstract translation: 提供了一种用于手术可植入的假体的填充材料，其由具有比天然存在的甘油三酯的粘度显着更大的粘度的合成甘油三酯组成。 甘油三酸酯组合物由饱和烷基链形成，以减少或限制烷基链氧化的可能性，形成对填料和植入物的生物相容性产生不利影响的过氧化物基团。 优选地，填充材料具有基本上等于正常人乳房的粘度。 合成甘油三酯填料也可以具有较低的粘度，其在室温下是用于充气装置的液体。 还提供了含有具有所需粘度和抗氧化特性的填充材料的假体以及制备填充材料的方法。

公开(公告)号：US06251137B1

公开(公告)日：2001-06-26

申请号：US08259474

申请日：1994-06-14

Applicant: Winston A. Andrews ,  Gloria R. Dumlao ,  Terry R. Knapp

Inventor： Winston A. Andrews ,  Gloria R. Dumlao ,  Terry R. Knapp

IPC: A61F212

CPC classification number: A61L27/00 ,  A61F2/08 ,  A61F2/12 ,  A61F2/26 ,  A61L27/50

Abstract: A filler material for a surgically implantable prosthesis comprised of a synthetic triglyceride having a viscosity substantially greater than that of naturally occurring triglycerides is provided. The triglyceride composition is formed of saturated alkyl chains to reduce or limit the potential for oxidation of the alkyl chains to form peroxide groups which adversely affect the biocompatibility of the filler material and the implant. Preferably, the filler material has a viscosity substantially the equivalent of a normal human breast. The synthetic triglyceride filler material may also have a lower viscosity which is a liquid at room temperature for use in inflatable devices. Prostheses containing filler material having the desired viscosity and antioxidation characteristics are also provided as well as a method for preparing the filler material.

Abstract translation: 提供了一种用于手术可植入的假体的填充材料，其由具有比天然存在的甘油三酯的粘度显着更大的粘度的合成甘油三酯组成。 甘油三酸酯组合物由饱和烷基链形成，以减少或限制烷基链氧化的可能性，形成对填料和植入物的生物相容性产生不利影响的过氧化物基团。 优选地，填充材料具有基本上等于正常人乳房的粘度。 合成甘油三酯填料也可以具有较低的粘度，其在室温下是用于充气装置的液体。 还提供了含有具有所需粘度和抗氧化特性的填充材料的假体以及制备填充材料的方法。

公开(公告)号：US5833603A

公开(公告)日：1998-11-10

申请号：US614519

申请日：1996-03-13

Applicant: Gregory T. A. Kovacs ,  Terry R. Knapp

Inventor： Gregory T. A. Kovacs ,  Terry R. Knapp

IPC: A61B5/00 ,  G01J3/02 ,  A61B10/00

CPC classification number: A61B1/00029 ,  A61B1/00016 ,  A61B1/0653 ,  A61B5/0031 ,  A61B5/413 ,  G01J3/02 ,  G01J3/0256 ,  G01J3/0291 ,  A61B1/041 ,  A61B1/0684 ,  A61B2560/0214 ,  A61B2560/0219 ,  A61B2562/08

Abstract: A biosensing transponder for implantation in an organism including a human comprises a biosensor for sensing one or more physical properties related to the organism after the device has been implanted, including optical, mechanical, chemical, and electrochemical properties, and a transponder for wirelessly transmitting data corresponding to the sensed parameter value to a remote reader. Disclosed embodiments utilize temperature sensors, strain sensors, pressure sensors, magnetic sensors, acceleration sensors, ionizing radiation sensors, acoustic wave sensors, chemical sensors including direct chemical sensors and dye based chemical sensors, and photosensors including imagers and integrated spectrophotometers. The transponder includes an energy coupler for wirelessly energizing the device with a remote energy source, and a control circuit for controlling and accessing the biosensor and for storing identifying data. The energy coupler can be an inductive circuit for coupling electromagnetic energy, a photoelectric transducer for coupling optical energy, or a piezoelectric transducer for coupling ultrasonic energy. The control circuit can be configured to delay, either randomly or by a fixed period of time, transmission of data indicative of the sensed parameter value to thereby prevent a data collision with an adjacent like device. Methods for using an implantable biosensing transponder include the steps of associating the device with an implant, including temporary implants, prostheses, and living tissue implants, physically attaching the device to a flexible catheter, sensing parameter values in an organism, and transmitting data corresponding to the sensed parameter values to a remote reader.

