公开(公告)号：US20250066342A1

公开(公告)日：2025-02-27

申请号：US18926869

申请日：2024-10-25

Applicant: Sumitomo Pharma Co., Ltd.

Inventor： Eiji IDEUE ,  Masafumi KOMIYA ,  Shoukou LEE ,  Shunichiro UESUGI ,  Yuta FUNAKOSHI

IPC: C07D413/14 ,  A61P25/26 ,  C07D401/12 ,  C07D487/08

Abstract: The present invention relates to a medicament for treating or preventing a disease related to orexin receptor, especially orexin type 2 receptor, comprising a new compound having a urea structure or a pharmaceutically acceptable salt thereof as an active ingredient. In more detail, the present invention relates to a medicament for treating or preventing narcolepsy, idiopathic hypersomnia, hypersomnia, sleep apnea syndrome, etc.

公开(公告)号：US12162872B2

公开(公告)日：2024-12-10

申请号：US17610291

申请日：2020-11-26

Applicant: Sumitomo Pharma Co., Ltd.

Inventor： Eiji Ideue ,  Masafumi Komiya ,  Shoukou Lee ,  Shunichiro Uesugi ,  Yuta Funakoshi

IPC: C07D413/14 ,  A61P25/26 ,  C07D401/12 ,  C07D487/08

Abstract: The present invention relates to a medicament for treating or preventing a disease related to orexin receptor, especially orexin type 2 receptor, comprising a new compound having a urea structure or a pharmaceutically acceptable salt thereof as an active ingredient. In more detail, the present invention relates to a medicament for treating or preventing narcolepsy, idiopathic hypersomnia, hypersomnia, sleep apnea syndrome, etc.

公开(公告)号：US20240400983A1

公开(公告)日：2024-12-05

申请号：US18697382

申请日：2022-09-27

Applicant: Sumitomo Pharma Co., Ltd. ,  National University Corporation Tokai National Higher Education and Research System ,  SUMITOMO CHEMICAL COMPANY, LIMITED

Inventor： Shiori TAGA ,  Atsushi KUWAHARA ,  Hidetaka SUGA ,  Tokushige NAKANO

IPC: C12N5/071

Abstract: The present invention provides a method for efficiently producing a cell aggregate containing pituitary hormone-producing cells from pluripotent stem cells.

公开(公告)号：US12150941B2

公开(公告)日：2024-11-26

申请号：US18120519

申请日：2023-03-13

Applicant: Sumitomo Pharma Co., Ltd.

Inventor： Yohei Ikuma ,  Kengo Tojo ,  Ryo Fukazawa ,  Shuji Masumoto

IPC: C07D487/04 ,  A61K31/4985 ,  A61P25/28 ,  C07D519/00

Abstract: A process for preparing a compound of Formula (1a): or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240382132A1

公开(公告)日：2024-11-21

申请号：US18690010

申请日：2022-09-06

Applicant: Sumitomo Pharma Co., Ltd.

Inventor： Minoru YOSHIMIZU ,  Yasushi OCHIAI ,  Sadao MASAYOSHI

IPC: A61B5/291 ,  A61B5/00 ,  A61B5/254 ,  A61B5/256

Abstract: An object of the present invention is to provide a wearable brain wave measurement device having a structure that can achieve both of improvement of durability and improvement of fitting feeling in order to contribute to improvement of the quality of a brain wave signal to be measured. The present invention provides a brain wave measurement device wearable on a living body head, the brain wave measurement device including a housing unit including at least a central front-side component, a left front-side component, a right front side component, and a rear-side component, the housing unit having a curved shape such that the housing unit is disposed along the living body head from a left temporal region through a frontal region to a right temporal region at a time of wearing, at least one measurement electrode that is fixed to the rear-side component and comes into contact with the frontal region at the time of wearing, and a signal processing unit housed in the housing unit, the signal processing unit processing an electric signal obtained via the measurement electrode. Rigidities of at least two components among the central front-side component, the left front-side component, the right front-side component, and the rear-side component are different from each other.

公开(公告)号：US20240279602A1

公开(公告)日：2024-08-22

申请号：US18569736

申请日：2022-06-16

Applicant: Kyoto University ,  Sumitomo Pharma Co., Ltd.

Inventor： Jun TAKAHASHI ,  Daisuke DOI ,  Megumi IKEDA

IPC: C12N5/0793 ,  A61K35/30 ,  C12Q1/68

CPC classification number: C12N5/0619 ,  A61K35/30 ,  C12Q1/68 ,  C12N2500/38 ,  C12N2501/01 ,  C12N2501/13 ,  C12N2506/45

Abstract: The present disclosure provides a cerebral organoid derived from a human pluripotent stem cell, a cell aggregate including a cerebral cortical cell, and a method for producing any of them, each being useful for regenerative therapy.

公开(公告)号：US20240252544A1

公开(公告)日：2024-08-01

申请号：US18290392

申请日：2022-05-13

Applicant: RIKEN ,  Sumitomo Pharma Co., Ltd.

