公开(公告)号：US08658815B2

公开(公告)日：2014-02-25

申请号：US13138709

申请日：2010-03-18

申请人： Takahiro Fujiwara ,  Hideki Nara

发明人： Takahiro Fujiwara ,  Hideki Nara

IPC分类号： C07F15/00

CPC分类号： C07F15/0046 ,  C07F17/02

摘要： The present invention provides a method for inexpensively producing di-μ-chloro-bis[chloro(η6-1-isopropyl-4-methylbenzene)ruthenium (II)] complex used as a catalyst raw material for a hydrogenation or metathesis polymerization reaction at a high yield. In the present invention, the above-described problem can be solved by reacting ruthenium chloride or a hydrate thereof with γ-terpinene in a solvent. In particular, by using an alcohol having a boiling point of 100° C. or higher as a solvent, the yield of the above-described complex can be increased.

摘要翻译： 本发明提供了一种低成本生产用作氢化或易位聚合反应的催化剂原料的二氯氯 - 双[氯（eta6-1-异丙基-4-甲苯）钌（II）]络合物的方法， 高产。 在本发明中，上述问题可以通过使氯化钌或其水合物与γ-萜品烯在溶剂中反应来解决。 特别是通过使用沸点为100℃以上的醇作为溶剂，可以提高上述络合物的收率。

公开(公告)号：US20120172601A1

公开(公告)日：2012-07-05

申请号：US13395312

申请日：2010-05-31

申请人： Yoshimasa Matsushima ,  Hideki Nara ,  Takahiro Fujiwara

发明人： Yoshimasa Matsushima ,  Hideki Nara ,  Takahiro Fujiwara

IPC分类号： C07F3/06 ,  C07C67/08 ,  C07F7/18 ,  C07C229/34 ,  C07D211/46 ,  C07D263/12 ,  C07C67/03

CPC分类号： C07D211/46 ,  B01J31/2239 ,  B01J2231/349 ,  B01J2531/0219 ,  B01J2531/26 ,  C07B41/12 ,  C07C53/18 ,  C07C67/03 ,  C07C67/08 ,  C07C269/06 ,  C07C2601/14 ,  C07D263/12 ,  C07D309/12 ,  C07F3/003 ,  C07C69/612 ,  C07C271/22

摘要： Disclosed is a novel zinc cluster compound represented by general formula (1): Zn4O (OCOR)6 (RCOOH)n, wherein R represents an alkyl group which has 1 to 4 carbon atoms and may be substituted with a halogen atom, and n represents 0.1 to 1, and also disclosed are a method for producing the compound and a reaction using the compound.

摘要翻译： 公开了由通式（1）表示的新型锌簇化合物：Zn 4 O（OCOR）6（RCOOH）n，其中R表示具有1至4个碳原子并可被卤素原子取代的烷基，n表示 0.1〜1，也公开了使用该化合物的化合物的制造方法和反应。

公开(公告)号：US20100200185A1

公开(公告)日：2010-08-12

申请号：US12670186

申请日：2008-03-06

申请人： Kazunari Sakai ,  Takahiro Fujiwara ,  Kazushige Inaoka

发明人： Kazunari Sakai ,  Takahiro Fujiwara ,  Kazushige Inaoka

IPC分类号： D21H17/45 ,  C08F212/08 ,  C08F220/10 ,  C08F220/60 ,  C08F220/06 ,  C08F228/02 ,  D21H17/37

CPC分类号： D21H21/16 ,  D21H17/41 ,  D21H17/455 ,  D21H17/675

摘要： To provide a papermaking internal sizing agent capable of efficiently imparting sizing performance even in neutral papermaking which uses calcium carbonate as filler, and uses no aluminum sulfate or uses a small amount of aluminum sulfate, and also provide a paper or a paperboard obtained by using the papermaking internal sizing agent. The papermaking internal sizing agent comprises as an effective ingredient an amphoteric copolymer having hydrophobic groups and cationic groups, at least a part of the cationic groups being quaternized. Preferably, the amphoteric copolymer is obtained by polymerizing monomer ingredients that it essentially contain a hydrophobic monomer (A), a cationic monomer (B), and an anionic monomer (C) and that an anion equivalent of the monomer (C) is 0.1 to 90% of a cation equivalent of the monomer (B), in which a rate of quaternizing of the cationic groups is not less than 40% by mole. The paper or the paperboard contains the above papermaking internal sizing agent.