Abstract translation: 用于植入包括人的生物体的生物传感应答器包括用于感测在器件植入后与生物相关的一种或多种物理性质的生物传感器，包括光学，机械，化学和电化学性质，以及用于无线传输数据的应答器 对应于感测到的远程读取器的参数值。 公开的实施例使用温度传感器，应变传感器，压力传感器，磁传感器，加速度传感器，电离辐射传感器，声波传感器，包括直接化学传感器和基于染料的化学传感器的化学传感器，以及包括成像器和集成分光光度计的光电传感器。 应答器包括能量耦合器，用于利用远程能量源无线地激励装置，以及用于控制和访问生物传感器并存储识别数据的控制电路。 能量耦合器可以是用于耦合电磁能的感应电路，用于耦合光能的光电传感器，或用于耦合超声波能量的压电传感器。 控制电路可以被配置为随机地或者固定的时间段延迟指示所感测的参数值的数据的传输，从而防止与相邻的类似设备的数据冲突。 使用植入式生物传感应答器的方法包括以下步骤：将装置与植入物相关联，包括临时植入物，假体和活组织植入物，将装置物理地连接到柔性导管，感测生物体中的参数值，以及发送对应于 感测到的参数值给远程读取器。

公开(公告)号：US5653758A

公开(公告)日：1997-08-05

申请号：US469479

申请日：1995-06-06

Applicant: John R. Daniels ,  Terry R. Knapp

Inventor： John R. Daniels ,  Terry R. Knapp

IPC: A61N5/00 ,  A61B19/00 ,  A61F2/02 ,  A61L27/18 ,  A61L27/50 ,  A61F2/12 ,  A61F2/54

CPC classification number: A61L27/50 ,  A61B90/00 ,  A61L27/18 ,  A61B2017/00902 ,  A61B2090/0815

Abstract: A temporarily implantable organ displacement implant is comprised of a bladder with a one-way valve for being filled with a fluid for displacement of a healthy organ from a tissue site desired to be irradiated by radiation therapy. This organ displacement implant is substantially radiolucent which thereby facilitates its placement and minimizes its interference with the radiation therapy.

Abstract translation: 临时可植入器官置换植入物包括具有单向阀的囊，用于填充用于将健康器官从期望被辐射治疗照射的组织部位移位的流体。 该器官置换植入物基本上是可透射的，由此有利于其放置并使其与放射治疗的干扰最小化。

公开(公告)号：US3949073A

公开(公告)日：1976-04-06

申请号：US524672

申请日：1974-11-18

Applicant: John R. Daniels ,  Terry R. Knapp

Inventor： John R. Daniels ,  Terry R. Knapp

IPC: A61F2/00 ,  A61K38/00 ,  A61L27/24 ,  C07K14/78 ,  A61K37/00 ,  A01N9/00

CPC classification number: A61L27/24 ,  C07K14/78 ,  A61F2310/00365 ,  A61K38/00 ,  Y10S128/08 ,  Y10S514/801 ,  Y10S623/92

Abstract: A method for augmenting hard or soft connective tissue, such as skin, tendon, cartilage, bone or interstitium, in a living mammal comprising implanting a proteolytic enzyme-solubilized, purified, native, in situ polymerizable collagen solution into the mammal at the augmentation site. The solution polymerizes at the site into a stable, non-reactive fibrous mass of tissue which is rapidly colonized by host cells and vascularized.

Abstract translation: 一种用于在活的哺乳动物中增加硬或软结缔组织如皮肤，腱，软骨，骨或间质的方法，包括在增生部位植入蛋白水解酶溶解，纯化的天然原位聚合的胶原溶液到哺乳动物中 。 该溶液在该部位聚合成稳定的非反应性纤维组织，其被宿主细胞迅速定殖并血管化。

公开(公告)号：US5939609A

公开(公告)日：1999-08-17

申请号：US46220

申请日：1998-03-23

Applicant: Terry R. Knapp ,  Robert B. Smith

Inventor： Terry R. Knapp ,  Robert B. Smith

IPC: G01D21/02 ,  G01N1/00

CPC classification number: G01D21/02

Abstract: The multi-use sensor has a controllable number of measurement cycles. This multi-use sensor consists of a sensor and/or electrodes that are encased in a suitable material to allow reuse of the sensor and sensor life cycle circuitry that functions to regulate the number of operational cycles that the sensor can execute to ensure that the multi-use sensor is not used beyond its effective life. Included in this life cycle circuitry is a dual state mechanism that is connected across two conductors and that has a first state of low impedance. There is sensor state change apparatus that changes the state of the dual state mechanism to a second state of high impedance, such as an open circuit between the two conductors. The sensor state change apparatus determines the state of the dual state mechanism and, if the dual state mechanism is in the first state, it applies a control signal to the dual state mechanism to switch this mechanism into the second state upon activation of the multi-use sensor to perform a measurement. Once the dual state mechanism is in the second state, a processor maintains a count of the number of times that the multi-use is operated to perform a measurement. Once the maintained count reaches a predetermined count, the processor disables the multi-use sensor to prevent it from being used beyond its predetermined useful life.

