-
1.发明授权公开(公告)号：US07973044B2
公开(公告)日：2011-07-05
申请号：US12645154
申请日：2009-12-22
Applicant: Andrei W. Konradi , Michael A. Pleiss , Eugene D. Thorsett , Susan Ashwell , Gregory S. Welmaker , Anthony Kreft , Dimitrios Sarantakis , Darren B. Dressen , Francine S. Grant , Christopher Semko , Ying-Zi Xu
Inventor： Andrei W. Konradi , Michael A. Pleiss , Eugene D. Thorsett , Susan Ashwell , Gregory S. Welmaker , Anthony Kreft , Dimitrios Sarantakis , Darren B. Dressen , Francine S. Grant , Christopher Semko , Ying-Zi Xu
IPC: A01N43/54 , C07D239/42
CPC classification number: A61K31/425 , A61K31/41 , A61K31/427 , A61K31/433 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/535 , A61K31/54 , C07D211/58 , C07D213/74 , C07D213/76 , C07D233/88 , C07D239/32 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/52 , C07D241/20 , C07D249/06 , C07D251/18 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/54 , C07D257/06 , C07D285/06 , C07D285/10 , C07D333/36 , C07D333/48 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , Y02A50/463 , A61K2300/00
Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
-
2.发明授权Alpha amino acid derivatives-inhibitors of leukocyte adhesion mediated by VLA-4 有权α氨基酸衍生物 - 由VLA-4介导的白细胞粘附抑制剂公开(公告)号：US07745454B2
公开(公告)日：2010-06-29
申请号：US10936070
申请日：2004-09-07
Applicant: Andrei W. Konradi , Michael A. Pleiss , Eugene D. Thorsett , Susan Ashwell , Gregory S. Welmaker , Anthony Kreft , Dimitrios Sarantakis , Darren B. Dressen , Francine S. Farouz , Christopher M. Semko , Ying-Zi Xu
Inventor： Andrei W. Konradi , Michael A. Pleiss , Eugene D. Thorsett , Susan Ashwell , Gregory S. Welmaker , Anthony Kreft , Dimitrios Sarantakis , Darren B. Dressen , Francine S. Farouz , Christopher M. Semko , Ying-Zi Xu
IPC: A61K31/505 , A61K31/515 , C07D239/22 , C07D239/42 , A61P19/02 , A61P11/06 , A61P37/08
CPC classification number: C07D401/12 , C07D239/48 , C07D239/52 , C07D417/12
Abstract: Disclosed are certain alpha amino acid compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
Abstract translation: 公开了结合VLA-4的某些α氨基酸化合物。 这些化合物中的某些也抑制白细胞粘附，特别是由VLA-4介导的白细胞粘附。 这样的化合物可用于治疗哺乳动物患者，例如人类例如哮喘，阿尔茨海默氏病，动脉粥样硬化，艾滋病痴呆，糖尿病，炎性肠病，类风湿性关节炎，组织移植，肿瘤转移和心肌缺血等炎性疾病。 化合物也可以用于治疗炎性脑疾病如多发性硬化症。
-
公开(公告)号：US20090054396A1
公开(公告)日：2009-02-26
申请号：US12206317
申请日：2008-09-08
Applicant: Susan Ashwell , Thomas Gero , Stephanos Ioannidis , James Janetka , Paul Lyne , Vibha Oza , Mei Su , Dingwei Yu , Stephanie Springer
Inventor： Susan Ashwell , Thomas Gero , Stephanos Ioannidis , James Janetka , Paul Lyne , Vibha Oza , Mei Su , Dingwei Yu , Stephanie Springer
IPC: A61K31/397 , C07D409/02 , C07D333/36 , C07D205/04 , C07D453/02 , A61K31/4406 , A61K31/395 , A61K31/381 , A61P35/00 , A61K31/496 , A61K31/551 , C07D243/08 , C07D221/02 , C07D401/02
CPC classification number: C07D333/68 , C07D333/38 , C07D409/12 , C07D409/14 , C07D453/02 , C07D453/06
Abstract: This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical salts, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
Abstract translation: 本发明涉及具有结构式（I）的新化合物及其药物盐，组合物和使用方法。 这些新化合物提供癌症的治疗或预防。
-
4.发明申请3-(HETEROARYL)ALANINE DERIVATIVES-INHIBITORS OF LEUKOCYTE ADHESION MEDIATED BY VLA-4 审中-公开VLA-4介导的紫外线粘合剂的3-（异氟醚）胺衍生物抑制剂公开(公告)号：US20080182850A1
公开(公告)日：2008-07-31
申请号：US11873358