摘要翻译： 提供即使在使用碳酸钙作为填料的中性造纸中也能有效赋予施胶性能，不使用硫酸铝或使用少量硫酸铝的造纸内施胶剂，并且还提供通过使用碳酸钙作为填料获得的纸或纸板 造纸内部施胶剂。 造纸内部施胶剂包括具有疏水基团和阳离子基团的两性共聚物作为有效成分，至少一部分阳离子基团被季铵化。 优选地，两性共聚物通过使其基本上含有疏水单体（A），阳离子单体（B）和阴离子单体（C）的单体成分聚合而获得，并且单体（C）的阴离子当量为0.1〜 单体（B）的阳离子当量的90％，其中阳离子基团的季铵化率不低于40摩尔％。 纸或纸板包含上述造纸内部施胶剂。

公开(公告)号：US20100076210A1

公开(公告)日：2010-03-25

申请号：US12540794

申请日：2009-08-13

申请人： Hideki Nara ,  Noboru Sayo ,  Takahiro Fujiwara

发明人： Hideki Nara ,  Noboru Sayo ,  Takahiro Fujiwara

IPC分类号： C07F15/00

CPC分类号： C07F15/0053

摘要： Provided is a method for producing a ruthenium complex comprises the step of reacting a ruthenium compound represented by general formula (1): [RuX(L)(PP)]X   (1), wherein Ru represents a ruthenium atom; X represents a halogen atom; L represents an arene; and PP represents an optically active bisphosphine, with a carboxylate salt represented by general formula (2): R1CO2M   (2), wherein M represents a monovalent cation; and R1 represents a group selected from the group consisting of alkyl groups, haloalkyl groups, phenyl groups optionally having a substituent(s), 1-aminoalkyl groups and 1-amino-1-phenylalkyl groups, to produce a ruthenium complex represented by general formula (3): Ru(OCOR1)2(PP)   (3), wherein R1 represents the group selected from the group consisting of alkyl groups, haloalkyl groups, phenyl groups optionally having a substituent(s), 1-aminoalkyl groups and 1-amino-1-phenylalkyl groups; and PP represents the optically active bisphosphine.

摘要翻译： 提供一种制备钌络合物的方法，包括使通式（1）表示的钌化合物：[RuX（L）（PP）] X（1），其中Ru表示钌原子; X表示卤原子; L代表芳烃; 和PP代表光学活性双膦，与通式（2）表示的羧酸盐：R1CO2M（2），其中M表示一价阳离子; 并且R 1表示选自烷基，卤代烷基，任选具有取代基的苯基，1-氨基烷基和1-氨基-1-苯基烷基的基团，以制备由通式 （3）：Ru（OCOR1）2（PP）（3），其中R1表示选自烷基，卤代烷基，任选具有取代基的苯基，1-氨基烷基和1- 氨基-1-苯基烷基; PP代表光学活性双膦。

公开(公告)号：US07312347B2

公开(公告)日：2007-12-25

申请号：US11526252

申请日：2006-09-22

申请人： Takahiro Fujiwara ,  Tohru Yokozawa

发明人： Takahiro Fujiwara ,  Tohru Yokozawa

IPC分类号： C07F15/00 ,  C07F9/02

CPC分类号： C07F9/65517

摘要： Provided is a method for producing an optically active compound, in more detail, for producing an optically active compound by asymmetric hydrogenation in a high yield and asymmetric yield. The present invention also provides a catalyst for asymmetric synthesis for the above production method, especially a catalyst for asymmetric hydrogenation, containing a transition metal complex. Further, the present invention provides a new diphosphine compound useful as a ligand of the above transition metal complex and a new transition metal complex containing the above diphosphine compound.The present invention relates to a diphosphine compound represented by the following formula (1): a transition metal complex using the compound, a catalyst for asymmetric synthesis comprising the above transition metal complex and a method for producing an optically active compound using the above catalyst for asymmetric synthesis.