Abstract translation: 多用途传感器具有可控数量的测量周期。 这种多用途传感器由传感器和/或电极组成，该传感器和/或电极被封装在合适的材料中，以允许重用传感器和传感器寿命周期电路，其功能用于调节传感器可执行的操作周期数，以确保多 - 使用传感器不能超过其有效寿命。 包括在该生命周期电路中的是双态机制，其连接在两个导体上并具有第一低阻抗状态。 存在将双状态机构的状态改变为高阻抗的第二状态的传感器状态改变装置，例如两个导体之间的开路。 传感器状态改变装置确定双重状态机制的状态，并且如果双状态机制处于第一状态，则它将控制信号施加到双状态机构，以在多状态机构激活时将该机构切换到第二状态， 使用传感器进行测量。 一旦双重状态机制处于第二状态，处理器维持多次使用的次数来执行测量。 一旦保持的计数达到预定计数，则处理器禁用多用途传感器以防止其超出其预定使用寿命。

公开(公告)号：US5855609A

公开(公告)日：1999-01-05

申请号：US375811

申请日：1995-01-20

Applicant: Terry R. Knapp

Inventor： Terry R. Knapp

IPC: A61B5/00 ,  A61B5/07 ,  A61B5/117 ,  A61B19/00 ,  A61F2/00 ,  A61F2/02 ,  G08C17/04 ,  A61F2/54

CPC classification number: A61B5/411 ,  A61B5/0031 ,  A61B90/98 ,  A61F2/02 ,  G08C17/04 ,  A61B2562/08 ,  A61B5/076 ,  A61F2250/0002 ,  A61F2250/0098 ,  Y10S623/914

Abstract: A passive electrical transponder may be encoded with a code corresponding to medical information, and the transponder directly transplanted in a patient's underarm area. Medical devices may also carry transponders to identify them for use with the system of the present invention. The code may be accessed with an electromagnetic hand held reader which is brought into proximity of the transponder. The medical information may itself be directly encoded into the transponder, or a code used which is then keyed to a corresponding data entry in a data bank or computerized data base accessible over telecommunication lines. With this invention, medical information may be reliably and confidentially recorded, maintained, and accessed with minimal patient involvement in order to achieve a high degree of reliability and accuracy. Also, medical information relating to patients and medical devices may be centrally collected over an extended time period and analyzed to generate recall notices, provide generalized health information and improve health care for all participants.

Abstract translation: 无源电子应答器可以用对应于医疗​​信息的代码编码，并且应答器直接移植到患者的腋下区域中。 医疗设备还可以携带应答器来识别它们以用于本发明的系统。 可以使用电磁手持式读取器来访问代码，该读取器被带到转发器附近。 医疗信息本身可以直接编码到应答器中，或者所使用的代码，然后键入到通过电信线路可访问的数据库或计算机化数据库中的相应数据条目。 利用本发明，医疗信息可以以最小的患者参与来可靠和保密地记录，维护和访问，以便实现高度的可靠性和准确性。 此外，与患者和医疗器械有关的医疗信息可以在延长的时间段内集中收集，并进行分析以产生召回通知，提供广泛的健康信息并改善所有参与者的保健。

公开(公告)号：US5824081A

公开(公告)日：1998-10-20

申请号：US710180

申请日：1996-09-13

Applicant: Terry R. Knapp ,  Winston A. Andrews ,  Pierre Comte

Inventor： Terry R. Knapp ,  Winston A. Andrews ,  Pierre Comte

IPC: A61F2/12 ,  A61L27/56 ,  A61F2/02

CPC classification number: A61F2/12 ,  A61L27/56

Abstract: The invention relates to a tissue implant having visco-elastic characteristics which simulate the natural tissue that is intended to be augmented or replaced. The implant is comprised of a shell or envelope enclosing a compound foam body and a fluid filler material. Both the foam body and the fluid filler are should be biocompatible and preferably are substantially radiolucent using standard mammographic materials and protocols. The compound foam body is of elastomeric cellular foam materials. Intercellular communication of the fluid filler provides a hydraulic mechanism for imparting shape and tissue-like consistency to the implant. The compound foam body has multiple regions, each region having a different cellular density, for simulating the tactile characteristics of the natural tissue that the implant is intended to augment or replace. The implant may also have a cavity in the compound foam body configured for providing a hydraulic reservoir for the fluid filler. The resiliency of the compound foam body permits realistic elastic deformation, in response to external pressure, and "rebound" following such deformation.