申请日：2007-10-16
Applicant: Andrei W. Konradi , Michael A. Pleiss , Eugene D. Thorsett , Susan Ashwell , Gregory S. Welmaker , Anthony Kreft , Dimitrios Sarantakis , Darren B. Dressen , Francine S. Grant , Christopher Semko , Ying-Zi Xu , Frank Stappenbeck
Inventor： Andrei W. Konradi , Michael A. Pleiss , Eugene D. Thorsett , Susan Ashwell , Gregory S. Welmaker , Anthony Kreft , Dimitrios Sarantakis , Darren B. Dressen , Francine S. Grant , Christopher Semko , Ying-Zi Xu , Frank Stappenbeck
IPC: A61K31/41 , C07D403/02 , A61K31/435 , A61K31/501 , A61K31/504
CPC classification number: C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D417/14
Abstract: Disclosed are certain 3-(heteroaryl)alanine derivatives which bind VLA-4 and inhibit leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
Abstract translation: 公开了结合VLA-4并抑制由VLA-4介导的白细胞粘附的某些3-（杂芳基）丙氨酸衍生物。 这样的化合物可用于治疗哺乳动物患者，例如人类例如哮喘，阿尔茨海默氏病，动脉粥样硬化，艾滋病痴呆，糖尿病，炎性肠病，类风湿性关节炎，组织移植，肿瘤转移和心肌缺血等炎性疾病。 化合物也可以用于治疗炎性脑疾病如多发性硬化症。
-
公开(公告)号：US20070149560A1
公开(公告)日：2007-06-28
申请号：US10549053
申请日：2004-03-10
Applicant: Susan Ashwell , Jayachandran Ezhuthachan , Paul Lyne , Nicholas Newcombe , Martin Pass , Vibha Oza , Mei Su , Dorin Toader , Dingwei Yu , Yan Yu
Inventor： Susan Ashwell , Jayachandran Ezhuthachan , Paul Lyne , Nicholas Newcombe , Martin Pass , Vibha Oza , Mei Su , Dorin Toader , Dingwei Yu , Yan Yu
IPC: A61K31/4745 , C07D487/02
CPC classification number: C07D471/04 , A61K31/4196
Abstract: This invention relates to novel compounds having the structural diagram (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
Abstract translation: 本发明涉及具有结构图（I）及其药物组合物及其使用方法的新型化合物。 这些新化合物提供癌症的治疗或预防。
-
Patent Agency Ranking
6.发明申请公开(公告)号：US20050203093A1
公开(公告)日：2005-09-15
申请号：US11033079
申请日：2005-01-10
Applicant: Andrei Konradi , Michael Pleiss , Eugene Thorsett , Susan Ashwell , Gregory Welmaker , Anthony Kreft , Dimitrios Sarantakis , Darren Dressen , Francine Grant , Christopher Semko , Ying-Zi Xu
Inventor： Andrei Konradi , Michael Pleiss , Eugene Thorsett , Susan Ashwell , Gregory Welmaker , Anthony Kreft , Dimitrios Sarantakis , Darren Dressen , Francine Grant , Christopher Semko , Ying-Zi Xu
IPC: C07D239/42 , A61K31/33 , A61K31/38 , A61K31/381 , A61K31/41 , A61K31/415 , A61K31/425 , A61K31/427 , A61K31/433 , A61K31/435 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/4468 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/535 , A61K31/54 , A61K38/00 , A61P1/00 , A61P3/10 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P25/00 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P35/04 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D20060101 , C07D211/58 , C07D213/74 , C07D213/76 , C07D231/38 , C07D233/66 , C07D233/88 , C07D237/02 , C07D239/02 , C07D239/46 , C07D239/48 , C07D239/52 , C07D241/20 , C07D249/06 , C07D251/18 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/54 , C07D257/06 , C07D285/10 , C07D295/22 , C07D333/36 , C07D333/48 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D521/00
