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    MONOCLONAL ANTIBODY AGAINST NECROSIS MARKER PRDX4 AND USE THEREOF
    3.
    发明申请
    MONOCLONAL ANTIBODY AGAINST NECROSIS MARKER PRDX4 AND USE THEREOF 审中-公开
    单克隆抗体抗体标记PRDX4及其用途

    公开(公告)号：US20160068593A1

    公开(公告)日：2016-03-10

    申请号：US14849742

    申请日：2015-09-10

    申请人： Sumio SUGANO ,  Yukari KANZAKI ,  Tsuneo SAGA ,  Atsushi TSUJI

    发明人： Sumio SUGANO ,  Yukari KANZAKI ,  Tsuneo SAGA ,  Atsushi TSUJI

    IPC分类号： C07K16/18 ,  A61K51/10 ,  G01N33/574

    CPC分类号： G01N33/574 ,  A61K51/1045 ,  A61K51/1093 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/14 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57496 ,  G01N2333/47 ,  G01N2333/908 ,  G01N2800/00

    摘要： [PROBLEM] To provide a monoclonal antibody against a biomarker which shows high specificity and can be effectively used in detection and diagnosis of various lesions relevant to various kinds of carcinomas and foci of necrosis, and so forth.[MEANS] A monoclonal antibody against a necrosis marker consisting the following amino acid sequence: (1) the amino acid sequence of SEQ ID NO: 1, or (2) an amino acid sequence having substitution, deletion and/or insertion of one or several amino acid residues in the amino acid sequence of (1) or sharing a homology of 90% or more with the amino acid sequence of (1), and showing the same function, activity or property as that of the amino acid sequence of (1) as a protein.

    摘要翻译： 提供针对生物标志物的单克隆抗体，其显示高特异性并且可以有效地用于检测和诊断与各种癌症和坏死灶相关的各种损伤等。 一种针对包含以下氨基酸序列的坏死标记的单克隆抗体：（1）SEQ ID NO：1的氨基酸序列，或（2）具有取代，缺失和/或插入的氨基酸序列之一或 （1）的氨基酸序列中的几个氨基酸残基或与（1）的氨基酸序列具有90％以上的同源性，并且与（1）的氨基酸序列具有相同的功能，活性或性质 1）作为蛋白质。

    MONOCLONAL ANTIBODY AGAINST NECROSIS MARKER ERP29 AND USE THEREOF
    4.
    发明申请
    MONOCLONAL ANTIBODY AGAINST NECROSIS MARKER ERP29 AND USE THEREOF 有权
    单克隆抗体对NECROSIS MARKER ERP29及其用途

    公开(公告)号：US20130040311A1

    公开(公告)日：2013-02-14

    申请号：US13583312

    申请日：2011-03-08

    申请人： Sumio Sugano ,  Yukari Kanzaki ,  Tsuneo Saga ,  Atsushi Tsuji

    发明人： Sumio Sugano ,  Yukari Kanzaki ,  Tsuneo Saga ,  Atsushi Tsuji

    IPC分类号： G01N33/566 ,  C07K16/18 ,  G01N33/573

    CPC分类号： G01N33/574 ,  A61K51/1045 ,  A61K51/1093 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/14 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57496 ,  G01N2333/47 ,  G01N2333/908 ,  G01N2800/00

    摘要： [PROBLEM] To provide a monoclonal antibody against a biomarker which shows high specificity and can be effectively used in detection and diagnosis of various lesions relevant to various kinds of carcinomas and foci of necrosis, and so forth.[MEANS] A monoclonal antibody against a necrosis marker consisting the following amino acid sequence: (1) the amino acid sequence of any of SEQ ID NOs: 1 to 3, or (2) an amino acid sequence having substitution, deletion and/or insertion of one or several amino acid residues in the amino acid sequence of (1) or sharing a homology of 90% or more with the amino acid sequence of (1), and showing the same function, activity or property as that of the amino acid sequence of (1) as a protein.

    摘要翻译： 提供针对生物标志物的单克隆抗体，其显示高特异性并且可以有效地用于检测和诊断与各种癌症和坏死灶相关的各种损伤等。 构成下列氨基酸序列的抗坏血酸标记单克隆抗体：（1）SEQ ID NO：1〜3中任一项所述的氨基酸序列，或（2）具有取代，缺失和/或缺失的氨基酸序列 在（1）的氨基酸序列中插入一个或几个氨基酸残基或与（1）的氨基酸序列共享90％以上的同源性，并显示与氨基酸的氨基酸序列相同的功能，活性或性质 （1）的酸序列作为蛋白质。

    Monoclonal antibody against necrosis marker ERP29 and use thereof
    8.
    发明授权
    Monoclonal antibody against necrosis marker ERP29 and use thereof 有权
    针对坏死标记物ERP29的单克隆抗体及其用途

    公开(公告)号：US09377461B2

    公开(公告)日：2016-06-28

    申请号：US13583312

    申请日：2011-03-08

    申请人： Sumio Sugano ,  Yukari Kanzaki ,  Tsuneo Saga ,  Atsushi Tsuji

    发明人： Sumio Sugano ,  Yukari Kanzaki ,  Tsuneo Saga ,  Atsushi Tsuji

    IPC分类号： C07K16/00 ,  C12P21/08 ,  G01N33/574 ,  A61K51/10 ,  C07K16/30 ,  C07K16/18

    CPC分类号： G01N33/574 ,  A61K51/1045 ,  A61K51/1093 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/14 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57496 ,  G01N2333/47 ,  G01N2333/908 ,  G01N2800/00

    摘要： [PROBLEM] To provide a monoclonal antibody against a biomarker which shows high specificity and can be effectively used in detection and diagnosis of various lesions relevant to various kinds of carcinomas and foci of necrosis, and so forth.[MEANS] A monoclonal antibody against a necrosis marker consisting the following amino acid sequence: (1) the amino acid sequence of any of SEQ ID NOs: 1 to 3, or (2) an amino acid sequence having substitution, deletion and/or insertion of one or several amino acid residues in the amino acid sequence of (1) or sharing a homology of 90% or more with the amino acid sequence of (1), and showing the same function, activity or property as that of the amino acid sequence of (1) as a protein.