公开(公告)号：US20070142472A1

公开(公告)日：2007-06-21

申请号：US10578744

申请日：2004-11-26

申请人： Tohru Yokozawa ,  Hideo Shimizu ,  Takahiro Fujiwara ,  Yasunori Ino

发明人： Tohru Yokozawa ,  Hideo Shimizu ,  Takahiro Fujiwara ,  Yasunori Ino

IPC分类号： A61K31/192 ,  C07C65/03

CPC分类号： C07C51/412 ,  C07C51/09 ,  C07C51/36 ,  C07C51/43 ,  Y02P20/55 ,  C07C59/64

摘要： The present invention relates to a process for producing an optically active 3-(4-hydroxyphenyl)propionic acid useful as intermediates for medicines, through short steps in good yield and with high optical purity. More specifically, the present invention relates to a process for producing an optically active 3-(4-hydroxyphenyl)propionic acid of the formula (6): wherein R2 is an alkyl group; R5 to R8 are each independently a hydrogen atom or a substituent; and the symbol * is an chiral carbon atom, or a salt thereof, which comprises reacting a benzaldehyde of the formula (1): wherein R1 is a protective group; and R5 to R8 are each the same as defined above, with a glycolic acid derivative of the formula (2): wherein R3 is a hydrocarbon group; and R2 is the same as defined above, hydrolyzing the resulting product to give a cinnamic acid of the formula (4): wherein R1, R2 and R5 to R8 are each the same as defined above, or a salt thereof, and subjecting the resulting cinnamic acid (4) or a salt thereof to asymmetric hydrogenation to give an optically active phenylpropionic acid of the formula (5): wherein all the symbols are each the same as defined above, or a salt thereof, followed by deprotection.

摘要翻译： 本发明涉及一种用作药物中间体的光学活性3-（4-羟基苯基）丙酸的方法，通过短的步骤以良好的收率和高的光学纯度。 更具体地说，本发明涉及制备式（6）的光学活性3-（4-羟基苯基）丙酸的方法：其中R 2是烷基; R 5至R 8各自独立地为氢原子或取代基; 符号*是手性碳原子或其盐，其包括使式（1）的苯甲醛：其中R 1为保护基; 和R 5至R 8各自与上述定义相同，与式（2）的乙醇酸衍生物：其中R 3， 是一个烃基; 和R 2与上述定义相同，水解所得产物，得到式（4）的肉桂酸：其中R 1，R 2， R 0和R 5至R 8各自与上述定义相同，或其盐，并将所得肉桂酸（4）或其盐 不对称氢化得到式（5）的光学活性苯基丙酸：其中所有符号各自与上述定义相同，或其盐，然后脱保护。

公开(公告)号：US5601228A

公开(公告)日：1997-02-11

申请号：US501085

申请日：1995-08-02

申请人： Takao Fukunaga ,  Kazuhito Higasa ,  Hirokazu Shiroishi ,  Seishi Kumamoto ,  Takahiro Fujiwara ,  Noriko Katayama

发明人： Takao Fukunaga ,  Kazuhito Higasa ,  Hirokazu Shiroishi ,  Seishi Kumamoto ,  Takahiro Fujiwara ,  Noriko Katayama