CPC classification number: A61K31/425 , A61K31/41 , A61K31/427 , A61K31/433 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/535 , A61K31/54 , C07D211/58 , C07D213/74 , C07D213/76 , C07D233/88 , C07D239/32 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/52 , C07D241/20 , C07D249/06 , C07D251/18 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/54 , C07D257/06 , C07D285/06 , C07D285/10 , C07D333/36 , C07D333/48 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , Y02A50/463 , A61K2300/00
Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
-
7.发明授权Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4 失效抑制由VLA-4介导的白细胞粘附的杂芳基，杂环和芳基化合物公开(公告)号：US06911439B2
公开(公告)日：2005-06-28
申请号：US10218366
申请日：2002-08-15
Applicant: Andrei W. Konradi , Michael A. Pleiss , Eugene D. Thorsett , Susan Ashwell , Gregory S. Welmaker , Anthony Kreft , Dimitrios Sarntakis , Darren B. Dressen , Francine S. Grant , Christopher Semko , Ying-Zi Xu
Inventor： Andrei W. Konradi , Michael A. Pleiss , Eugene D. Thorsett , Susan Ashwell , Gregory S. Welmaker , Anthony Kreft , Dimitrios Sarntakis , Darren B. Dressen , Francine S. Grant , Christopher Semko , Ying-Zi Xu
IPC: C07D239/42 , A61K31/33 , A61K31/38 , A61K31/381 , A61K31/41 , A61K31/415 , A61K31/425 , A61K31/427 , A61K31/433 , A61K31/435 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/4468 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/535 , A61K31/54 , A61K38/00 , A61P1/00 , A61P3/10 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P25/00 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P35/04 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D20060101 , C07D211/58 , C07D213/74 , C07D213/76 , C07D231/38 , C07D233/66 , C07D233/88 , C07D237/02 , C07D239/02 , C07D239/46 , C07D239/48 , C07D239/52 , C07D241/20 , C07D249/06 , C07D251/18 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/54 , C07D257/06 , C07D285/10 , C07D295/22 , C07D333/36 , C07D333/48 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D521/00
CPC classification number: A61K31/425 , A61K31/41 , A61K31/427 , A61K31/433 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/535 , A61K31/54 , C07D211/58 , C07D213/74 , C07D213/76 , C07D233/88 , C07D239/32 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/52 , C07D241/20 , C07D249/06 , C07D251/18 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/54 , C07D257/06 , C07D285/06 , C07D285/10 , C07D333/36 , C07D333/48 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , Y02A50/463 , A61K2300/00
Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
Abstract translation: 公开了结合VLA-4的化合物。 这些化合物中的某些也抑制白细胞粘附，特别是由VLA-4介导的白细胞粘附。 这样的化合物可用于治疗哺乳动物患者，例如人类例如哮喘，阿尔茨海默氏病，动脉粥样硬化，艾滋病痴呆，糖尿病，炎性肠病，类风湿性关节炎，组织移植，肿瘤转移和心肌缺血等炎性疾病。 化合物也可以用于治疗炎性脑疾病如多发性硬化症。
-
8.发明授权Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4 失效抑制由VLA-4介导的白细胞粘附的氨基甲酰氧基化合物公开(公告)号：US06900179B2
公开(公告)日：2005-05-31
申请号：US09987619
申请日：2001-11-15
Applicant: Eugene D. Thorsett , Christopher M. Semko , Dimitrios Sarantakis , Michael A. Pleiss , Anthony Kreft , Andrei W. Konradi , Francine S. Grant , Darren B. Dressen , Susan Ashwell , Reinhardt Bernhard Baudy , Louis John Lombardo
Inventor： Eugene D. Thorsett , Christopher M. Semko , Dimitrios Sarantakis , Michael A. Pleiss , Anthony Kreft , Andrei W. Konradi , Francine S. Grant , Darren B. Dressen , Susan Ashwell , Reinhardt Bernhard Baudy , Louis John Lombardo
IPC: A61K31/397 , A61K31/4015 , A61K31/404 , A61K31/495 , A61K31/54 , A61K38/00 , C07K5/02 , C07K5/06 , C07K5/078