    摘要翻译： 提供针对生物标志物的单克隆抗体，其显示高特异性并且可以有效地用于检测和诊断与各种癌症和坏死灶相关的各种损伤等。 构成下列氨基酸序列的抗坏血酸标记单克隆抗体：（1）SEQ ID NO：1〜3中任一项所述的氨基酸序列，或（2）具有取代，缺失和/或缺失的氨基酸序列 在（1）的氨基酸序列中插入一个或几个氨基酸残基或与（1）的氨基酸序列共享90％以上的同源性，并显示与氨基酸的氨基酸序列相同的功能，活性或性质 （1）的酸序列作为蛋白质。

    Monoclonal antibody against necrosis marker PRDX4 and use thereof
    9.
    发明授权
    Monoclonal antibody against necrosis marker PRDX4 and use thereof 有权
    针对坏死标记PRDX4的单克隆抗体及其用途

    公开(公告)号：US09164096B2

    公开(公告)日：2015-10-20

    申请号：US13583524

    申请日：2011-03-08

    申请人： Sumio Sugano ,  Yukari Kanzaki ,  Tsuneo Saga ,  Atsushi Tsuji

    发明人： Sumio Sugano ,  Yukari Kanzaki ,  Tsuneo Saga ,  Atsushi Tsuji

    IPC分类号： G01N33/53 ,  G01N33/574 ,  A61K51/10 ,  C07K16/30 ,  C07K16/18 ,  C07K16/00

    CPC分类号： G01N33/574 ,  A61K51/1045 ,  A61K51/1093 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/14 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57496 ,  G01N2333/47 ,  G01N2333/908 ,  G01N2800/00

    摘要： [PROBLEM] To provide a monoclonal antibody against a biomarker which shows high specificity and can be effectively used in detection and diagnosis of various lesions relevant to various kinds of carcinomas and foci of necrosis, and so forth.[MEANS] A monoclonal antibody against a necrosis marker consisting the following amino acid sequence: (1) the amino acid sequence of SEQ ID NO: 1, or (2) an amino acid sequence having substitution, deletion and/or insertion of one or several amino acid residues in the amino acid sequence of (1) or sharing a homology of 90% or more with the amino acid sequence of (1), and showing the same function, activity or property as that of the amino acid sequence of (1) as a protein.

    摘要翻译： 提供针对生物标志物的单克隆抗体，其显示高特异性并且可以有效地用于检测和诊断与各种癌症和坏死灶相关的各种损伤等。 一种针对包含以下氨基酸序列的坏死标记的单克隆抗体：（1）SEQ ID NO：1的氨基酸序列，或（2）具有取代，缺失和/或插入的氨基酸序列之一或 （1）的氨基酸序列中的几个氨基酸残基或与（1）的氨基酸序列具有90％以上的同源性，并且与（1）的氨基酸序列具有相同的功能，活性或性质 1）作为蛋白质。

    Methods for Obtaining Gene Tags
    10.
    发明申请
    Methods for Obtaining Gene Tags 审中-公开
    获取基因标签的方法

    公开(公告)号：US20090117538A1

    公开(公告)日：2009-05-07

    申请号：US10581211

    申请日：2004-06-04

    申请人： Shin-ichi Hashimoto ,  Kouji Matsushima ,  Sumio Sugano

    发明人： Shin-ichi Hashimoto ,  Kouji Matsushima ,  Sumio Sugano

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N15/79 ,  C12N5/10 ,  C12P21/02 ,  C12P19/34 ,  C07K14/00 ,  C07K16/00

    CPC分类号： C12Q1/6855 ,  C12N15/1096

    摘要： The present invention provides methods for providing as tags the nucleotide sequences at the 5′ end of mRNA. The method of the present invention comprises the step of synthesizing cDNA using, as a template, mRNA whose CAP structure is linked with a IIs linker having a type IIs endonuclease recognition sequence. Tags including the nucleotide sequence from the 5′ end of mRNA are generated by reacting the type IIs endonuclease to cDNA. Tags can be generated from all mRNA, independently of their nucleotide sequences. Methods for identifying transcriptional start sites and primers for full-length cDNA synthesis are provided based on the nucleotide sequence information of tags of the present invention.

    摘要翻译： 本发明提供了在mRNA的5'末端提供核苷酸序列作为标签的方法。 本发明的方法包括使用CAP结构与具有II型内切核酸酶识别序列的IIs连接子连接的mRNA作为模板来合成cDNA的步骤。 通过将II型核酸内切酶与cDNA反应产生包括mRNA的5'末端的核苷酸序列的标签。 标签可以从所有mRNA生成，与其核苷酸序列无关。 基于本发明的标签的核苷酸序列信息提供用于鉴定全长cDNA合成的转录起始位点和引物的方法。