IPC分类号： B23K35/02 ,  B23K35/26 ,  B23K35/34 ,  H05K3/34

CPC分类号： B23K35/025 ,  B23K35/262 ,  B23K35/268 ,  B23K35/34 ,  H05K3/3484 ,  H05K2203/125 ,  Y10T29/49144

摘要： The invention provides a solder-precipitating composition containing Sn-Pb alloy powder and an organic acid salt of Pb as essential components, and capable of precipitating solder as a result of substitution between Sn contained in the Sn-Pb alloy powder and Pb contained in the organic acid salt of Pb. Further, the invention provides a mounting method including the steps of supplying a conductor on a board with a solder-precipitating composition which contains Sn-Pb alloy powder and an organic acid salt of Pb as essential components, heating the solder-precipitating composition supplied on the conductor, to precipitate solder on the conductor and pre-coat the conductor with solder, as a result of substitution reaction between Sn in the Sn-Pb alloy powder and Pb ions in the organic acid salt of Pb, mounting a device on the solder pre-coated conductor, and melting the solder layer to securely mount the device on the conductor.

摘要翻译： PCT No.PCT / JP94 / 02047 Sec。 371日期：1995年8月2日 102（e）日期1995年8月2日PCT 1994年12月6日PCT PCT。 出版物WO95 / 15834 日期：1995年6月15日本发明提供了含有Sn-Pb合金粉末和Pb的有机酸盐作为必要成分的焊料沉淀组合物，并且能够通过Sn-Pb合金粉末中包含的Sn的取代而使焊料沉淀 和Pb中有机酸盐中含有的Pb。 此外，本发明提供了一种安装方法，包括以下步骤：在板上提供含有Sn-Pb合金粉末和Pb的有机酸盐作为必需组分的焊料沉淀组合物，加热供给的焊料沉淀组合物 导体，通过Sn-Pb合金粉末中的Sn和Pb的有机酸盐中的Pb离子之间的取代反应，将焊料沉淀在导体上并用焊料预先涂覆导体，将装置安装在焊料上 预涂导体，并熔化焊料层，以将装置牢固地安装在导体上。

公开(公告)号：US5453582A

公开(公告)日：1995-09-26

申请号：US396867

申请日：1995-03-01

申请人： Toshiaki Amano ,  Kazuhito Hikasa ,  Seishi Kumamoto ,  Takahiro Fujiwara

发明人： Toshiaki Amano ,  Kazuhito Hikasa ,  Seishi Kumamoto ,  Takahiro Fujiwara

IPC分类号： B23K35/00 ,  B23K35/34 ,  H05K1/11 ,  H05K3/34 ,  H05K1/18

CPC分类号： H05K3/3421 ,  B23K35/34 ,  H05K1/111 ,  B23K35/007 ,  H05K2201/09381 ,  H05K2201/097 ,  H05K2201/10689 ,  H05K2203/042 ,  H05K2203/1157 ,  H05K2203/125 ,  H05K3/3484 ,  Y02P70/611 ,  Y02P70/613

摘要： A large number of pads, to which component leads are to be soldered, are formed on an insulating substrate so as to constitute a pad array. Colder layers are precoated on the pads. Each of the pads has a component lead mounting portion where a component lead is to be mounted, and a component lead non-mounting portion where no component lead is to be mounted. The component lead non-mounting portion includes a wide part having a width greater than that of the component lead mounting portion.

摘要翻译： 为了构成焊盘阵列，在绝缘基板上形成有要焊接有组分引线的大量焊盘。 更硬的层预涂在垫上。 每个焊盘具有要安装部件引线的部件引线安装部分和不安装部件引线的部件引线非安装部分。 部件引线非安装部分包括具有大于部件引线安装部分的宽度的宽部分。

公开(公告)号：US08551908B2

公开(公告)日：2013-10-08

申请号：US13001683

申请日：2009-06-26

申请人： Akemi Satou ,  Masahiko Takeuchi ,  Keizo Hiraku ,  Yusuke Kawamura ,  Takahiro Fujiwara ,  Tadashi Suzuki ,  Naoki Takahashi