CPC classification number: A61K31/397 , A61K31/4015 , A61K31/404 , A61K31/495 , A61K31/54 , A61K38/00 , C07K5/0215 , C07K5/06026 , C07K5/06139 , C07K5/06165 , C07K5/06191
Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
Abstract translation: 公开了结合VLA-4的化合物。 这些化合物中的某些也抑制白细胞粘附，特别是由VLA-4介导的白细胞粘附。 这样的化合物可用于治疗哺乳动物患者（例如人，例如哮喘，阿尔茨海默病，动脉粥样硬化，AIDS痴呆，糖尿病，炎性肠病，类风湿性关节炎，组织移植，肿瘤转移和心肌缺血）中的炎性疾病。 化合物也可以用于治疗炎性脑疾病如多发性硬化症。
-
9.发明授权Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4 有权抑制由VLA-4介导的白细胞粘附的杂芳基，杂环和芳基化合物公开(公告)号：US06492372B1
公开(公告)日：2002-12-10
申请号：US09489377
申请日：2000-01-21
Applicant: Andrei W. Konradi , Michael A. Pleiss , Eugene D. Thorsett , Susan Ashwell , Gregory S. Welmaker , Anthony Kreft , Dimitrios Sarantakis , Darren B. Dressen , Francine S. Grant , Christopher Semko , Ying-Zi Xu
Inventor： Andrei W. Konradi , Michael A. Pleiss , Eugene D. Thorsett , Susan Ashwell , Gregory S. Welmaker , Anthony Kreft , Dimitrios Sarantakis , Darren B. Dressen , Francine S. Grant , Christopher Semko , Ying-Zi Xu
IPC: A61K3133
CPC classification number: A61K31/425 , A61K31/41 , A61K31/427 , A61K31/433 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/535 , A61K31/54 , C07D211/58 , C07D213/74 , C07D213/76 , C07D233/88 , C07D239/32 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/52 , C07D241/20 , C07D249/06 , C07D251/18 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/54 , C07D257/06 , C07D285/06 , C07D285/10 , C07D333/36 , C07D333/48 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , Y02A50/463 , A61K2300/00
Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
Abstract translation: 公开了结合VLA-4的化合物。 这些化合物中的某些也抑制白细胞粘附，特别是由VLA-4介导的白细胞粘附。 这样的化合物可用于治疗哺乳动物患者，例如人类例如哮喘，阿尔茨海默氏病，动脉粥样硬化，艾滋病痴呆，糖尿病，炎性肠病，类风湿性关节炎，组织移植，肿瘤转移和心肌缺血等炎性疾病。 化合物也可以用于治疗炎性脑疾病如多发性硬化症。
-
10.发明授权Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4 失效抑制由VLA-4介导的白细胞粘附的杂芳基，杂环和芳基化合物公开(公告)号：US07378529B2
公开(公告)日：2008-05-27
申请号：US11033079
申请日：2005-01-10
Applicant: Andrei W. Konradi , Michael A. Pleiss , Eugene D. Thorsett , Susan Ashwell , Gregory S. Welmaker , Anthony Kreft , Dimitrios Sarantakis , Darren B. Dressen , Francine S. Grant , Christopher Semko , Ying-Zi Xu
Inventor： Andrei W. Konradi , Michael A. Pleiss , Eugene D. Thorsett , Susan Ashwell , Gregory S. Welmaker , Anthony Kreft , Dimitrios Sarantakis , Darren B. Dressen , Francine S. Grant , Christopher Semko , Ying-Zi Xu
IPC: C07D285/10 , C07D271/00 , A01N43/64 , A61K31/41
CPC classification number: A61K31/425 , A61K31/41 , A61K31/427 , A61K31/433 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/535 , A61K31/54 , C07D211/58 , C07D213/74 , C07D213/76 , C07D233/88 , C07D239/32 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/52 , C07D241/20 , C07D249/06 , C07D251/18 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/54 , C07D257/06 , C07D285/06 , C07D285/10 , C07D333/36 , C07D333/48 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , Y02A50/463 , A61K2300/00
Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
Abstract translation: 公开了结合VLA-4的化合物。 这些化合物中的某些也抑制白细胞粘附，特别是由VLA-4介导的白细胞粘附。 这样的化合物可用于治疗哺乳动物患者，例如人类例如哮喘，阿尔茨海默氏病，动脉粥样硬化，艾滋病痴呆，糖尿病，炎性肠病，类风湿性关节炎，组织移植，肿瘤转移和心肌缺血等炎性疾病。 化合物也可以用于治疗炎性脑疾病如多发性硬化症。
-
-
-
-
-
-
-
-
-
Search Results
36
records
(took 0.037 seconds)