Inventor： Michiko Mandai ,  Suguru Yamasaki

IPC: A61K35/30 ,  C12N5/079

CPC classification number: A61K35/30 ,  C12N5/0618 ,  C12N2501/155 ,  C12N2501/727 ,  C12N2506/02 ,  C12N2513/00 ,  C12N2533/52

Abstract: An object of the present invention is to provide a method for producing a retinal cell or retinal tissue with a reduced proportion of non-target cells in differentiating pluripotent stem cells. The method of the present invention for producing a retinal cell or retinal tissue comprises: (A) suspension-culturing a pluripotent stem cell to form a cell aggregate of pluripotent stem cells; and (B) suspension-culturing the cell aggregate obtained in the step (A) in the presence of a BMP signaling pathway agonist and a CHK1 signaling pathway inhibitor to obtain a cell aggregate containing a retinal cell.

公开(公告)号：US20240150370A1

公开(公告)日：2024-05-09

申请号：US18506804

申请日：2023-11-10

Applicant: Sumitomo Pharma Co., Ltd.

Inventor： Satoshi ADACHI ,  Hidefumi YOSHINAGA ,  Hajime SHIBATA ,  Yusuke SHIODA ,  Riko NAGAHAMA

IPC: C07D491/048 ,  A61P25/00 ,  C07D213/65 ,  C07D215/12 ,  C07D221/04 ,  C07D401/06 ,  C07D471/04 ,  C07D495/04

CPC classification number: C07D491/048 ,  A61P25/00 ,  C07D213/65 ,  C07D215/12 ,  C07D221/04 ,  C07D401/06 ,  C07D471/04 ,  C07D495/04

Abstract: The present disclosure provides bicyclic pyridine derivatives.
A compound represented by formula I:




or a pharmaceutically acceptable salt thereof,

wherein



X is a oxygen atom, sulfur atom, NR, or CR′R″, n is 0 or 1, R1, R2a, R2b, R2c, R2d, R, R′ and R″ are each independently a hydrogen atom, a halogen atom, optionally substituted C1-6 alkyl, or an optionally substituted C6-10 aryl, or two of R2a, R2b, R2c, R2d, R, R′, and R″, together with a carbon atom or a nitrogen atom to which they are attached, form a 3- to 6-membered saturated carbocyclic ring or saturated heterocyclic ring, and R3a, R3b, R3c and R5a and R5b, are as defined in the description.

公开(公告)号：US20240122941A1

公开(公告)日：2024-04-18

申请号：US18258989

申请日：2021-12-24

Applicant: NATIONAL CANCER CENTER ,  Sumitomo Pharma Co., Ltd.

Inventor： Hideaki OGIWARA ,  Mariko SASAKI

IPC: A61K31/553 ,  A61K31/405 ,  A61K31/415 ,  A61K31/4172 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/421 ,  A61K31/426 ,  A61K31/431 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/675 ,  A61P35/00 ,  C12N9/10 ,  C12N9/99

CPC classification number: A61K31/553 ,  A61K31/405 ,  A61K31/415 ,  A61K31/4172 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/421 ,  A61K31/426 ,  A61K31/431 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/675 ,  A61P35/00 ,  C12N9/1025 ,  C12N9/99

Abstract: The present disclosure provides a pharmaceutical composition for treating and/or preventing SWI/SNF complex-dysfunction cancer. More specifically, according to the present disclosure, a compound represented by formulae (1) to (23) (the formulae are as set forth in the specification) or a pharmaceutically acceptable salt thereof can have a therapeutic and/or prophylactic effect on SWI/SNF complex-dysfunction cancer. A pharmaceutical composition, which is for treating and/or preventing cancer and contains a CBP/P300 inhibitor, can be provided. The cancer may be SWI/SNF complex-dysfunction cancer. The SWI/SNF complex-dysfunction cancer may be BAF complex-dysfunction cancer. The BAF complex-dysfunction cancer may be SMARC-deficient cancer, ARID-deficient cancer, or SS18-SSX fusion cancer. The SMARC-deficient cancer may be SMARCB1-deficient cancer, SMARCA2-deficient cancer, SMARCA4-deficient cancer, or SMARCA2/A4-deficient cancer.

公开(公告)号：US20240119684A1

公开(公告)日：2024-04-11

申请号：US18545187

申请日：2023-12-19

Applicant: Pixie Dust Technologies, Inc. ,  Sumitomo Pharma Co., Ltd.

Inventor： Megumi TABATA ,  Haruki NISHIMURA ,  Akira ENDO ,  Yasuhiro HABARA ,  Masaki GOMI ,  Yudai TAIRA

IPC: G06T19/00 ,  G02B27/01 ,  G10L15/26 ,  H04R1/32

CPC classification number: G06T19/006 ,  G02B27/017 ,  G10L15/26 ,  H04R1/32 ,  G02B2027/0178

Abstract: A display control apparatus for controlling display of a display device acquires speech collected by a plurality of microphones and estimates a sound-arrival direction of the acquired speech. Then, the display control apparatus causes a text image corresponding to the acquired speech to be displayed in a predetermined text display area in a display unit of the display device, and causes a symbol image associated with the text image to be displayed at a display position in the display unit, the display position corresponding to the estimated sound-arrival direction.