发明人： Akemi Satou ,  Masahiko Takeuchi ,  Keizo Hiraku ,  Yusuke Kawamura ,  Takahiro Fujiwara ,  Tadashi Suzuki ,  Naoki Takahashi

IPC分类号： B01J23/00 ,  B01J21/00

CPC分类号： B01J23/002 ,  B01D53/945 ,  B01D2255/1021 ,  B01D2255/1023 ,  B01D2255/1025 ,  B01D2255/206 ,  B01D2255/20715 ,  B01D2255/9022 ,  B01D2255/908 ,  B01D2257/304 ,  B01J23/63 ,  B01J23/83 ,  B01J23/894 ,  B01J35/04 ,  B01J37/0244 ,  B01J2523/00 ,  Y02T10/22 ,  B01J2523/3712 ,  B01J2523/3718 ,  B01J2523/48 ,  B01J2523/828 ,  B01J2523/824 ,  B01J2523/822

摘要： An exhaust gas purification catalyst includes: a lower catalyst layer that contains a ceria-zirconia mixed oxide having 50 to 70 mass % of CeO2 and 5 mass % or more of Pr2O3 and carries at least one of Pt and Pd; and an upper catalyst layer that contains at least zirconia and carries at least Rh, wherein the total amount of CeO2 per liter of the carrier base is 15 to 30 g. Because the amount of CeO2 is small, formation of H2S is suppressed and a high capability of adsorbing and releasing oxygen is brought out in spite of the small amount of CeO2.

摘要翻译： 废气净化催化剂包括：含有氧化铈 - 氧化锆混合氧化物的下部催化剂层，其具有50〜70质量％的CeO 2和5质量％以上的Pr 2 O 3，并携带Pt和Pd中的至少一种; 和至少含有氧化锆并至少含有Rh的上部催化剂层，其中每升载体碱的CeO 2的总量为15〜30g。 由于CeO 2的量少，因此抑制了H 2 S的形成，并且尽管CeO 2的量少，但是吸附和释放氧的能力也很高。

公开(公告)号：US20120309937A1

公开(公告)日：2012-12-06

申请号：US13515970

申请日：2010-12-14

申请人： Hideyoshi Harashima ,  Takahiro Fujiwara ,  Hidetaka Akita

发明人： Hideyoshi Harashima ,  Takahiro Fujiwara ,  Hidetaka Akita

IPC分类号： C07K1/113 ,  C07K1/107

CPC分类号： C07K7/06 ,  A61K9/1271 ,  A61K38/00 ,  A61K47/60 ,  A61K47/62 ,  A61K47/6911

摘要： Provided are peptides imparting cell permeability to a lipid membrane structure and/or enhancing the cell permeability of a lipid membrane structure, and a lipid membrane structure which comprises, as a constituent lipid, a lipid bound to such a peptide and has cell permeability or shows enhanced cell permeability. The amino acid sequences of the peptides imparting cell permeability to a lipid membrane structure and/or enhancing the cell permeability of a lipid membrane structure are represented by: LX1X2X1X1X1L, LLX2X1X1X1L and LX1X2X1X1L (wherein L represents a leucine residue; X1 represents a polar amino acid residue; and X2 represents a polar, non-charged and branched chain amino acid residue).

摘要翻译： 提供赋予脂质膜结构的细胞渗透性和/或增强脂质膜结构的细胞渗透性的肽，以及脂质膜结构，其包含作为构成脂质的与这种肽结合的脂质并具有细胞渗透性或显示 增强细胞渗透性。 赋予细胞对脂质膜结构的渗透性和/或增强脂质膜结构的细胞渗透性的肽的氨基酸序列由以下表示：LX1X2X1X1X1L，LLX2X1X1X1L和LX1X2X1X1L（其中L表示亮氨酸残基; X1表示极性氨基酸 残基; X2表示极性，非带电荷和支链氨基酸残基）。