Abstract translation: 本发明涉及具有粘弹性特征的组织植入物，其模拟拟增加或替换的天然组织。 植入物由围绕复合泡沫体和流体填充材料的外壳或信封构成。 泡沫体和流体填充物都应该是生物相容的，并且优选地使用标准乳房X射线成像材料和方案实质上是可透射的。 复合泡沫体是弹性体泡沫材料。 流体填充物的细胞间通信提供了用于赋予植入物形状和组织样稠度的液压机构。 复合泡沫体具有多个区域，每个区域具有不同的细胞密度，用于模拟植入物旨在增加或替代的天然组织的触觉特性。 所述植入物还可以具有在所述复合泡沫体中具有用于为所述流体填充物提供液压储存器的空腔。 复合泡沫体的弹性允许响应于外部压力的现实弹性变形和这种变形之后的“回弹”。

公开(公告)号：US5300120A

公开(公告)日：1994-04-05

申请号：US934785

申请日：1992-08-24

Applicant: Terry R. Knapp ,  Thomas L. Monsees ,  Winston A. Andrews

Inventor： Terry R. Knapp ,  Thomas L. Monsees ,  Winston A. Andrews

IPC: A61F2/00 ,  A01K11/00 ,  A61B5/00 ,  A61B5/07 ,  A61B5/117 ,  A61B17/74 ,  A61B17/80 ,  A61B19/00 ,  A61F2/02 ,  A61F2/12 ,  A61F2/26 ,  A61F2/28 ,  A61F2/30 ,  A61F2/38 ,  A61F2/40 ,  A61F2/42 ,  G08C17/04

CPC classification number: A01K11/006 ,  A61B5/0031 ,  A61B5/117 ,  A61B90/98 ,  A61F2/02 ,  G08C17/04 ,  A61B17/746 ,  A61B17/8085 ,  A61B2562/08 ,  A61B5/076 ,  A61B90/39 ,  A61F2/12 ,  A61F2/26 ,  A61F2/38 ,  A61F2/40 ,  A61F2/4241 ,  A61F2002/2807 ,  A61F2002/3008 ,  A61F2002/3067 ,  A61F2002/30672 ,  A61F2002/30677 ,  A61F2002/3071 ,  A61F2250/0002 ,  A61F2250/0059 ,  A61F2250/0067 ,  A61F2250/0085 ,  A61F2250/0098 ,  A61F2310/00023 ,  Y10S623/912 ,  Y10S623/914

Abstract: A passive transponder may be encoded with a number or code of up to 64 binary bits and then mounted to virtually any prosthesis implanted in a human, such as a breast implant. After implantation, the transponder's code may be conveniently read with a hand held electromagnetic reader which may merely be brought within proximity of the transponder. The encoded transponder may thus be read in a non-invasive procedure and without the use of any sophisticated or potentially harmful medical equipment or technology such as X-ray. The information encoded in the transponder may correspond to patient demographics and implant data to aid in tracking the implant's manufacturer and use for medical as well as legal reasons.

Abstract translation: 无源应答器可以用多达64个二进制位的数字或代码进行编码，然后安装到实际上植入人体的任何假体，例如乳房植入物。 植入后，可以用手持式电磁读取器方便地读取应答器的代码，手持式电磁读取器可能只能被置于应答器的附近。 因此编码的应答器可以非侵入性的程序读取而不使用任何复杂的或潜在有害的医疗设备或技术，如X射线。 在应答器中编码的信息可以对应于患者人口统计学和植入物数据，以帮助跟踪植入物的制造商以及用于医疗以及法律上的原因。

公开(公告)号：US5977431A

公开(公告)日：1999-11-02

申请号：US915907

申请日：1997-08-21

Applicant: Terry R. Knapp ,  John Steuart

Inventor： Terry R. Knapp ,  John Steuart

IPC: A61B5/07 ,  A61B5/117 ,  A61B19/00 ,  A61F2/00 ,  A61F2/02

CPC classification number: A61F2/02 ,  A61B5/117 ,  A61B5/413 ,  A61B90/39 ,  A61B90/98 ,  A61B5/076 ,  A61F2250/0098 ,  Y10S623/912

Abstract: A passive transponder may be encoded with a number or code of up to 64 binary bits and then associated with or mounted to virtually any living tissue implant for implantation in a human. After implantation, the transponder's code may be conveniently read with a hand held electromagnetic reader which may merely be brought within proximity of the transponder. The encoded transponder may thus be read in a non-invasive procedure and without the use of any sophisticated or potentially harmful medical equipment or technology such as X-ray. The information encoded in the transponder may correspond to patient demographics and implant data to aid in tracking the implant's progress and use for medical as well as legal reasons.

Abstract translation: 无源应答器可以用多达64个二进制位的数字或代码进行编码，然后与几乎任何用于植入人体的活体组织植入物相关联或安装在其上。 植入后，可以用手持式电磁读取器方便地读取应答器的代码，手持式电磁读取器可能只能被置于应答器的附近。 因此编码的应答器可以非侵入性的程序读取而不使用任何复杂的或潜在有害的医疗设备或技术，如X射线。 在应答器中编码的信息可以对应于患者人口统计学和植入物数据，以帮助跟踪植入物的进展并且用于医疗以及法律上的原因。